UC2288
- Product Name
- UC2288
- CAS No.
- 1394011-91-6
- Chemical Name
- UC2288
- Synonyms
- UC2288;UC2288 ，E1190;UC 2288, trans;p21 Inhibitor, UC2288;UC2288, 10 mM in DMSO;UC2288, p21 inhibitor;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]-;rac-1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1R,4R)-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea , UC2288
- CBNumber
- CB74718667
- Molecular Formula
- C20H18ClF6N3O2
- Formula Weight
- 481.82
- MOL File
- 1394011-91-6.mol
UC2288 Property
- Boiling point:
- 491.9±45.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml
- form
- A solid
- pka
- 12.88±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 5.32813
- Product name
- p21 Inhibitor, UC2288
- Packaging
- 10 mg
- Price
- $263
- Updated
- 2025/07/31
- Product number
- A1462621
- Product name
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
- Purity
- 98%
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- A1462621
- Product name
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
- Purity
- 98%
- Packaging
- 250mg
- Price
- $97
- Updated
- 2021/12/16
- Product number
- A1462621
- Product name
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(trans-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)urea
- Purity
- 98%
- Packaging
- 1g
- Price
- $241
- Updated
- 2021/12/16
UC2288 Chemical Properties,Usage,Production
Uses
UC2288 is a potent and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 potently inhibits cancer cell growth by inducing apoptosis. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM[1].
Biological Activity
Cell permeable: yes
in vivo
UC2888 (oral gavage; 15 mg/kg; 3 times a week; 4 weeks) co-treatment with imetelstat significantly suppresses tumor growth and does not effect mice weight[2].UC2288 (intraperitoneal injection; 10 mg/kg; 4 times in 7 days) attenuates MPTP-induced behavioral impairment, prevents activation of MAPK pathway in the MPTP-treated mice brain. MPTP treatment raises TNF-α, IL-6 and IL-1β levels in MPTP treated mice brain, but UC2288 signicantly decreases MPTP-induced TNF-α, IL-6 levels, but IL-1β is not decreased in brain[3].
| Animal Model: | Eight-week old, athymic nude (NCr nu/nu) mice injected subcutaneously with HCT116 and ACHN cancer cells(2.5x106)[2] |
| Dosage: | 15 mg/kg |
| Administration: | Oral gavage; 3 times a week; 4 weeks; co-treatment with imetelstat |
| Result: | Combined treatment with imetelstat synergistically inhibited tumor growth in mice. |
| Animal Model: | MPTP-induced C57BL6 Parkinson’s disease mice model[3] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal?injection; 4 times in 7 days |
| Result: | Ameliorated MPTP induced PD progression through inhibition of neuroinammation. |
References
[1] Hiromi I Wettersten, et al. A Novel p21 Attenuator Which Is Structurally Related to Sorafenib. Cancer Biol Ther.?2013 Mar;14(3):278-85. DOI:10.4161/cbt.23374
[2] Romi Gupta, et al. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3062-71. DOI:10.1073/pnas.1411370111
[3] Jun Hyung Im, et al. p21 inhibitor UC2288 ameliorates MPTP induced Parkinson’s disease progression through inhibition of oxidative stress and neuroinammation. Translational Medicine.Neurobiology of Disease
UC2288 Preparation Products And Raw materials
Raw materials
Preparation Products
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