METHACHOLINE BROMIDE
- Product Name
- METHACHOLINE BROMIDE
- CAS No.
- 333-31-3
- Chemical Name
- METHACHOLINE BROMIDE
- Synonyms
- Acetyl-βMethacholine;MECHOLYL BROMIDE;METHACHOLINE BROMIDE;METHYLCHOLINE BROMIDE;MethacholineBromide>(2-HYDROXYPROPYL)TRIMET;ACETYL-β-METHYLCHOLINEBROMID;ACETYL-B-METHYLCHOLINE BROMIDE;Acetyl-β-methylcholine bromide
- CBNumber
- CB7489800
- Molecular Formula
- C8H18BrNO2
- Formula Weight
- 240.14
- MOL File
- 333-31-3.mol
METHACHOLINE BROMIDE Property
- Melting point:
- 147-149 °C(lit.)
- Density
- 1.3952 (rough estimate)
- refractive index
- 1.6120 (estimate)
- storage temp.
- -20°C
- form
- Crystalline Powder
- color
- White to off-white
- Water Solubility
- almost transparency
- Sensitive
- Hygroscopic
- BRN
- 6098010
- EPA Substance Registry System
- 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (333-31-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2126
- Product name
- Acetyl-β-methylcholine bromide
- Purity
- ≥99%
- Packaging
- 100g
- Price
- $204.4
- Updated
- 2024/03/01
- Product number
- M0072
- Product name
- Methacholine Bromide
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $106
- Updated
- 2024/03/01
- Product number
- M0072
- Product name
- Methacholine Bromide
- Purity
- >99.0%(T)
- Packaging
- 100g
- Price
- $318
- Updated
- 2024/03/01
- Product number
- A186630
- Product name
- Acetyl-β-methylcholine bromide
- Packaging
- 10g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- API0001361
- Product name
- ACETYL-BETA-METHYL CHOLINE BROMIDE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1202.74
- Updated
- 2021/12/16
METHACHOLINE BROMIDE Chemical Properties,Usage,Production
Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
Methacholine is used only for bronchial hyperreactivity diagnostics. A synonym of this drug is provocholine.
Uses
Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.
General Description
Methacholine can exist as (S) and (R) enantiomers.Although the chemical is used as the racemic mixture, itsmuscarinic activity resides principally in the (S)-isomer.The (S)/(R) ratio of muscarinic potency for these enantiomersis 240:1.
Mechanism of action
A minor structural change is the presence of a methyl group at the β-carbon atom of choline, which results in two main changes in the pharmacological profile of the molecule. Unlike acetylcholine, methacholine is hydrolyzed only by acetylcholinesterase, and the rate of hydrolysis is significantly less than with acetylcholine. Thus, the action of methacholine is significantly longer lasting than acetylcholine. Moreover, the presence of a methyl group at the β-carbon of choline provides the compound with a greater selectivity of action. Methacholine directly acts on muscarinic receptors of smooth muscle, glands,and the heart, and it has a very weak effect on nicotinic receptors of the autonomic ganglions of skeletal muscle.
Synthesis
Methacholine, 1-acetoxy-2-(N,N,N-trimethyl)propyl ammonium chloride (13.1.4) or acetyl-β-methylcholine can be synthesized by any of the methods described above [8]
METHACHOLINE BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHACHOLINE BROMIDE manufacturers
- Product
- METHACHOLINE BROMIDE 333-31-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09