L-1-Boc-Nipecotic acid
- Product Name
- L-1-Boc-Nipecotic acid
- CAS No.
- 88495-54-9
- Chemical Name
- L-1-Boc-Nipecotic acid
- Synonyms
- BOC-NIP;BOC-NIP-OH;(S)-BOC-NIP;BOC-L-NIP-OH;BOC-DL-NIP-OH;BOC-(S)-NIP-OH;(s)-boc-nip-oh;BOC-DL-NIPC-OH;BOC-(R,S)-NIP-OH;BOC-DL-PIC(3)-OH
- CBNumber
- CB9854558
- Molecular Formula
- C11H19NO4
- Formula Weight
- 229.27
- MOL File
- 88495-54-9.mol
L-1-Boc-Nipecotic acid Property
- Melting point:
- 159-162 °C(lit.)
- Boiling point:
- 353.2±35.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.49±0.20(Predicted)
- form
- solid
- color
- White to off-white
- optical activity
- [α]22/D +57°, c = 1 in chloroform
- InChI
- InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1
- InChIKey
- NXILIHONWRXHFA-QMMMGPOBSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@H](C(O)=O)C1
- CAS DataBase Reference
- 88495-54-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-50
- Safety Statements
- 26-36-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 681229
- Product name
- (S)-1-Boc-piperidine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 500mg
- Price
- $50
- Updated
- 2025/07/31
- Product number
- B663373
- Product name
- (S)-1-Boc-piperidine-3-carboxylic acid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B663373
- Product name
- (S)-1-Boc-piperidine-3-carboxylic acid
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 265574
- Product name
- Boc-DL-nipecotic acid
- Packaging
- 25g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- J99003
- Product name
- (S)-N-Boc-piperidine-3-carboxylicacid
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
L-1-Boc-Nipecotic acid Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
1-Boc-L-nipecotic acid is used as an organic chemical synthesis intermediate.
Synthesis
24424-99-5
498-95-3
71381-75-4
The general procedure for the synthesis of 1-BOC-piperidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-piperidinecarboxylic acid was as follows: 1. To a solution of piperidine-3-carboxylic acid (50.0 g, 387.5 mmol) in tert-butanol (464.0 mL) was slowly added 1N NaOH solution (464.0 mL) at 0 °C and stirred for 10 min. 2. Di-tert-butyl dicarbonate (Boc-anhydride, 143.6 g, 659.0 mmol) was then added. 3. The reaction mixture was stirred continuously at room temperature for 12 hours. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and then neutralized to neutrality with 1N HCl solution. 5. The precipitated solid product was collected by filtration and dried to give 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1, 86.0 g, 97% yield) as a white solid. Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ 1.38 (s, 9H), 1.47 (m, 1H), 1.59 (dt, J = 3.8 Hz, 1H), 1.87 (m, 1H), 2.28 (m, 1H), 2.77-2.84 (dt, J = 2.5,3.0 Hz, 1H), 3.0 (brs. 1H), 3.67 (d, J = 11.0 Hz, 1H), 3.87 (brs, 1H), 12.2 (s, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2118 - 2122
[2] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00604
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1719 - 1728
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 966 - 973
[5] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
L-1-Boc-Nipecotic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-1-Boc-Nipecotic acid manufacturers
- Product
- L-1-Boc-Nipecotic acid 88495-54-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- L-1-Boc-Nipecotic acid 88495-54-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-12