L-1-Boc-Nipecotic acid

Product Name: L-1-Boc-Nipecotic acid
CAS No.: 88495-54-9
Chemical Name: L-1-Boc-Nipecotic acid
Synonyms: (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID;BOC-(S)-NIPECOTIC ACID;(S)-1-BOC-PIPERIDINE-3-CARBOXYLIC ACID;PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;BOC-NIP;BOC-NIP-OH;(S)-BOC-NIP;BOC-L-NIP-OH;BOC-DL-NIP-OH;BOC-(S)-NIP-OH
CBNumber: CB9854558
Molecular Formula: C11H19NO4
Formula Weight: 229.27
MOL File: 88495-54-9.mol

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L-1-Boc-Nipecotic acid Property

Melting point:: 159-162 °C(lit.)
Boiling point:: 353.2±35.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.49±0.20(Predicted)
form: solid
color: White to off-white
optical activity: [α]22/D +57°, c = 1 in chloroform
InChI: InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1
InChIKey: NXILIHONWRXHFA-QMMMGPOBSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@H](C(O)=O)C1
CAS DataBase Reference: 88495-54-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-50
Safety Statements: 26-36-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Acute 1
Aquatic Chronic 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681229
Product name: (S)-1-Boc-piperidine-3-carboxylic acid
Purity: 97%
Packaging: 500mg
Price: $107
Updated: 2026/04/30

Usbiological

Product number: 261872
Product name: N-Boc-(S)-Nipecotic acid
Purity: Asreported
Packaging: 1g
Price: $322
Updated: 2026/06/03

Usbiological

Product number: 261872
Product name: N-Boc-(S)-Nipecotic acid
Purity: Asreported
Packaging: 2g
Price: $423
Updated: 2026/06/03

Usbiological

Product number: 261872
Product name: N-Boc-(S)-Nipecotic acid
Purity: Asreported
Packaging: 5g
Price: $575
Updated: 2026/06/03

Usbiological

Product number: 261872
Product name: N-Boc-(S)-Nipecotic acid
Purity: Asreported
Packaging: 10g
Price: $758
Updated: 2026/06/03

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L-1-Boc-Nipecotic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

1-Boc-L-nipecotic acid is used as an organic chemical synthesis intermediate.

Synthesis

24424-99-5

498-95-3

71381-75-4

The general procedure for the synthesis of 1-BOC-piperidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-piperidinecarboxylic acid was as follows: 1. To a solution of piperidine-3-carboxylic acid (50.0 g, 387.5 mmol) in tert-butanol (464.0 mL) was slowly added 1N NaOH solution (464.0 mL) at 0 °C and stirred for 10 min. 2. Di-tert-butyl dicarbonate (Boc-anhydride, 143.6 g, 659.0 mmol) was then added. 3. The reaction mixture was stirred continuously at room temperature for 12 hours. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and then neutralized to neutrality with 1N HCl solution. 5. The precipitated solid product was collected by filtration and dried to give 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1, 86.0 g, 97% yield) as a white solid. Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ 1.38 (s, 9H), 1.47 (m, 1H), 1.59 (dt, J = 3.8 Hz, 1H), 1.87 (m, 1H), 2.28 (m, 1H), 2.77-2.84 (dt, J = 2.5,3.0 Hz, 1H), 3.0 (brs. 1H), 3.67 (d, J = 11.0 Hz, 1H), 3.87 (brs, 1H), 12.2 (s, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2118 - 2122
[2] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00604
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1719 - 1728
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 966 - 973
[5] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682

L-1-Boc-Nipecotic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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L-1-Boc-Nipecotic acid Suppliers

Canada 1 China 196 Europe 2 France 1 Germany 4 India 4 Japan 2 Switzerland 1 United Kingdom 9 United States 45 Global 265

ITIC MEDCHEM(SUZHOU) CO.,LTD.

