Cefdinir

Brand Name(s) in US

Product Name: Cefdinir
CAS No.: 91832-40-5
Chemical Name: Cefdinir
Synonyms: Omnicef;Cefzon;CFDN;Omnice;FK-482;CI 983;Novacef;cefdinyl;bmy28488;CEFDINIR
CBNumber: CB7483101
Molecular Formula: C14H13N5O5S2
Formula Weight: 395.41
MOL File: 91832-40-5.mol

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Cefdinir Property

Melting point:: >180°C dec.
Density: 1.89±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: dilute HCl: slightly soluble
pka: 9.70(at 25℃)
form: solid
color: Pale Yellow to Light Yellow
Water Solubility: Soluble in water
λmax: 295nm(DMSO)(lit.)
Merck: 14,1920
BCS Class: 4
InChI: InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
InChIKey: RTXOFQZKPXMALH-GHXIOONMSA-N
SMILES: N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\O)=O)C1=O)SCC(C=C)=C2C(O)=O
CAS DataBase Reference: 91832-40-5(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: XI0367250
HS Code: 2941906000
Toxicity: LD50 orl-rat: >5600 mg/kg IYKEDH 23,93,1992

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7118
Product name: Cefdinir
Purity: ≥95% (HPLC)
Packaging: 1g
Price: $160
Updated: 2023/06/20

TCI Chemical

Product number: C3111
Product name: Cefdinir
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $105
Updated: 2024/03/01

TCI Chemical

Product number: C3111
Product name: Cefdinir
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $263
Updated: 2024/03/01

Alfa Aesar

Product number: J66447
Product name: Cefdinir, 95%
Packaging: 1g
Price: $136
Updated: 2024/03/01

Alfa Aesar

Product number: J66447
Product name: Cefdinir, 95%
Packaging: 5g
Price: $415.65
Updated: 2024/03/01

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Cefdinir Chemical Properties,Usage,Production

Brand Name(s) in US

Omnicef

Description

Cefdinir is a cephalosporin antibiotic. It is active against numerous Gram-positive and Gram-negative bacteria, including β-lactamase-producing E. coli, K. oxytoca, K. pneumoniae, and P. aeruginosa clinical isolates (MICs = 0.25-16 μg/ml). Cefdinir is protective against sepsis induced by strains of S. aureus or H. influenzae in mice with 50% protective dose (PD₅₀) values of 2.7-35 and 3.1-5.8 mg/kg, respectively. Formulations containing cefdinir have been used in the treatment of Gram-positive and Gram-negative infections.

Description

Cefdinir is an orally active, beta-lactamase stable cephalosporin with a broad spectrum of activity. Compared to other oral cephalosporins, cefdinir is more potent against Gram-positive bacteria, especially Staphylococci. Its activity against Gram-negative bacteria such as E.coli,K. pneumoniae and P.mirabilis is similar to cefixime, but superior to cefaclor and cephalexin.

Chemical Properties

Pale Yellow Solid

Originator

Fujisawa (Japan)

Uses

A Cephalosporin antibiotic structurally similar to Cefixime

Uses

antihypertensive, ACE inhibitor

Uses

A broad spectrum antibiotic targeting both Gram-positive and Gram-negative pathogens

Definition

ChEBI: A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.

Manufacturing Process

By interaction of 7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene- 2-carboxylic acid 4-methoxyphenyl ester with 4-bromoacetyl bromide was prepared 7-(4-bromo-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0)oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. The active methylene group in that product was then nitrosated with sodium nitrite. The initial product spontaneously tautomerizes to afford 7-(4-bromo-2- hydroxyimino-3-oxo-butyrylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0) oct-2-ene-2-carboxylic acid 4-methoxyphenyl ester. By the reaction of that compound with thiourea and then with trifluoroacetic acid was obtained (6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-8-oxo-3-vinyl-5-thia-1- azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium nitrite, (Z)-oxime (Cefdinir sodium nitrile).
In practice it is usually used as free acid.
Synthesis of 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trytiloxyimino)acetamido]-3- vinyl-3-cephem-4-carboxylic acid x p-toluenesulfonic acid x 2 N,N-dimethylacetamide (the precursor of Cefdinir) was described in Patent US 6,093,814.

brand name

Cefzon

Therapeutic Function

Antibiotic

Antimicrobial activity

An oral cephalosporin similar in structure to cefixime, but with a slightly modified side chain at the 7-amino position. Activity is similar to that of cefixime, but it is more active, especially against staphylococci. It is not hydrolyzed by staphylococcal or the common plasmid-mediated enterobacterial β-lactamases. An enhancing effect on phagocytosis has been demonstrated in vitro.
Oral absorption is about 35%. A 200 mg oral dose achieves a plasma concentration of 1 mg/L after c. 3 h. Absorption is reduced after a fatty meal. Concentrations equal to or higher than corresponding plasma levels were present in blister fluid 6–12 h after administration of an oral dose. The plasma halflife is 1.5 h. Protein binding is 60–70%. A total of 12–20% of the dose was excreted in the urine within 12 h, the renal elimination declining with increasing dose. The elimination half-life and peak plasma concentration are increased in renal failure. About 60% of the drug is removed by hemodialysis.
Side effects and uses are those common to oral cephalosporins.

