5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

Product Name: 5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
CAS No.: 383392-66-3
Chemical Name: 5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
Synonyms: UC-112;CS-2116;UC 112,UC112;5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol;5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol;5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol;8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-
CBNumber: CB83038521
Molecular Formula: C22H24N2O2
Formula Weight: 348.44
MOL File: 383392-66-3.mol

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5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Property

Boiling point:: 515.5±45.0 °C(Predicted)
Density: 1.228±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 9.78±0.20(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5251
Product name: UC112
Purity: ≥98%(HPLC)
Packaging: 10
Price: $205
Updated: 2021/12/16

Tocris

Product number: 5251
Product name: UC112
Purity: ≥98%(HPLC)
Packaging: 50
Price: $865
Updated: 2021/12/16

Usbiological

Product number: 257010
Product name: UC 112
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: U130610
Product name: UC112
Packaging: 50mg
Price: $820
Updated: 2021/12/16

TRC

Product number: U130610
Product name: UC112
Packaging: 10mg
Price: $195
Updated: 2021/12/16

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5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Chemical Properties,Usage,Production

Uses

UC 112 is a novel second mitochondria-derived activator of caspase mimetics as selective inhibitors of apoptosis protein inhibitors.

Definition

ChEBI: 5-(phenylmethoxymethyl)-7-(1-pyrrolidinylmethyl)-8-quinolinol is a hydroxyquinoline.

Biological Activity

uc-112[5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol], is inhibitor of inhibitor of apoptosis protein (iap).[1]inhibitor of apoptosis protein (iap) family is overexpressed in most human cancer cells, but nearly isn’t expressed in adult differentiated tissues. inhibitor of apoptosis (iap) proteins are widely considered as promising drug-resistant tumors drug targets. [1,2]uc-112 strongly activates caspase-3/7 and caspase-9 activities, and selectively reduce surviving level at a concentration as low as 1 mm. coincubation of uc-112 with a known proteasome inhibitor z-leu-leu-leu-cho (mg-132) rescued survivin inhibition. as a single agent, uc-112 strongly inhibits tumor growth and reduces both x chromosomelinked iap and survivin levels in an a375 human melanoma xenograft model in vivo.[1]uc-112 inhibits tumor cell growth in several cancer cell lines in vitro and suppresses melanoma tumor growth in vivo. mechanistic studies indicated that uc-112 selectively inhibits survivin expression and induces strong cancer cell apoptosis. uc-112 could efficiently inhibit tumor cell proliferation by down regulating the level of iaps, especially survivin protein.[1,2]

storage

Store at +4°C

References

[1] wang j, li w. discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. j pharmacol exp ther. 2014 may;349(2):319-29.
[2] xiao m, wang j, lin z, etal. , design, synthesis and structure-activity relationship studies of novel survivin inhibitors with potent anti-proliferative properties. plos one. 2015 jun 12;10(6):e0129807.

5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Suppliers

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383392-66-3, 5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinolRelated Search:

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5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

UC-112

5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol

CS-2116

8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-

UC 112,UC112

383392-66-3