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View Lastest Price from L-1-Boc-Nipecotic acid manufacturers

.GZ HONESTCHEM CO.,LTD

Product: L-1-Boc-Nipecotic acid 88495-54-9
Price: US $1.00/g
Min. Order: 300g
Purity: 99.8%
Supply Ability: 20 TONS
Release date: 2025-12-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-1-Boc-Nipecotic acid 88495-54-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: L-1-Boc-Nipecotic acid 88495-54-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-12

88495-54-9, L-1-Boc-Nipecotic acidRelated Search:

DROPERIDOL Di-tert-butyl dicarbonate Folic acid Ethyl 2-(Chlorosulfonyl)acetate Haloperidol PHENCYCLIDINE-D5 HYDROCHLORIDE 2,2,6,6-Tetramethyl-4-piperidinol Glycine DL-Nipecotic acid (R)-3-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI) 1-Boc-3-piperidinecarboxylic acid Piperidine Diphenoxylate N-Boc-nipecotic acid methyl ester N-BOC-DL-PIPECOLINIC ACID 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

N-T-BUTOXYCARBONYL-DL-3-PIPERIDINECARBOXYLIC ACID

N-T-BUTOXYCARBONYL-DL-NIPECOTIC ACID

N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID

N-T-BUTOXYCARBONYL-(R,S)-NIPECOTIC ACID

N-T-BUTOXYCARBONYL-(R,S)-PIPERIDINE-3-CARBOXYLIC ACID

(S)-1-Boc-Nipecoticacid

(S)-T-BUTYLOXYCARBONYL-NIPECOTIC ACID: (S)-N-T-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

N-ALPHA-T-BOC-3-CARBOXYPIPERIDINE

N-BOC-DL-NIPECOTIC ACID

(+/-)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

BOC-3-CARBOXYPIPERIDINE

BOC-NIP

BOC-NIP-OH

BOC-L-NIP-OH

BOC-(R,S)-NIP-OH

BOC-(R,S)-NIPECOTIC ACID

BOC-(S)-PIPERIDINE-3-CARBOXYLIC ACID

BOC-(S)-NIP-OH

(S)-Boc-Nip-OH, (S)-Boc-nipecotic acid

(S)-N-t-Butyloxycarbonyl-Nipecotic Acid, (S)-N-t-Butyloxycarbonyl-piperidine-3-carboxylic acid

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)-

(3S)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic acid

(3S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid

(3S)-1-[[(1,1-Dimethylethyl)oxy]carbonyl]-3-piperidinecarboxylic acid

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)- (9CI)

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (S)-

1-Boc-L-nipecotic acid, 97%

Boc-L-nipecotic acid

Boc-Nip-OH, Boc-(S)-piperidine-3-carboxylic acid

N-Boc-(S)-Nipecotic acid 97%

PIPERIDINE-3-CARBOXYLIC ACID, BOC PROTECTED

(R,S)-N-TERT-BUTYLOXYCARBONYL-NIPECOTIC ACID

(R,S)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

(R,S)-BOC-NIPECOTIC ACID

(S)-1-BOC-3-PIPERIDINECARBOXYLIC ACID

(S)-BOC-NIP

(S)-BOC-NIPECOTIC ACID

(s)-boc-nip-oh

(S)-N-T-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

(S)-N-TERT-BUTYLOXYCARBONYL-NIPECOTIC ACID

(S)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

(S)-(+)-N-BOC-NIPECOTIC ACID

(S)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

(S)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

(S)-T-BUTYLOXYCARBONYL-NIPECOTIC ACID

RAC 1-TERT-BUTOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

RAC 1-BOC-PIPERIDINE-3-CARBOXYLIC ACID

RARECHEM EM WB 0154

N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

N-BOC-(S)-NIPECOTIC ACID

N-BOC-3-PIPERIDINECARBOXYLIC ACID

1-BOC-PIPERIDINE-3-CARBOXYLIC ACID

1-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXYLIC ACID

L-1-BOC-NIPECOTIC ACID

BOC-DL-NIP-OH

BOC-DL-NIPC-OH

BOC-DL-NIPECOTIC ACID