ChemicalBook > CAS DataBase List > 4-(PYRIDIN-4-YL)ANILINE

4-(PYRIDIN-4-YL)ANILINE

Product Name
4-(PYRIDIN-4-YL)ANILINE
CAS No.
13296-04-3
Chemical Name
4-(PYRIDIN-4-YL)ANILINE
Synonyms
4-(Pyridin-4-yl);4-(4-Pyridyl)aniline;4-(4-Pyridinyl)aniline;4-(PYRIDIN-4-YL)ANILINE;4-(p-Aminophenyl)pyridine;4-(4-Aminophenyl)pyridine;4-PYRIDIN-4-YL-PHENYLAMINE;4-(4-Pyridinyl)benzenamine;4-(4-pyridinyl)benzeneaMine;4-(pyridin-4-yl)benzenaMine
CBNumber
CB7478471
Molecular Formula
C11H10N2
Formula Weight
170.21
MOL File
13296-04-3.mol
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4-(PYRIDIN-4-YL)ANILINE Property

Melting point:
232-234℃
Boiling point:
319.1±17.0 °C(Predicted)
Density 
1.133
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
6.55±0.10(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C11H10N2/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-8H,12H2
InChIKey
GKVYVZSNXXTOMQ-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(C2C=CN=CC=2)C=C1
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38-38
Safety Statements 
26-36/37/39
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2782
Product name
4-(Pyridin-4-yl)aniline
Packaging
1G
Price
$160
Updated
2025/07/31
TCI Chemical
Product number
P2782
Product name
4-(Pyridin-4-yl)aniline
Packaging
5G
Price
$568
Updated
2025/07/31
TRC
Product number
P840665
Product name
4-(4-Pyridinyl)aniline
Packaging
2.5g
Price
$475
Updated
2021/12/16
Matrix Scientific
Product number
074012
Product name
4-(Pyridin-4-yl)aniline
Purity
95+%
Packaging
1g
Price
$520
Updated
2021/12/16
Apolloscientific
Product number
OR912614
Product name
4-(Pyridin-4-yl)aniline
Purity
95%
Packaging
250mg
Price
$232
Updated
2021/12/16
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4-(PYRIDIN-4-YL)ANILINE Chemical Properties,Usage,Production

Uses

4-(4-Pyridinyl)aniline is diazotized, its product is nitrated and reduced to form 2-Amino-4-(4-pyridyl)phenol, which can increase cardiac contractility; Also, it is derived from 4-Pyridineboronic Acid (P991355), which is boronic acid derivative and their binding affinities with diols.

Synthesis

197435-52-2

13296-04-3

Tert-butyl 4-(pyridin-4-yl)phenylcarbamate (600 mg, 2.2 mmol) was treated with a mixture of dichloromethane (DCM) and trifluoroacetic acid (TFA) (1:1, 1 mL) for 2 hr at room temperature, and upon completion of the reaction, 4-(pyridin-4-yl)aniline (20) (380 mg, 99%) was obtained. Subsequently, the solvent was removed by distillation under reduced pressure. The structure of the product 4-(pyridin-4-yl)aniline (20) was 1H NMR (400 MHz, d6-DMSO) δ 8.81 (s, 2H), 8.25 (s, 2H), 7.76 (d, J = 8.7 Hz, 2H), 6.87 (m, 2H), 2.09 (s, 2H) and mass spectrometry (ESI) m/z 171 [M + H]+ for Confirmation. High resolution mass spectrometry (HRMS) calculated value of CnHn2 171.0917 and measured value of 171.0938 further verified the structure of the product.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 2474 - 2478
[2] Patent: WO2013/112722, 2013, A1. Location in patent: Page/Page column 45
[3] Dyes and Pigments, 2017, vol. 137, p. 229 - 235
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 22, p. 3542 - 3550

4-(PYRIDIN-4-YL)ANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(PYRIDIN-4-YL)ANILINE Suppliers

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View Lastest Price from 4-(PYRIDIN-4-YL)ANILINE manufacturers

Career Henan Chemical Co
Product
4-(PYRIDIN-4-YL)ANILINE 13296-04-3
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

13296-04-3, 4-(PYRIDIN-4-YL)ANILINERelated Search:


  • 4-PYRIDIN-4-YL-PHENYLAMINE
  • 4-(PYRIDIN-4-YL)ANILINE
  • 4-(4-Aminophenyl)pyridine
  • 4-(pyridin-4-yl)benzenaMine
  • 4-(4-Pyridinyl)benzenamine
  • 4-(4-Pyridyl)aniline
  • 4-(p-Aminophenyl)pyridine
  • 4-(4-pyridinyl)benzeneaMine
  • Pyridine, 4-(p-aminophenyl)-
  • 4-(Pyridin-4-yl)
  • Benzenamine, 4-(4-pyridinyl)-
  • 4-(4-Pyridinyl)aniline
  • 13296-04-3
  • pharmacetical