PROXYPHYLLINE
- Product Name
- PROXYPHYLLINE
- CAS No.
- 603-00-9
- Chemical Name
- PROXYPHYLLINE
- Synonyms
- MT;7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;Spasmolysin;PROXYPHYLINE;Thean;Theon;Brontyl;Spantin;Theoden;Sigophyl
- CBNumber
- CB7492824
- Molecular Formula
- C10H14N4O3
- Formula Weight
- 238.24
- MOL File
- 603-00-9.mol
PROXYPHYLLINE Property
- Melting point:
- 134-136°C
- Boiling point:
- 487.2±51.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml - form
- Solid
- pka
- 14.55±0.20(Predicted)
- color
- White to Off-White
- Water Solubility
- 285.7g/L(temperature not stated)
- Merck
- 14,7905
- InChI
- InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
- InChIKey
- KYHQZNGJUGFTGR-UHFFFAOYSA-N
- SMILES
- N1(CC(O)C)C2=C(N(C)C(=O)N(C)C2=O)N=C1
- CAS DataBase Reference
- 603-00-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Proxyphylline(603-00-9)
N-Bromosuccinimide Price
- Product number
- S351288
- Product name
- 7-(2-HYDROXYPROPYL)THEOPHYLLINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- P3800000
- Product name
- Proxyphylline
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 100 mg
- Price
- $225
- Updated
- 2025/07/31
- Product number
- S351288
- Product name
- 7-(2-HYDROXYPROPYL)THEOPHYLLINE
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- P3800000
- Product name
- Proxyphylline
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- p3800000
- Price
- $220
- Updated
- 2024/03/01
- Product number
- H1430
- Product name
- 7-(2-Hydroxypropyl)theophylline
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $74
- Updated
- 2025/07/31
PROXYPHYLLINE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A metabolite of Theophylline in human plasma.
Definition
ChEBI: Proxyphylline is an oxopurine.
Biological Activity
ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.
in vitro
previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].
in vivo
in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].
Purification Methods
Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]
References
[1] BRUNS R F. Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts[J]. Biochemical pharmacology, 1981, 30 4: Pages 325-333. DOI: 10.1016/0006-2952(81)90062-9
[2] KEISUKE TAKEDA . EFFECTS OF AMINOPHYLLINE, PROXYPHYLLINE AND A PROXYPHYLINE-MELILOTUS EXTRACT-RUTIN MIXTURE (THEOESBERIVEN) ON THE HEART AND THE CORONARY CIRCULATION[J]. Japanese journal of pharmacology, 1977, 27 5: Pages 709-720. DOI: 10.1254/jjp.27.709
[3] LUCYNA KORZYCKA Dorota G. Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline.[J]. Journal of Pharmacy and Pharmacology, 2008, 60 5: 637-645. DOI: 10.1211/jpp.60.5.0010
[4] KNUT DALAKER Hans P. Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo[J]. Biochemical pharmacology, 1986, 35 20: Pages 3433-3439. DOI: 10.1016/0006-2952(86)90609-x
PROXYPHYLLINE Preparation Products And Raw materials
Raw materials
Preparation Products
PROXYPHYLLINE Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from PROXYPHYLLINE manufacturers
- Product
- Proxyphylline BP 603-00-9
- Price
- US $35.65/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-11-24
- Product
- Proxyphylline or 7-(2-Hydroxypropyl) Theophylline) 603-00-9
- Price
- US $35.66/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-11-24
- Product
- Monophylline, Spasmolysin 603-00-9
- Price
- US $35.67/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-11-24