ChemicalBook > CAS DataBase List > (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID

Product Name
(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID
CAS No.
7013-05-0
Chemical Name
(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID
Synonyms
(S)-4-AMINO-3-HYDROXYBUTANOIC ACID;S-(+)-GABOB;β-hydroxy-GABA;beta-hydroxy-GABA;(S)-(+)-3-Hydroxy-GABA;(S)-(+)-β-hydroxy-GABA;GABOB (beta-hydroxy-GABA);D-4-Amino-3-hydroxybutyric acid;(S)-4-AMINO-3-HYDROXYBUTYRIC ACID;(3S)-4-Amino-3-hydroxybutanoic acid
CBNumber
CB7488146
Molecular Formula
C4H9NO3
Formula Weight
119.12
MOL File
7013-05-0.mol
More
Less

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Property

Melting point:
207-212 °C
alpha 
20 º (C=1.7 IN H2O)
Boiling point:
374.5±32.0 °C(Predicted)
Density 
1.312±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Solid
pka
4.04±0.10(Predicted)
optical activity
[α]20/D +20.0°, c = 1.7 in H2O
InChI
InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1
InChIKey
YQGDEPYYFWUPGO-VKHMYHEASA-N
SMILES
C(O)(=O)C[C@H](O)CN
CAS DataBase Reference
7013-05-0(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
542946
Product name
(S)-(+)-4-Amino-3-hydroxybutyric acid
Purity
97%
Packaging
5g
Price
$588
Updated
2025/07/31
Sigma-Aldrich
Product number
542946
Product name
(S)-(+)-4-Amino-3-hydroxybutyric acid
Purity
97%
Packaging
1g
Price
$153
Updated
2023/06/20
Biosynth Carbosynth
Product number
FA165248
Product name
(S)-(+)-4-Amino-3-hydroxybutyric acid
Packaging
2g
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA165248
Product name
(S)-(+)-4-Amino-3-hydroxybutyric acid
Packaging
250mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA165248
Product name
(S)-(+)-4-Amino-3-hydroxybutyric acid
Packaging
500mg
Price
$100
Updated
2021/12/16
More
Less

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

S-(+)-GABOB anticonvulsant and is used in the treatment of epilepsy as it binds to the GABAB receptor.

General Description

(S)-(+)-4-Amino-3-hydroxybutyric acid [(S)-GABOB] can be prepared starting from ethyl (S)-4-chloro-3-hydroxybutyrate.

Synthesis

1431373-89-5

7013-05-0

GENERAL METHODS: Compound 7 (400 mg, 0.92 mmol) was dissolved in EtOAc (20 mL) and 10% Pd/C (785 mg, 0.74 mmol, 80 mol%) was added. The reaction system was degassed and hydrogenated under 1 atm H2 atmosphere for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford (S)-(+)-4-amino-3-hydroxybutyric acid ((S)-GABOB, 2) (95 mg, 87% yield) as a white solid. The product was purified by recrystallization from EtOH-H2O mixed solvent. Melting point: 200-202°C (literature value 13e: 198-201°C); [α]27D +17.2 (c 1.23, H2O) (literature value 13e: [α]25D +16.7 (c 0.41, H2O)).1H NMR (600 MHz, D2O): δ 2.44 (d, J = 6.6 Hz, 2H), 3.97 (dd J = 13.2, 9.6 Hz, 1H), 3.18 (dd, J = 13.2, 3.0 Hz, 1H), 4.19-4.23 (m, 1H). 13C NMR (150 MHz, D2O): δ 42.3, 44.1, 65.5, 178.6. HRMS (ESI): m/z [M + Na]+ calculated value C4H9NNaO3: 142.0480; measured value: 142.0462. ref 22: Abdel-Magid, A. F.; Carson, K.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 21, p. 2637 - 2640

