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UCT943

Product Name
UCT943
CAS No.
1450666-80-4
Chemical Name
UCT943
Synonyms
UCT943;UCT-943,UCT943;UCT943, 10 mM in DMSO;(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(piperazin-1-yl)methanone;Methanone, [4-[5-amino-6-[4-(trifluoromethyl)phenyl]-2-pyrazinyl]phenyl]-1-piperazinyl-
CBNumber
CB94668627
Molecular Formula
C22H20F3N5O
Formula Weight
427.42
MOL File
1450666-80-4.mol
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UCT943 Property

Boiling point:
568.7±50.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (584.90 mM; Need ultrasonic)
form 
Solid
pka
8.25±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0046056
Product name
UCT943
Purity
98.70%
Packaging
5mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0046056
Product name
UCT943
Purity
98.70%
Packaging
10mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0046056
Product name
UCT943
Purity
98.70%
Packaging
50mg
Price
$2950
Updated
2021/12/16
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UCT943 Chemical Properties,Usage,Production

Uses

UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC50 of 23 nM[1].

in vivo

UCT943 shows excellent in vivo efficacy in the Plasmodium berghei (10 mg/kg and 3 mg/kg; oral administration; daily; 4 days) and P. falciparum NSG (NOD-scid IL-2Rγnull) mouse models (0.01, 0.1, 0.3, 1.1 and 10 mg/kg; oral administration; once per day; 4 days). When dosed at 10 mg/kg per os (p.o.), UCT943 reduces parasitemia by >99.9% in the mouse P. bergheiinfection model and cures all mice, with >30 mean survival days (MSD). At 3 mg/kg p.o., no complete cure is achieved, and MSD is 10 days, albeit parasitemia is reduced by 99%. The resulting 90% effective dose (ED90) is 1.0 mg/kg p.o. in the P. bergheiinfection model. The ED90 is 0.25 mg/kg in the P. falciparum-infected NSG mouse model[1].

Animal Model:Mice with P. berghei and P. falciparum NOD-scid IL-2Rγnull (NSG) models[1]
Dosage:10 mg/kg and 3 mg/kg for P. berghei model; 0.01, 0.1, 0.3, 1.1 and 10 mg/kg for P. falciparum NOD-scid IL-2Rγnull (NSG) model
Administration:Oral administration; daily; 4 days for P. berghei model
Oral administration; once per day; 4 days for P. falciparum NOD-scid IL-2Rγnull (NSG) model
Result:The ED90 is 1.0 mg/kg in the P. berghei infection model. The ED90 is 0.25 mg/kg in the P. falciparum-infected NSG mouse model.

IC 50

PvPI4K: 23 nM (IC50); Plasmodium

References

[1] Brunschwig C, et al. UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. DOI:10.1128/AAC.00012-18

UCT943 Preparation Products And Raw materials

Raw materials

Preparation Products

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UCT943 Suppliers

China 18 United States 2 Global 20
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2391
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
2993
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58

1450666-80-4, UCT943Related Search:

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  • UCT943
  • Methanone, [4-[5-amino-6-[4-(trifluoromethyl)phenyl]-2-pyrazinyl]phenyl]-1-piperazinyl-
  • UCT-943,UCT943
  • UCT943, 10 mM in DMSO
  • (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)phenyl)(piperazin-1-yl)methanone
  • 1450666-80-4