ChemicalBook > CAS DataBase List > L-1-Boc-Nipecotic acid

L-1-Boc-Nipecotic acid

Product Name
L-1-Boc-Nipecotic acid
CAS No.
88495-54-9
Chemical Name
L-1-Boc-Nipecotic acid
Synonyms
BOC-NIP;BOC-NIP-OH;(S)-BOC-NIP;BOC-L-NIP-OH;BOC-DL-NIP-OH;BOC-(S)-NIP-OH;(s)-boc-nip-oh;BOC-DL-NIPC-OH;BOC-(R,S)-NIP-OH;BOC-DL-PIC(3)-OH
CBNumber
CB9854558
Molecular Formula
C11H19NO4
Formula Weight
229.27
MOL File
88495-54-9.mol
More
Less

L-1-Boc-Nipecotic acid Property

Melting point:
159-162 °C(lit.)
Boiling point:
353.2±35.0 °C(Predicted)
Density 
1.164±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
4.49±0.20(Predicted)
form 
solid
color 
White to off-white
optical activity
[α]22/D +57°, c = 1 in chloroform
InChI
InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1
InChIKey
NXILIHONWRXHFA-QMMMGPOBSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC[C@H](C(O)=O)C1
CAS DataBase Reference
88495-54-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-50
Safety Statements 
26-36-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681229
Product name
(S)-1-Boc-piperidine-3-carboxylic acid
Purity
97%
Packaging
500mg
Price
$50
Updated
2025/07/31
Usbiological
Product number
265574
Product name
Boc-DL-nipecotic acid
Packaging
25g
Price
$333
Updated
2021/12/16
TRC
Product number
B663373
Product name
(S)-1-Boc-piperidine-3-carboxylic acid
Packaging
2.5g
Price
$75
Updated
2021/12/16
TRC
Product number
B663373
Product name
(S)-1-Boc-piperidine-3-carboxylic acid
Packaging
500mg
Price
$60
Updated
2021/12/16
Activate Scientific
Product number
AS31713
Product name
(S)-N-Boc-Piperidine-3-carboxylic acid
Purity
97+% ee
Packaging
5G
Price
$61
Updated
2021/12/16
More
Less

L-1-Boc-Nipecotic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

1-Boc-L-nipecotic acid is used as an organic chemical synthesis intermediate.

Synthesis

24424-99-5

498-95-3

71381-75-4

The general procedure for the synthesis of 1-BOC-piperidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-piperidinecarboxylic acid was as follows: 1. To a solution of piperidine-3-carboxylic acid (50.0 g, 387.5 mmol) in tert-butanol (464.0 mL) was slowly added 1N NaOH solution (464.0 mL) at 0 °C and stirred for 10 min. 2. Di-tert-butyl dicarbonate (Boc-anhydride, 143.6 g, 659.0 mmol) was then added. 3. The reaction mixture was stirred continuously at room temperature for 12 hours. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and then neutralized to neutrality with 1N HCl solution. 5. The precipitated solid product was collected by filtration and dried to give 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1, 86.0 g, 97% yield) as a white solid. Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ 1.38 (s, 9H), 1.47 (m, 1H), 1.59 (dt, J = 3.8 Hz, 1H), 1.87 (m, 1H), 2.28 (m, 1H), 2.77-2.84 (dt, J = 2.5,3.0 Hz, 1H), 3.0 (brs. 1H), 3.67 (d, J = 11.0 Hz, 1H), 3.87 (brs, 1H), 12.2 (s, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2118 - 2122
[2] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00604
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1719 - 1728
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 966 - 973
[5] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682

L-1-Boc-Nipecotic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

L-1-Boc-Nipecotic acid Suppliers

Canada 1 China 196 Europe 2 France 1 Germany 4 India 4 Japan 2 Switzerland 1 United Kingdom 9 United States 46 Global 266
ITIC MEDCHEM(SUZHOU) CO.,LTD.
Tel
0512-68323967 18015559028
Fax
+86-512-69200360
Email
sales@iticmedchem.com
Country
China
ProdList
506
Advantage
61
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.
Tel
21-54820552 18964669552
Fax
086-21-64964478
Email
188738128@qq.com
Country
China
ProdList
310
Advantage
66
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.
Tel
028-85755578 18140172005
Fax
028-85755578
Email
sales@aminotp.com
Country
China
ProdList
298
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Sichuan Guanghan Bio-Tech Co., Ltd
Tel
+86-28-86127071
Fax
+86-28-86127072
Email
info@sino-produce.com
Country
China
ProdList
406
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
1009
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
shanghai cooperpharm co.,LTD .
Tel
+86-021-58975553
Fax
+86-021-58975554
Email
sales@cooperpharm.com
Country
China
ProdList
1210
Advantage
56
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Suzhou Ryan Pharmachem Technology Co.,Ltd
Tel
0512-66585217 13962137180
Fax
0512-82177549
Email
sales@ryanchem.com
Country
China
ProdList
384
Advantage
55
Shanghai Synmedia Chemical Co., Ltd.
Tel
021-38681880 13817889927
Fax
0213390-8196
Email
sales@synmedia-chem.com
Country
China
ProdList
249
Advantage
58
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
15928766785 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
1987
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Shanghai Hobor Chemical Co., Ltd
Tel
021-57790084; 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
392
Advantage
60
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
1941
Advantage
62
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
More
Less