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID Suppliers

China 66 France 1 Germany 2 India 1 Japan 1 Slovakia 1 Switzerland 1 United Kingdom 7 United States 18 Global 98
SINO High Goal Chemical Technology Co., Ltd.
Tel
021-57646680 18306277365
Email
guoxin@chembiobanksh.com
Country
China
ProdList
2666
Advantage
58
New Energy Chemicals
Tel
0515-82159099 13770142076
Fax
86-0515-8215909
Email
info@njuchem.com
Country
China
ProdList
242
Advantage
65
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Struchem Co., Ltd.
Tel
0512-63009836 18994340901
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3981
Advantage
60
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9287
Advantage
55
Zhengzhou AiXi Technology Co., Ltd.
Tel
0371-56787280 13137706083
Fax
-
Email
m18539565376@163.com
Country
China
ProdList
970
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
10410
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9721
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
1991
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11811
Advantage
58
Shanghai UCHEM Inc.
Tel
+862156762820 +86-13564624040
Email
sales@myuchem.com
Country
China
ProdList
8460
Advantage
58
Siyang Liaoning Biochemical Products Co. Ltd
Tel
+86-15221114306; +8615221114306
Fax
86-417-4890038
Email
2594582574@qq.com
Country
China
ProdList
561
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Nanjing shengyilai Chemical Co., Ltd
Tel
19951936396
Email
3158688292@qq.com
Country
China
ProdList
4856
Advantage
58
Zhende Chemical Technology (Shanghai) Co., Ltd.
Tel
15601952568
Fax
3004479441
Email
sales4@myuchem.com
Country
China
ProdList
2992
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai UCHEM Inc.
Tel
18939844854
Fax
QQ3004479448
Email
sales6@myuchem.com
Country
China
ProdList
4996
Advantage
58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd
Tel
15658004993
Email
1900830611@qq.com
Country
China
ProdList
980
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2815987 13927875076
Fax
0751-2828607
Email
3007432263@qq.com
Country
China
ProdList
9963
Advantage
58
NewCan Biotech Limited
Tel
+86-0571-86912261 +86-15658003402
Fax
311113
Email
sales@newcanbio.com
Country
China
ProdList
1391
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39665
Advantage
58
Chengdu Dorher Pharmaceutical CO.,Ltd
Tel
028-64259743; 19983537320
Email
bd-focus@focuspharm.com
Country
China
ProdList
682
Advantage
58
Zhengzhou Deyuankai Chemical Co., LTD
Tel
17837139533
Email
1165412154@qq.com
Country
China
ProdList
7740
Advantage
58
Qiyuan (Guangdong) Pharmaceutical Chemical Co., Ltd.
Tel
18026564465
Email
304903156@qq.com
Country
China
ProdList
8000
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50751
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
syeu@accelachem.com
Country
China
ProdList
11015
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
ZhengZhou Edward Biology Co.,Ltd
Tel
13298105281
Email
1522334715@qq.com
Country
China
ProdList
7507
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29257
Advantage
58
xinguokeji
Tel
13120711461
Email
363372932@qq.com
Country
China
ProdList
498
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Email
sales@coreychem.com
Country
China
ProdList
29846
Advantage
58
More
Less

View Lastest Price from (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID manufacturers

Shanghai UCHEM Inc.
Product
(S)-(+)-4-Amino-3-hydroxybutyric acid 7013-05-0
Price
US $209.00-954.00/g
Min. Order
5g
Purity
0.99
Supply Ability
1kg
Release date
2023-12-04
Career Henan Chemical Co
Product
(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID 7013-05-0
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-17

7013-05-0, (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACIDRelated Search:

ACETYL-PEPSTATIN D(+)-Carnitine L-Carnitine hydrochloride EST Pepstatin 4-Amino-2-hydroxybutanoic acid (R)-3-AMINO-4-HYDROXYBUTANOIC ACID HYDROCHLORIDE DL-4-Amino-3-hydroxybutyric acid allo-DL-Threonine L(+)-allo-Threonine (S)-N-Carbobenzyloxy-4-amino-2-hydroxybutyric acid DL-2-AMINO-3-HYDROXYBUTANOIC ACID 3-PHOSPHATE L-carnitine L-Threonine DL-2-AMINO-3-HYDROXYBUTANOIC ACID D(-)-allo-Threonine (3S,4S)-4-AMINO-3-HYDROXY-5-PHENYLPENTANOIC ACID FMOC-(3S,4S)-4-AMINO-3-HYDROXY-5-PHENYL PENTANOIC ACID

  • (S)-4-Amino-3-hydroxybutyric acid,99%
  • (S)-(+)-4-Amino-3-hydroxybutyric acid 97%
  • GABOB (beta-hydroxy-GABA)
  • [S,(+)]-3-Hydroxy-4-aminobutyric acid
  • D-4-Amino-3-hydroxybutyric acid
  • S-(+)-GABOB
  • (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID
  • (S)-4-AMINO-3-HYDROXYBUTANOIC ACID
  • (S)-4-AMINO-3-HYDROXYBUTYRIC ACID
  • (S)-(+)-AMINO-3-HYDROXYBUTANOIC ACID
  • (3S)-(+)-4-Amino-3-hydroxybutanoic acid
  • (3S)-4-Amino-3-hydroxybutanoic acid
  • (S)-(+)-3-Hydroxy-GABA
  • (S)-(+)-β-hydroxy-GABA
  • Butanoic acid, 4-amino-3-hydroxy-, (3S)-
  • S-(+)-γ-Amino-β-hydroxybutyric acid
  • BUTANOIC ACID, 4-AMINO-3-HYDROXY-, (S)
  • beta-hydroxy-GABA
  • β-hydroxy-GABA
  • (<i>S</i>)-(+)-4-Amino-3-hydroxybutyric acid
  • 7013-05-0
  • chiral
  • Carboxylic Acids
  • Chiral Building Blocks
  • Organic Building Blocks