PROXYPHYLLINE

ChemicalBook > CAS DataBase List > PROXYPHYLLINE

Product Name: PROXYPHYLLINE
CAS No.: 603-00-9
Chemical Name: PROXYPHYLLINE
Synonyms: MT;7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;Spasmolysin;PROXYPHYLINE;Thean;Theon;Brontyl;Spantin;Theoden;Sigophyl
CBNumber: CB7492824
Molecular Formula: C10H14N4O3
Formula Weight: 238.24
MOL File: 603-00-9.mol

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PROXYPHYLLINE Property

Melting point:: 134-136°C
Boiling point:: 487.2±51.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 14.55±0.20(Predicted)
form: Solid
color: White to Off-White
Water Solubility: 285.7g/L(temperature not stated)
Merck: 14,7905
InChI: InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
InChIKey: KYHQZNGJUGFTGR-UHFFFAOYSA-N
SMILES: N1(CC(O)C)C2=C(N(C)C(=O)N(C)C2=O)N=C1
CAS DataBase Reference: 603-00-9(CAS DataBase Reference)
NIST Chemistry Reference: Proxyphylline(603-00-9)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: XH5907500
HS Code: 2939.59.0000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S351288
Product name: 7-(2-HYDROXYPROPYL)THEOPHYLLINE
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: P3800000
Product name: Proxyphylline
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: p3800000
Price: $220
Updated: 2024/03/01

TCI Chemical

Product number: H1430
Product name: 7-(2-Hydroxypropyl)theophylline
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $78
Updated: 2024/03/01

TCI Chemical

Product number: H1430
Product name: 7-(2-Hydroxypropyl)theophylline
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $196
Updated: 2024/03/01

Cayman Chemical

Product number: 20937
Product name: Proxyphylline
Purity: ≥98%
Packaging: 500mg
Price: $49
Updated: 2024/03/01

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PROXYPHYLLINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Theophylline in human plasma.

Definition

ChEBI: Proxyphylline is an oxopurine.

Biological Activity

ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.

in vitro

previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].

in vivo

in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].

Purification Methods

Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]

References

[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55.

PROXYPHYLLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PROXYPHYLLINE manufacturers

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Proxyphylline BP 603-00-9
Price: US $35.65/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2023-11-24

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Proxyphylline or 7-(2-Hydroxypropyl) Theophylline) 603-00-9
Price: US $35.66/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2023-11-24

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Monophylline, Spasmolysin 603-00-9
Price: US $35.67/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2023-11-24

603-00-9, PROXYPHYLLINERelated Search:

Monophylline, Spasmolysin

Proxyphylline or 7-(2-Hydroxypropyl) Theophylline)

Diprophylline Impurity 4（Diprophylline EP Impurity D）

7-(BETA-HYDROXYPROPYL)THEOPHYLLINE

[1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE]

7-(B-hydroxypropyl)theophylline

Proxylphylline

Proxyphylline BP

1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl- (9CI)

2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine

7-(b-Hydroxypropyl)-1,3-dimethylxanthine

7-(2-hydroxypropyl)-theophyllin

7-(2-Hydroxypropyl)theophylline

7-(beta-Hydroxypropyl)-1,3-dimethylxanthine

beta-Hydroxypropyltheophylline

beta-Oxypropyltheophyllin

Brontyl

Hydroxypropyltheophylline

Monophylline

Oxypropyltheophylline

Proxiphylline

Proxy-Retardoral

Purophyllin

Sanwaphyllin

Sigophyl

Spantin

Spasmolysin

Thean

Theoden

Theon

Theophylline, 7-(2-hydroxypropyl)-

PROXYPHYLINE

PROXYPHYLLIN

PROXYPHYLLINE

Diprophylline EP Impurity D

1,3-Dimethyl-7-(2-hydroxypropyl)xanthine

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-

1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-

2-Hydroxypropyl-7-theophylline

3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-1h-purine-6-dione

3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione

3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1h-purine-6-dione

7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

b-Hydroxypropyltheophylline

NSC 163343

Theophylline, 7-(2-hydroxypropyl)- (6CI, 7CI, 8CI)

7-(BETA-HYDROXYPROPYL)-THEOPHYLLINE 99% BP2003

(1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine), Proxyphylline

7-(2-hydroxypropyl)-1,3-dimethyl-purine-2,6-dione

7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione

7-(2-hydroxypropyl)-1,3-dimethyl-xanthine

7-(2-Hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

7-(2-Hydroxypropyl)theophylline&gt

Proxyphylline CRS

7-(β-Hydroxypropyl)theophylline

Pentoxifylline Impurity 1

7-[(2RS)-2-hydroxypropyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (proxyphylline).