Safety Profile

Moderately toxic by ingestion andintravenous routes. Low toxicity by intraperitoneal andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Cefdinir Preparation Products And Raw materials

Raw materials

Amine compound Acetyl bromide Anisole Trifluoroacetic acid (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Ethyl acetate N-(Trimethylsilyl)acetamide N,N-Dimethylacetamide Chloromethane

Preparation Products

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Cefdinir Suppliers

Americas 1 Bangladesh 1 Belgium 1 Brazil 1 Canada 7 China 308 Europe 4 France 2 Germany 7 India 77 Italy 1 Japan 2 Jordan 1 Nepal 1 Poland 2 Singapore 1 South Korea 6 Spain 1 Switzerland 2 United Kingdom 15 United States 41 Uruguay 1 Global 483

AA Mangenius Health Care

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CMS Chemicals Limited

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Apin Chemicals Limited (UK)

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Key Organics Limited/Bionet Research

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CARBONE SCIENTIFIC CO.,LTD

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View Lastest Price from Cefdinir manufacturers

HebeiShuoshengImportandExportco.,Ltd

Product: Cefdinir 91832-40-5
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-05

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cefdinir 91832-40-5
Price: US $0.00-0.00/Kg/Drum
Min. Order: 100g
Purity: 99%min
Supply Ability: 100kg
Release date: 2021-10-26

Hebei Longbang Technology Co., Ltd

Product: Cefdinir 91832-40-5
Price: US $6.00/kg
Min. Order: 1kg
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-05-24

91832-40-5, CefdinirRelated Search:

Glycine 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE N-Vinyl-2-pyrrolidone VINYL PROPIONATE ALTRENOGEST Triethoxyvinylsilane CHLOROPHOSPHONAZO III Betaine Silicone rubber,methyl-vinyl Vinyl ester resin Vinyl resin Cefixime Ceftiolene Cefditoren Cefditoren pivoxil (Z)-2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)-2-METHOXYIMINO ACETIC ACID (Benzothiazol-2-yl)-(Z)-2-trityloxyimino-2-(2-aminothiazole-4-yl)-thioacetate YTTERBIUM(III) IONOPHORE I

(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-hydroxyimino-1-oxoethyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6r-(6-alpha,7-beta(z)))-)(hydroxyiminoacetyl)amino)-3-ethenyl-8-oxo

bmy28488

cefdinyl

8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

7-[2-(2-AMINOTHIAZOL-4-YL)-2-HYDROXYIMINOACETYLAMINO]-8-OXO-3-VINYL-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2

(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo--5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

FK-482

Omnice

CEFDIRNIR

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-, [6R-[6a,7b(Z)]]-

CEFDINIR

PD 134393

[6R-[6α-7beta(Z)]]-7-[[(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

syn-7-[2-(2-amino-4-thiazolyl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylic acid

Cefdinir, >=97%

Cefdinir API

Omnicef

Novacef

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)-

Cefzon

CFDN

CI 983

BMY-28488, FK-482, syn-7-[2-(2-amino-4-thiazolyl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylic acid, [6R-[6α-7beta(Z)]]-7-[[(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

[6R-[6α，7β(Z)]]_7-[[(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyimino-acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(hydroxyimino acetyl)amino)-3-ethenyl-8-oxo-, (6R-(6-alpha,7-beta(Z)))-

(6R,7R)-3-Vinyl-7-[(2-amino-4-thiazolyl)[(Z)-hydroxyimino]acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid

(6R,7R)-7α-[[(2-Amino-4-thiazolyl)[(Z)-hydroxyimino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefdinir (200 mg)

Cefdinir (300 mg)

(6R,7R)-7-[(2Z)-2-(2-aMino-1,3-thiazol-4-yl)-2-(N-hydroxyiMino)acetaMido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefdinir &gt

Cefdinir Cefdinir

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)-

(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefdinir USP/EP/BP

Cefdinir (Unlabelled)

Cefdinir (FK-482

Cefdinir 15N2,13CQ: What is Cefdinir 15N2,13C Q: What is the CAS Number of Cefdinir 15N2,13C Q: What is the storage condition of Cefdinir 15N2,13C Q: What are the applications of Cefdinir 15N2,13C

CefdinirQ: What is Cefdinir Q: What is the CAS Number of Cefdinir Q: What is the storage condition of Cefdinir Q: What are the applications of Cefdinir

TIANFUCHEM--91832-40-5--High purity Cefdinir factory price

Cefdinir (1097614)

To cephalosporin,

cefdinil

Cefdinib

Cefodinir

91832-40-5

1832-40-5

C14H13N5O5S2

cephalosporins

Chiral Reagents

ACEON

Miscellaneous Biochemicals

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds