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(+/-)-PROPIONYLCARNITINE CHLORIDE

Product Name
(+/-)-PROPIONYLCARNITINE CHLORIDE
CAS No.
17298-37-2
Chemical Name
(+/-)-PROPIONYLCARNITINE CHLORIDE
Synonyms
Hsdb 7589;Propionyl Carnitine;Propionyl DL carnitine;O-propanoyl-L-carnitine;(+/-)-Propionylcarnitinechloride;(+/-)-PROPIONYLCARNITINE CHLORIDE;3-propanoyloxy-4-trimethylammonio-butanoate;3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt;1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-, inner salt
CBNumber
CB7486526
Molecular Formula
C10H19NO4
Formula Weight
217.27
MOL File
17298-37-2.mol
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(+/-)-PROPIONYLCARNITINE CHLORIDE Property

storage temp. 
Desiccate at RT
solubility 
DMSO: 125 mg/mL (575.35 mM)
form 
Solid
color 
White to off-white
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Safety

Hazardous Substances Data
17298-37-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris
Product number
0611
Product name
(+/-)-Propionylcarnitinechloride
Purity
≥95%
Packaging
50
Price
$96
Updated
2021/12/16
Usbiological
Product number
P9052-05T
Product name
Propionyl Carnitine
Packaging
100mg
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BIO0000099
Product name
PROPIONYL CARNITINE
Purity
95.00%
Packaging
50MG
Price
$648.83
Updated
2021/12/16
ChemScene
Product number
CS-0059547
Product name
Propionylcarnitine
Packaging
10mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-0059547
Product name
Propionylcarnitine
Packaging
5mg
Price
$90
Updated
2021/12/16
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(+/-)-PROPIONYLCARNITINE CHLORIDE Chemical Properties,Usage,Production

Uses

Propionylcarnitine is metabolized by carnitine acetyltransferase from propionyl-CoA. Increased propionylcarnitine is regarded as a biomarker of vitamin B12 deficiency[1][2].

Definition

ChEBI: O-propanoylcarnitine is an O-acylcarnitine compound having propanoyl as the acyl substituent. It has a role as an analgesic, an antirheumatic drug, a cardiotonic drug, a peripheral nervous system drug and a human metabolite. It is functionally related to a propionic acid.

in vivo

Propionylcarnitine (2 mM/kg; p.o. for 4 weeks) affects plasma and urine total carnitine concentrations of mice[3].

Animal Model:Adult age-matched male C57BL/6 mice[5]
Dosage:2 mM/kg/day
Administration:Oral gavage; 2 mM/kg/day for 4 weeks
Result:Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice.

IC 50

Human Endogenous Metabolite

References

[1] Jacobs PL, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr. 2009;6:9. Published 2009 Apr 2. DOI:10.1186/1550-2783-6-9
[2] Kowal A, et al. Propionylcarnitine and methionine concentrations in newborns with hypospadias. Cent European J Urol. 2013;66(3):377-380. DOI:10.5173/ceju.2013.03.art36
[3] Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9. PMID:7852033
[4] Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. DOI:10.1006/bbrc.1994.1321
[5] Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25. DOI:10.1007/s00394-013-0631-6
[6] Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia. Int J Tissue React. 1991;13(1):37-40. PMID:1889961

(+/-)-PROPIONYLCARNITINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-PROPIONYLCARNITINE CHLORIDE Suppliers

Canada 1 China 28 Europe 1 Germany 2 United Kingdom 2 United States 4 Global 38
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
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7778
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Shanghai Macklin Biochemical Co.,Ltd.
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15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
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EMMX Biotechnology LLC
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888-539-0666
Fax
888-539-0666
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info@emmx.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
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9803
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Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-36031160 13311776681
Email
3338195766@QQ.com
Country
China
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5093
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Shanghai Biological Technology Development Co., Ltd.
Tel
021-69955236-807 13918189704
Fax
021-65211385
Email
chinaruji@chinaruji.com
Country
China
ProdList
5095
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Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
14948
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
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32435
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AFINE CHEMICALS LIMITED
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+86-0571-85134551
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008657185134895
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sales@afinechem.com
Country
China
ProdList
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17298-37-2, (+/-)-PROPIONYLCARNITINE CHLORIDERelated Search:

CAPRYLYL-L-CARNITINE CHLORIDE HEXANOYL-L-CARNITINE CHLORIDE Palmitoyl-L-Carnitine Chloride PALMITOYL-D-CARNITINE CHLORIDE (+/-)-OCTANOYLCARNITINE CHLORIDE BUTYRYL-L-CARNITINE CHLORIDE MYRISTOYL-L-CARNITINE CHLORIDE LINOLEOYL-L-CARNITINE CHLORIDE DECANOYL-L-CARNITINE CHLORIDE LAUROYL-L-CARNITINE CHLORIDE L-Propionylcarnitine chloride DL-LAUROYLCARNITINE CHLORIDE (+/-)-PROPIONYLCARNITINE CHLORIDE DL-DECANOYLCARNITINE CHLORIDE DL-STEAROYL CARNITINE CHLORIDE MYRISTOYL-DL-CARNITINE CHLORIDE OLEOYL-L-CARNITINE CHLORIDE DL-CAPROYLCARNITINE CHLORIDE

  • (+/-)-PROPIONYLCARNITINE CHLORIDE
  • Propionyl Carnitine
  • 3-propanoyloxy-4-trimethylammonio-butanoate
  • 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-, inner salt
  • 3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt
  • Hsdb 7589
  • (+/-)-Propionylcarnitinechloride
  • O-propanoyl-L-carnitine
  • Propionyl DL carnitine
  • 17298-37-2
  • Lipid signaling