Isazophos Property

Melting point:

<25℃

Boiling point:

bp0.001 100°; bp760 170°

Density 

1.22 g/cm3 (20℃)

vapor pressure 

7.45 x 10^-3 Pa (20 °C)

refractive index 

nD20 1.4867

storage temp. 

0-6°C

form 

liquid

Water Solubility 

168 mg l^-1 (20 °C)

pka

-1.47±0.10(Predicted)

BRN 

8145294

EPA Substance Registry System

Isazofos (42509-80-8)

Safety

Hazard Codes 

T+,N

Risk Statements 

24/25-26-43-48/20-50/53

Safety Statements 

28-36/37-38-45-59-61

RIDADR 

3018

WGK Germany 

3

RTECS 

TE7760000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29339900

Hazardous Substances Data

42509-80-8(Hazardous Substances Data)

Toxicity

LD50 in rats (mg/kg): 60 orally; 250-700 dermally (Dawes)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P314Get medical advice/attention if you feel unwell.

Isazophos Chemical Properties,Usage,Production

Description

Isazofos is a yellow liquid. Solubility in water is 168 mg/L (20 ?C). It is miscible with common organic solvents. Log Kow = 2.99. It is hydrolyzed in aqueous media: DT₅₀ values (20 ?C) at pH 5, 7, and 9 are 85, 48, and 19 d, respectively.

Uses

Isazophos is an organophosphate pesticide.

Uses

Nematocide; turf insecticide.

Uses

Isazofos is used as a nematicide and soil insecticide in bananas, citrus, cotton, beet, maize, rice, vegetables, sugar cane and turf.

Definition

ChEBI: Isazofos is an organic thiophosphate.

Metabolic pathway

Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1- isopropyl-3-triazolol. The oxon metabolite has apparently not been identified.

Metabolism

In mammals, administered isazofos is rapidly metabolized and excreted, primarily in the urine, without accumulation in the body. The degradation route of isazofos in soil is primarily the hydrolysis mediated by microorganisms to give 5-chloro-1-isopropyl-3-triazole. The half-life in soils is about 10 d.

Toxicity evaluation

Acute oral LD₅₀ for rats is 40–60 mg/kg. Inhalation LC50 (4 h) for rats is about 0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet (0.1 mg/kg/d).

Degradation

Isazofos is hydrolysed more rapidly in alkaline rather than acid solution. The DT₅₀ values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively (PM).