4-FLUORO-3-NITROBENZYL ALCOHOL 96
- Product Name
- 4-FLUORO-3-NITROBENZYL ALCOHOL 96
- CAS No.
- 20274-69-5
- Chemical Name
- 4-FLUORO-3-NITROBENZYL ALCOHOL 96
- Synonyms
- (4-Fluoro-3-nitrophenyl)methanol;Benzenemethanol, 4-fluoro-3-nitro-;4-Fluoro-3-nitrobenzyl alcohol 96%;4-FLUORO-3-NITROBENZYL ALCOHOL 96
- CBNumber
- CB7500271
- Molecular Formula
- C7H6FNO3
- Formula Weight
- 171.13
- MOL File
- 20274-69-5.mol
4-FLUORO-3-NITROBENZYL ALCOHOL 96 Property
- Melting point:
- 39-44 °C (lit.)
- Boiling point:
- 333.7±27.0 °C(Predicted)
- Density
- 1.434
- Flash point:
- 230 °F
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.37±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- 526916
- Product name
- 4-Fluoro-3-nitrobenzyl alcohol
- Purity
- 96%
- Packaging
- 5g
- Price
- $168
- Updated
- 2023/06/20
- Product number
- F594705
- Product name
- 4-Fluoro-3-nitrobenzyl alcohol
- Packaging
- 25g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- PC502598
- Product name
- 4-Fluoro-3-nitrobenzyl alcohol
- Packaging
- 25g
- Price
- $537
- Updated
- 2021/12/16
- Product number
- 4654-3-8C
- Product name
- 4-Fluoro-3-nitrobenzyl alcohol
- Packaging
- 25g
- Price
- $592
- Updated
- 2021/12/16
- Product number
- CS-W017657
- Product name
- 4-Fluoro-3-nitrobenzyl alcohol
- Packaging
- 100g
- Price
- $595
- Updated
- 2021/12/16
4-FLUORO-3-NITROBENZYL ALCOHOL 96 Chemical Properties,Usage,Production
Uses
4-Fluoro-3-nitrobenzyl Alcohol is used as a reagent in the preparation of EW-7197 (E950000) which is a highly potent orally bioavailable inhibitor of TGF-β type I receptor kinase that is used in cancer treatment as an immunotherapeutic or antifibrotic agent.
Uses
4-Fluoro-3-nitrobenzyl alcohol may be used in the synthesis of 4-fluoro-3-nitrobenzyl chloride.
General Description
4-Fluoro-3-nitrobenzyl alcohol can be prepared from the reaction between borane (in THF) and 4-fluoro-3-nitrobenzoic acid (in THF) at 0°C.
Synthesis
453-71-4
20274-69-5
The general procedure for the synthesis of 3-nitro-4-fluorobenzyl alcohol from 4-fluoro-3-nitrobenzoic acid was as follows: sodium borohydride (2.70 g, 64.83 mmol) was dissolved in 100 mL of tetrahydrofuran and cooled to 0 °C. 4-Fluoro-3-nitrobenzoic acid (12.0 g, 64.83 mmol) was added in batches at 0 °C and the addition process lasted for 1 hour. Subsequently, boron trifluoride diethyl ether solution (6.55 mL, 71.31 mmol) was added dropwise at 0 °C. The reaction mixture was slowly warmed to room temperature and stirring was continued for 3 hours. Upon completion of the reaction, 500 mL of ethyl acetate and 300 mL of water were added to the mixture, which was layered and the organic phase was collected. The organic phase was washed with 500 mL of saturated sodium chloride solution and then dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated under reduced pressure to give 3-nitro-4-fluorobenzyl alcohol (11.0 g, light yellow solid) in 99.1% yield.
References
[1] Patent: CN107400092, 2017, A. Location in patent: Paragraph 0293; 0295-0298
[2] Patent: CN108264511, 2018, A. Location in patent: Paragraph 0280; 0283-0286
[3] Patent: WO2012/171488, 2012, A1. Location in patent: Page/Page column 22-23
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 23, p. 5546 - 5550
[5] Patent: WO2017/89453, 2017, A1. Location in patent: Page/Page column 54
4-FLUORO-3-NITROBENZYL ALCOHOL 96 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUORO-3-NITROBENZYL ALCOHOL 96 manufacturers
- Product
- 4-FLUORO-3-NITROBENZYL ALCOHOL 96 20274-69-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-08