N-Acetyl carnosine

Product Name: N-Acetyl carnosine
CAS No.: 56353-15-2
Chemical Name: N-Acetyl carnosine
Synonyms: N-ACETYL-L-CARNOSINE;Acetyl Carnosine;N-Aceyl-L-Carnosine;Can-C;Acetyl carinine;Ac-βAla-L-His-OH;AC-SS-ALA-HIS-OH;N-Acetyl camosine;n-acetyl carnosine;Carnosine Impurity 4
CBNumber: CB7476624
Molecular Formula: C11H16N4O4
Formula Weight: 268.27
MOL File: 56353-15-2.mol

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N-Acetyl carnosine Property

Melting point:: 209-210°C
Boiling point:: 775.9±60.0 °C(Predicted)
Density: 1.343±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
pka: 3.08±0.10(Predicted)
color: White to Off-White
InChI: InChI=1/C11H16N4O4/c1-7(16)13-3-2-10(17)15-9(11(18)19)4-8-5-12-6-14-8/h5-6,9H,2-4H2,1H3,(H,12,14)(H,13,16)(H,15,17)(H,18,19)/t9-/s3
InChIKey: BKAYIFDRRZZKNF-DJEYLCQNNA-N
SMILES: [C@H](C(=O)O)(NC(=O)CCNC(=O)C)CC1N=CNC=1 |&1:0,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18817
Product name: N-acetyl-L-Carnosine
Purity: ≥95%
Packaging: 1g
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 18817
Product name: N-acetyl-L-Carnosine
Purity: ≥95%
Packaging: 5g
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 18817
Product name: N-acetyl-L-Carnosine
Purity: ≥95%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

Usbiological

Product number: A0202-40
Product name: N-Acetyl-L-carnosine
Packaging: 100mg
Price: $319
Updated: 2021/12/16

TRC

Product number: A172015
Product name: N-Acetyl-L-carnosine
Packaging: 10g
Price: $340
Updated: 2021/12/16

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N-Acetyl carnosine Chemical Properties,Usage,Production

Description

N-acetyl-L-Carnosine is a dipeptide and acetylated form of L-carnosine that has been found in heart and skeletal muscle and has antioxidant and anticataract activities. It reduces iron- and ascorbate-induced malondialdehyde (MDA) accumulation in liposomes when used at concentrations of 10 and 20 mM. Topical administration of N-acetyl-L-carnosine (1% v/v) reduces cortical opacities in a canine model of age-related cataracts.

Chemical Properties

White Crystalline Solid

Uses

N-acetyl-L-Carnosine is used in the treatment of cataracts and in the treatment of UV-induced immunosuppression

Definition

ChEBI: A dipeptide that is the N-acetyl derivative of carnosine.

Synthesis

3025-95-4

71-00-1

56353-15-2

In a 500 mL three-necked flask, 300 mL of anhydrous ethanol was added and 80 g (0.611 mol) of N-acetyl-β-alanine and 86.1 g (0.555 mol) of L-histidine were sequentially added followed by 98 g (0.582 mol) of N,N'-dimethylcarbodiimide (DMC). The reaction mixture was heated to 40°C and the reaction was kept stirring for 3 hours. Upon completion of the reaction, the reaction solution was cooled to 5°C, a solid was precipitated and the solid product was collected by filtration. The filter cake was washed with 150 mL of anhydrous ethanol and dried under vacuum to give 145 g of (S)-2-(3-acetamidopropionamide)-3-(1H-imidazol-4-yl)propanoic acid (IV) in 97.9% yield and >98.8% HPLC purity.

in vivo

Right eyes of the rabbits (male grey chinchilla rabbits aged 3-4 months weighing 2-3 k) are instilled with 80 μL of formulation A containing 1 % N-Acetylcarnosine. The N-Acetylcarnosine prodrug eye drops optimize the clinical effects for the treatment of ophthalmic disorders (such as prevention and reversal of cataracts in human and animal eyes)^[1].

IC 50

Human Endogenous Metabolite

References

[1] Patent: CN105461632, 2016, A. Location in patent: Paragraph 0046

N-Acetyl carnosine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Acetyl carnosine Suppliers

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View Lastest Price from N-Acetyl carnosine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Acetyl carnosine 56353-15-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98.0%
Supply Ability: 1kg/month
Release date: 2021-08-24

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-Acetyl carnosine 56353-15-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: N-Acetyl carnosine 56353-15-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-21

56353-15-2, N-Acetyl carnosineRelated Search:

Acetylsalicylic acid Acetylacetone Acetaminophen Acetyl chloride Acetylcholine Acetylspiramycin Acetyl coenzyme A sodium salt (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride N-Acetyl-D-galactosamine N-Acetylglycine N-Acetyl-L-glutamic acid L-Carnosine Acetyl-resveratrol N-Acetyl carnosine ACETAMINOPHENOL BP/USP

(S)-2-(3-ACETYLAMINO-PROPIONYLAMINO)-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID

n-acetyl carnosine

N-ACETYL-L-CARNOSINE

N-A-ACETYL-N-B-ALANYL-L-HISTIDINE

N-Aceyl-L-Carnosine

N-Acetyl camosine

NAC, N-a-Acetyl-N-b-alanyl-L-histidine

N-(N-acetyl-beta-alanyl)-L-histidine

Acetyl-beta-alanyl-histidine

AC-SS-ALA-HIS-OH

Ac-βAla-L-His-OH

Nα-(N-Acetyl-β-alanyl)-L-histidine

L-Histidine, N-acetyl-.beta.-alanyl-

Ac-Beta-Ala-His-OH(L-Carnosine)

NAC, N-α-Acetyl-N-β-alanyl-L-histidine

(S)-2-(3-AcetaMidopropanaMido)-3-(1H-iMidazol-4-yl)propanoic acid

NAC, N-a-Acetyl-N--alanyl-L-histidine

L-Histidine, N-acetyl-b-alanyl-

N-Acetyl-L-carnosine, >=98.5%

Acetyl Carnosine

N-Acetyl carnosine / Dipeptide

Can-C

Carnosine Impurity 4

L-Histidine, N-acetyl-β-alanyl-

Acetyl carinine

N-Acetyl carnosine USP/EP/BP

Carnosine Impurity 2

N-Acetyl-L-CarnosineQ: What is N-Acetyl-L-Carnosine Q: What is the CAS Number of N-Acetyl-L-Carnosine Q: What is the storage condition of N-Acetyl-L-Carnosine Q: What are the applications of N-Acetyl-L-Carnosine

(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid

N-AcetylCarnosine: (S)-2-(3-Acetamidopropanamido)-3-(1H-imidazol-4-yl)propanoicacid

56353-15-2

56353-23-0

Amino Acids & Derivatives

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

PROTECTED AMINO ACID & PEPTIDES