(S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID

Product Name: (S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID
CAS No.: 190897-47-3
Chemical Name: (S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID
Synonyms: (s)-boc-β2-homoala-oh;Boc-S-3-Aminoisobutyric acid;(S)-Boc-β2-HomoAla-OH≥ 99% (TLC);Boc-(S)-3-AMino-2-Methylpropanoic acid;(S)-N-Boc-3-amino-2-methylpropionic Acid;(2S)-3-(Boc-amino)-2-methyl-propanoic acid;(S)-3-(Boc-amino)-2-methylpropionic acid;(S)-3-(tert-ButoxycarbonylaMino)-2-Methylpropanoic acid;(Tert-Butoxy)Carbonyl (S)-3-Amino-2-methylpropanoic acid;Boc-S-3-AMinoisobutyric acid Boc-S-3-AMinoisobutyric acid
CBNumber: CB7502619
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 190897-47-3.mol

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(S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID Property

Melting point:: 88 °C(lit.)
Boiling point:: 339.5±25.0 °C(Predicted)
Density: 1.101±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 4.53±0.10(Predicted)
Appearance: White to off-white Solid
optical activity: [α]20/D +12±2°, c = 1% in DMF
BRN: 8037279
InChI: InChI=1S/C9H17NO4/c1-6(7(11)12)5-10-8(13)14-9(2,3)4/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m0/s1
InChIKey: GDQRNRYMFXDGMS-LURJTMIESA-N
SMILES: C(O)(=O)[C@@H](C)CNC(OC(C)(C)C)=O

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Safety

WGK Germany: 3
F: 3-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B630305
Product name: (S)-3-(Boc-amino)-2-methylpropionic acid
Packaging: 50mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49836
Product name: (S)-3-(Boc-amino)-2-methylpropionic acid
Packaging: 10mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49836
Product name: (S)-3-(Boc-amino)-2-methylpropionic acid
Packaging: 25mg
Price: $100
Updated: 2021/12/16

Chem-Impex

Product number: 14283
Product name: (S)-Boc-β2-HomoAla-OH,99%(TLC)
Purity: 99%(TLC)
Packaging: 100MG
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49836
Product name: (S)-3-(Boc-amino)-2-methylpropionic acid
Packaging: 50mg
Price: $160
Updated: 2021/12/16

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(S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

168828-18-0

190897-47-3

The general procedure for the synthesis of (S)-3-((tert-butoxycarbonyl)amino)-2-methylpropanoic acid using tert-butyl (S)-2-(methoxycarbonyl)propylcarbamate as a raw material was as follows: firstly, 1.30 g (5.98 mmol) of (2S)-3-[(tert-butoxycarbonyl)amino]-2-methylpropanoic acid methyl ester was dissolved in 16 mL of tetrahydrofuran and 4 mL of distilled water in a mixed in the solvent. Subsequently, 0.75 g (18.0 mmol) of lithium hydroxide was added and the reaction was stirred at room temperature for 15 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure, ethyl acetate was added, the reaction solution was neutralized with 1N HCl, and the organic phase was dried with magnesium sulfate. After that, the solvent was removed by distillation and the residue was purified by column chromatography to give 1.05 g of the target compound in 87% yield. Next, the resulting compound was dissolved in 20 mL of diethyl ether and cooled to -30°C. At this temperature, 0.82 mL (5.90 mmol) of triethylamine and 0.78 mL (5.90 mmol) of isobutyl chloroformate were added sequentially. After stirring for 15 minutes, diazomethane dissolved in diethyl ether was slowly added (in excess). After continued stirring for 2 hours, acetic acid and ethyl acetate were added sequentially and the reaction solution was washed with sodium carbonate solution and water. The organic phase was dried and the residue was purified by column chromatography to give 0.31 g of (S)-3-((tert-butoxycarbonyl)amino)-2-methylpropanoic acid in 28% yield. The product was confirmed by 1H NMR (CDCl3): δ 5.35 (1H, s), 5.01 (1H, s), 3.28 (2H, t, J=6Hz), 2.71 (1H, m), 1.45 (9H, s), 1.15 (3H, d, J=6.8Hz). Mass spectral analysis showed m/e of 228 (M+1).

References

[1] Patent: WO2008/93960, 2008, A1. Location in patent: Page/Page column 25-26

(S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID Suppliers

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View Lastest Price from (S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID manufacturers

Career Henan Chemical Co

Product: (S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID 190897-47-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-25

Career Henan Chemical Co

Product: Hydrocortisone sodium phosphate 190897-47-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-25

190897-47-3, (S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACIDRelated Search:

2-(N,N-DIMETHYLAMINOMETHYL)PHENYLBORONIC ACID (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-AMCP-OH 1-N-Boc-3-Azetidinecarboxylic acid L-1-Boc-Nipecotic acid 1-[(TERT-BUTYL)OXYCARBONYL]-4-PHENYLPYRROLINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-4-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE-3-CARBOXYLIC ACID BOC-3-EXO-AMINOBICYCLO[2.2.1]HEPTANE-2-EXO-CARBOXYLIC ACID trans-1-Boc-4-(4-chlorophenyl)-3-pyrrolidinecarboxylic acid (1S,2R)-BOC-2-AMINOCYCLOHEXANE CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-4-(2-CHLOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID (1S,2S)-BOC-2-AMINOCYCLOPENTANE CARBOXYLIC ACID BOC-S-AMBA-OH 2S,3S-1-BOC-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID (1S,2S)-BOC-2-AMINOCYCLOHEXANE CARBOXYLIC ACID (S)-3-(BOC-AMINO)-2-METHYLPROPIONIC ACID BOC-3-EXO-AMINOBICYCLO[2.2.1]HEPT-5-ENE-2-EXO-CARBOXYLIC ACID CIS-2-TERT-BUTOXYCARBONYLAMINO-2-METHYL-CYCLOHEXANECARBOXYLIC ACID

Boc-S-3-Aminoisobutyric acid

Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S)- (9CI)

(s)-boc-β2-homoala-oh

2S-METHYL-3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-PROPANOIC ACID

(S)-3-(tert-ButoxycarbonylaMino)-2-Methylpropanoic acid

Boc-S-3-AMinoisobutyric acid Boc-S-3-AMinoisobutyric acid

Boc-(S)-3-AMino-2-Methylpropanoic acid

(S)-3-(Boc-aMino)-2-Methylpropionic acid

(S)-3-(Boc-amino)-2-methylpropionic acid

(S)-Boc-β2-HomoAla-OH≥ 99% (TLC)

(Tert-Butoxy)Carbonyl (S)-3-Amino-2-methylpropanoic acid

(2S)-3-{[(tert-butoxy)carbonyl]amino}-2-methylpropanoic acid

Propanoic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S)-

(S)-N-Boc-3-amino-2-methylpropionic Acid

(2S)-3-(Boc-amino)-2-methyl-propanoic acid

(2S)-2-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

(S)-3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid - [B91859]

190897-47-3

19087-47-3

CH33CO2CNHCH2CHCH3CO2H

N-BOC