CAERULOMYCIN A
- Product Name
- CAERULOMYCIN A
- CAS No.
- 21802-37-9
- Chemical Name
- CAERULOMYCIN A
- Synonyms
- CERULOMYCIN;CAERULOMYCIN;AERULOMYCIN A;Carulomycin A;CAERULOMYCIN A;Caerulomycin, Cerulomycin;CeruloMycin, CaeruloMycin A;Fungal,Antibiotic,Caerulomycin A,inhibit,Inhibitor;4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime;(E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime
- CBNumber
- CB7484496
- Molecular Formula
- C12H11N3O2
- Formula Weight
- 229.23
- MOL File
- 21802-37-9.mol
CAERULOMYCIN A Property
- Melting point:
- 173 °C
- Boiling point:
- 420.0±45.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml).
- form
- solid
- pka
- 9.89±0.50(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C6374
- Product name
- Caerulomycin A
- Purity
- from
- Packaging
- 1mg
- Price
- $449
- Updated
- 2024/03/01
- Product number
- 27625
- Product name
- Caerulomycin A
- Packaging
- 1mg
- Price
- $340
- Updated
- 2024/03/01
- Product number
- 27625
- Product name
- Caerulomycin A
- Packaging
- 5mg
- Price
- $1186
- Updated
- 2024/03/01
- Product number
- C700030
- Product name
- Caerulomycin A
- Packaging
- 1mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- orb546133
- Product name
- Caerulomycin A
- Purity
- >98%
- Packaging
- 100μg
- Price
- $209.1
- Updated
- 2021/12/16
CAERULOMYCIN A Chemical Properties,Usage,Production
Description
Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion?in vitro?and?in vivo.1 Caerulomycin A induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling.2
Uses
Caerulomycin is a rare and unusual antibiotic containing a core 2, 2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces caeruleus isolated in Canada in 1959. Caerulomycin is active against fungi and some protozoans, and is weakly active against bacteria. While its discovery has stimulated some synthetic effort, little is known about the mode and spectrum of action of caerulomycin.
Uses
Caerulomycin A is a pyridine derived antiobiotic with a broad spectrum of bioactivity.
Definition
ChEBI: Caerulomycin A is a pyridine alkaloid that is 2,2'-bipyridine substituted by a methoxy group at position 4 and a (E)-(hydroxyimino)methyl group at position 6. Isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus, it exhibits antineoplastic activity. It has a role as an antineoplastic agent, a marine metabolite and a bacterial metabolite. It is an aldoxime, an aromatic ether, a member of bipyridines and a pyridine alkaloid. It derives from a hydride of a 2,2'-bipyridine.
References
1) Singla?et al. (2014),?Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One,?9(10)?e107051 2) Gurram?et al. (2014),?Caerulomycin A enhances transforming growth factor-beta (TGF-β)-Smad3 protein signaling by suppressing interferon-gamma (IFN-γ)-signaling to expand regulatory T cells (Tregs); J. Biol. Chem.?289?17515
CAERULOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CAERULOMYCIN A manufacturers
- Product
- AERULOMYCIN A 21802-37-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25