N-Acetyl carnosine
- Product Name
- N-Acetyl carnosine
- CAS No.
- 56353-15-2
- Chemical Name
- N-Acetyl carnosine
- Synonyms
- N-ACETYL-L-CARNOSINE;Acetyl Carnosine;N-Aceyl-L-Carnosine;Can-C;Acetyl carinine;Ac-βAla-L-His-OH;AC-SS-ALA-HIS-OH;N-Acetyl camosine;n-acetyl carnosine;Carnosine Impurity 4
- CBNumber
- CB7476624
- Molecular Formula
- C11H16N4O4
- Formula Weight
- 268.27
- MOL File
- 56353-15-2.mol
N-Acetyl carnosine Property
- Melting point:
- 209-210°C
- Boiling point:
- 775.9±60.0 °C(Predicted)
- Density
- 1.343±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 3.08±0.10(Predicted)
- color
- White to Off-White
- InChI
- InChI=1/C11H16N4O4/c1-7(16)13-3-2-10(17)15-9(11(18)19)4-8-5-12-6-14-8/h5-6,9H,2-4H2,1H3,(H,12,14)(H,13,16)(H,15,17)(H,18,19)/t9-/s3
- InChIKey
- BKAYIFDRRZZKNF-DJEYLCQNNA-N
- SMILES
- [C@H](C(=O)O)(NC(=O)CCNC(=O)C)CC1N=CNC=1 |&1:0,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18817
- Product name
- N-acetyl-L-Carnosine
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 18817
- Product name
- N-acetyl-L-Carnosine
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 18817
- Product name
- N-acetyl-L-Carnosine
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- A0202-40
- Product name
- N-Acetyl-L-carnosine
- Packaging
- 100mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- A172015
- Product name
- N-Acetyl-L-carnosine
- Packaging
- 10g
- Price
- $340
- Updated
- 2021/12/16
N-Acetyl carnosine Chemical Properties,Usage,Production
Description
N-acetyl-L-Carnosine is a dipeptide and acetylated form of L-carnosine that has been found in heart and skeletal muscle and has antioxidant and anticataract activities. It reduces iron- and ascorbate-induced malondialdehyde (MDA) accumulation in liposomes when used at concentrations of 10 and 20 mM. Topical administration of N-acetyl-L-carnosine (1% v/v) reduces cortical opacities in a canine model of age-related cataracts.
Chemical Properties
White Crystalline Solid
Uses
N-acetyl-L-Carnosine is used in the treatment of cataracts and in the treatment of UV-induced immunosuppression
Definition
ChEBI: A dipeptide that is the N-acetyl derivative of carnosine.
Synthesis
3025-95-4
71-00-1
56353-15-2
In a 500 mL three-necked flask, 300 mL of anhydrous ethanol was added and 80 g (0.611 mol) of N-acetyl-β-alanine and 86.1 g (0.555 mol) of L-histidine were sequentially added followed by 98 g (0.582 mol) of N,N'-dimethylcarbodiimide (DMC). The reaction mixture was heated to 40°C and the reaction was kept stirring for 3 hours. Upon completion of the reaction, the reaction solution was cooled to 5°C, a solid was precipitated and the solid product was collected by filtration. The filter cake was washed with 150 mL of anhydrous ethanol and dried under vacuum to give 145 g of (S)-2-(3-acetamidopropionamide)-3-(1H-imidazol-4-yl)propanoic acid (IV) in 97.9% yield and >98.8% HPLC purity.
in vivo
Right eyes of the rabbits (male grey chinchilla rabbits aged 3-4 months weighing 2-3 k) are instilled with 80 μL of formulation A containing 1 % N-Acetylcarnosine. The N-Acetylcarnosine prodrug eye drops optimize the clinical effects for the treatment of ophthalmic disorders (such as prevention and reversal of cataracts in human and animal eyes)[1].
IC 50
Human Endogenous Metabolite
References
[1] Patent: CN105461632, 2016, A. Location in patent: Paragraph 0046
N-Acetyl carnosine Preparation Products And Raw materials
Raw materials
Preparation Products
N-Acetyl carnosine Suppliers
- Tel
- --
- Fax
- --
- ask@hamari.co.jp
- Country
- Japan
- ProdList
- 112
- Advantage
- 69
View Lastest Price from N-Acetyl carnosine manufacturers
- Product
- N-Acetyl carnosine 56353-15-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.0%
- Supply Ability
- 1kg/month
- Release date
- 2021-08-24
- Product
- N-Acetyl carnosine 56353-15-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- N-Acetyl carnosine 56353-15-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-21