METHACHOLINE BROMIDE

ChemicalBook > CAS DataBase List > METHACHOLINE BROMIDE

METHACHOLINE BROMIDE

Product Name: METHACHOLINE BROMIDE
CAS No.: 333-31-3
Chemical Name: METHACHOLINE BROMIDE
Synonyms: Acetyl-βMethacholine;MECHOLYL BROMIDE;METHACHOLINE BROMIDE;METHYLCHOLINE BROMIDE;MethacholineBromide>(2-HYDROXYPROPYL)TRIMET;ACETYL-β-METHYLCHOLINEBROMID;ACETYL-B-METHYLCHOLINE BROMIDE;Acetyl-β-methylcholine bromide
CBNumber: CB7489800
Molecular Formula: C8H18BrNO2
Formula Weight: 240.14
MOL File: 333-31-3.mol

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METHACHOLINE BROMIDE Property

Melting point:: 147-149 °C(lit.)
Density: 1.3952 (rough estimate)
refractive index: 1.6120 (estimate)
storage temp.: -20°C
form: Crystalline Powder
color: White to off-white
Water Solubility: almost transparency
Sensitive: Hygroscopic
BRN: 6098010
EPA Substance Registry System: 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (333-31-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: Yes
HS Code: 29239000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A2126
Product name: Acetyl-β-methylcholine bromide
Purity: ≥99%
Packaging: 100g
Price: $204.4
Updated: 2024/03/01

TCI Chemical

Product number: M0072
Product name: Methacholine Bromide
Purity: >99.0%(T)
Packaging: 25g
Price: $106
Updated: 2024/03/01

TCI Chemical

Product number: M0072
Product name: Methacholine Bromide
Purity: >99.0%(T)
Packaging: 100g
Price: $318
Updated: 2024/03/01

TRC

Product number: A186630
Product name: Acetyl-β-methylcholine bromide
Packaging: 10g
Price: $305
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0001361
Product name: ACETYL-BETA-METHYL CHOLINE BROMIDE
Purity: 95.00%
Packaging: 25G
Price: $1202.74
Updated: 2021/12/16

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METHACHOLINE BROMIDE Chemical Properties,Usage,Production

Chemical Properties

WHITE CRYSTALLINE POWDER

Uses

Methacholine is used only for bronchial hyperreactivity diagnostics. A synonym of this drug is provocholine.

Uses

Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.

General Description

Methacholine can exist as (S) and (R) enantiomers.Although the chemical is used as the racemic mixture, itsmuscarinic activity resides principally in the (S)-isomer.The (S)/(R) ratio of muscarinic potency for these enantiomersis 240:1.

Mechanism of action

A minor structural change is the presence of a methyl group at the β-carbon atom of choline, which results in two main changes in the pharmacological profile of the molecule. Unlike acetylcholine, methacholine is hydrolyzed only by acetylcholinesterase, and the rate of hydrolysis is significantly less than with acetylcholine. Thus, the action of methacholine is significantly longer lasting than acetylcholine. Moreover, the presence of a methyl group at the β-carbon of choline provides the compound with a greater selectivity of action. Methacholine directly acts on muscarinic receptors of smooth muscle, glands,and the heart, and it has a very weak effect on nicotinic receptors of the autonomic ganglions of skeletal muscle.

Synthesis

Methacholine, 1-acetoxy-2-(N,N,N-trimethyl)propyl ammonium chloride (13.1.4) or acetyl-β-methylcholine can be synthesized by any of the methods described above [8]

METHACHOLINE BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHACHOLINE BROMIDE manufacturers

Career Henan Chemical Co

Product: METHACHOLINE BROMIDE 333-31-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

333-31-3, METHACHOLINE BROMIDERelated Search:

MEPENZOLATE BROMIDE (-)-BICUCULLINE METHOBROMIDE Glycopyrrolate METHACHOLINE BROMIDE Clidinium bromide dacuronium bromide BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Rocuronium bromide Pancuronium bromide Aclidinium bromide Vecuronium bromide benzilonium bromide CHOLINE CHOLINE BROMIDE (2-hydroxypropyl)trimethylammonium Rapacuronium METHACHOLINE BROMIDE(RG) METHACHOLINE BROMIDE(REAGENT / STANDARD GRADE)

1-Propanaminium,2-(acetyloxy)-N,N,N-trimethyl-,bromide

2-(acetyloxy)-n,n,n-trimethyl-1-propanaminiubromide

METHYLCHOLINE BROMIDE

MECHOLYL BROMIDE

METHACHOLINE BROMIDE

ACETYL-BETA-METHYLCHOLINE BROMIDE

ACETYL-B-METHYLCHOLINE BROMIDE

(2-HYDROXYPROPYL)TRIMETHYLAMMONIUM BROMIDE ACETATE

(2-ACETOXYPROPYL)TRIMETHYLAMMONIUM BROMIDE

O-ACETYL-BETA-METHYLCHOLINE BROMIDE

TRIMETHYL-B-ACETOXYPROPYLAMMONIUM BROMIDE

ACETYL-B-METHYLCHOLINE BROMIDECRYSTALLIN E

Acetyl-β-methylcholine bromide

Acetyl-&beta

Methacholine

acetyl á-methylcholine bromide

ACETYL SS-METHYLCHOLINE BROMIDE

ACETYL-β-METHYLCHOLINEBROMID

O-Acetyl-β-methylcholine bromide

rac-(R*)-O-Acetyl-β-methylcholine

Acetyl-beta-methylcholine bromide,99%

beta-Methylacetylcholine bromide

Trimethyl-beta-acetoxypropylammonium bromide

Acetyl choline Methyl broMide -β-

2-Acetoxy-N,N,N-trimethylpropan-1-aminium bromide

(2-HYDROXYPROPYL)TRIMET

2(Acetyloxy)-N,N,N-triMethyl-1-propanaMiniuM broMide

TriMethyl-β-acetoxypropylaMMoniuM broMide

O-Acetyl-beta-methylcholine Bromide Mecholyl Bromide

MethacholineBromide&gt

333-31-3

CH3CO2CHCH3CH2NCH33Br

C8H18NO2Br

BrC8H18NO2

Quaternary Ammonium Compounds

Ammonium Bromides (Quaternary)

Quaternary Ammonium Compounds

Substrates