5-(4-Fluorophenyl)pyridine-2-carboxylic acid
- Product Name
- 5-(4-Fluorophenyl)pyridine-2-carboxylic acid
- CAS No.
- 845826-99-5
- Chemical Name
- 5-(4-Fluorophenyl)pyridine-2-carboxylic acid
- Synonyms
- 5-(4-Fluorophenyl)-picolinic acid;5-(3-Chlorophenyl)-picolinic acid;5-(2-Chlorophenyl)-picolinic acid;5-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID;5-(4-Fluorophenyl)-2-pyridinecarboxylic acid;5-(4-Fluorophenyl)-pyridin-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-(4-fluorophenyl)-;5-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID, 95+%
- CBNumber
- CB7476361
- Molecular Formula
- C12H8FNO2
- Formula Weight
- 217.2
- MOL File
- 845826-99-5.mol
5-(4-Fluorophenyl)pyridine-2-carboxylic acid Property
- Boiling point:
- 394.9±32.0 °C(Predicted)
- Density
- 1.318±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 0.92±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F621275
- Product name
- 5-(4-Fluorophenyl)picolinicacid
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 126297
- Product name
- 5-(4-Fluorophenyl)picolinicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $314
- Updated
- 2021/12/16
- Product number
- Z5173
- Product name
- 5-(4-Fluorophenyl)pyridine-2-carboxylicacid
- Packaging
- 5g
- Price
- $744
- Updated
- 2021/12/16
- Product number
- 126297
- Product name
- 5-(4-Fluorophenyl)picolinicacid
- Purity
- >95%
- Packaging
- 5g
- Price
- $987
- Updated
- 2021/12/16
- Product number
- COR0003175
- Product name
- 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1030.84
- Updated
- 2021/12/16
5-(4-Fluorophenyl)pyridine-2-carboxylic acid Chemical Properties,Usage,Production
Uses
5-(4-Fluorophenyl)picolinic acid
Synthesis
30766-11-1
1765-93-1
845826-99-5
Step A: 5-bromopyridine-2-carboxylic acid (57, 1.0 g, 5.0 mmol) was dissolved in a solvent mixture of ethylene glycol dimethyl ether (12 mL) and water (4 mL). Subsequently, 4-fluorophenylboronic acid (17, 1.0 g, 7.5 mmol), anhydrous potassium carbonate (1.0 g, 7.5 mmol) and tetrakis(triphenylphosphine)palladium (289 mg, 0.25 mmol) were added sequentially. The reaction mixture was stirred at 98 °C for 24 h under nitrogen protection. After the completion of the reaction was monitored by thin layer chromatography (TLC), the reaction solution was cooled to room temperature. Water (40 mL) was added to the reaction solution and the pH was adjusted to 2-3 with 6 M hydrochloric acid solution. the precipitate was collected by filtration, the filter cake was redissolved in dichloromethane, and the organic layer was separated and washed with water. The aqueous phase was again adjusted to pH 2-3 with 6 M hydrochloric acid solution and the solid product was collected by filtration. The filter cake was washed with water to neutral and dried to give the crude product. The crude product was treated with 20 mL of saturated sodium bicarbonate solution to give the final target compound 5-(4-fluorophenyl)pyridine-2-carboxylic acid (61,942 mg) in 87.7% yield.
References
[1] Patent: CN108623532, 2018, A. Location in patent: Paragraph 0206; 0207; 0208
[2] Patent: EP1657242, 2006, A1. Location in patent: Page/Page column 31
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 812 - 819
[4] Medicinal Chemistry, 2017, vol. 13, # 2, p. 176 - 185
[5] Medicinal Chemistry Research, 2018, vol. 27, # 2, p. 374 - 387
5-(4-Fluorophenyl)pyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
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