View Lastest Price from L-1-Boc-Nipecotic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
L-1-Boc-Nipecotic acid 88495-54-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
L-1-Boc-Nipecotic acid 88495-54-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-12

88495-54-9, L-1-Boc-Nipecotic acidRelated Search:

DROPERIDOL Di-tert-butyl dicarbonate Folic acid Nipecotic acid 2,2,6,6-Tetramethyl-4-piperidinol Ethyl 2-(Chlorosulfonyl)acetate Haloperidol PHENCYCLIDINE-D5 HYDROCHLORIDE Glycine 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3S)- (9CI) (R)-3-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID Piperidine Diphenoxylate 1-Boc-3-piperidinecarboxylic acid N-Boc-nipecotic acid methyl ester N-BOC-DL-PIPECOLINIC ACID 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

  • N-T-BUTOXYCARBONYL-DL-3-PIPERIDINECARBOXYLIC ACID
  • N-T-BUTOXYCARBONYL-DL-NIPECOTIC ACID
  • N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID
  • N-T-BUTOXYCARBONYL-(R,S)-NIPECOTIC ACID
  • N-T-BUTOXYCARBONYL-(R,S)-PIPERIDINE-3-CARBOXYLIC ACID
  • (S)-1-Boc-Nipecoticacid
  • (S)-T-BUTYLOXYCARBONYL-NIPECOTIC ACID: (S)-N-T-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID
  • N-ALPHA-T-BOC-3-CARBOXYPIPERIDINE
  • N-BOC-DL-NIPECOTIC ACID
  • (+/-)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID
  • BOC-3-CARBOXYPIPERIDINE
  • BOC-NIP
  • BOC-NIP-OH
  • BOC-L-NIP-OH
  • BOC-(R,S)-NIP-OH
  • BOC-(R,S)-NIPECOTIC ACID
  • BOC-(S)-PIPERIDINE-3-CARBOXYLIC ACID
  • BOC-(S)-NIPECOTIC ACID
  • BOC-(S)-NIP-OH
  • (S)-Boc-Nip-OH, (S)-Boc-nipecotic acid
  • (S)-N-t-Butyloxycarbonyl-Nipecotic Acid, (S)-N-t-Butyloxycarbonyl-piperidine-3-carboxylic acid
  • 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)-
  • (3S)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic acid
  • (3S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid
  • (3S)-1-[[(1,1-Dimethylethyl)oxy]carbonyl]-3-piperidinecarboxylic acid
  • 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)- (9CI)
  • 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (S)-
  • 1-Boc-L-nipecotic acid, 97%
  • Boc-L-nipecotic acid
  • Boc-Nip-OH, Boc-(S)-piperidine-3-carboxylic acid
  • N-Boc-(S)-Nipecotic acid 97%
  • PIPERIDINE-3-CARBOXYLIC ACID, BOC PROTECTED
  • PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID
  • (R,S)-N-TERT-BUTYLOXYCARBONYL-NIPECOTIC ACID
  • (R,S)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID
  • (R,S)-BOC-NIPECOTIC ACID
  • (S)-1-BOC-PIPERIDINE-3-CARBOXYLIC ACID
  • (S)-1-BOC-3-PIPERIDINECARBOXYLIC ACID
  • (S)-BOC-NIP
  • (S)-BOC-NIPECOTIC ACID
  • (s)-boc-nip-oh
  • (S)-N-T-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID
  • (S)-N-TERT-BUTYLOXYCARBONYL-NIPECOTIC ACID
  • (S)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID
  • (S)-(+)-N-BOC-NIPECOTIC ACID
  • (S)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID
  • (S)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • (S)-T-BUTYLOXYCARBONYL-NIPECOTIC ACID
  • RAC 1-TERT-BUTOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID
  • RAC 1-BOC-PIPERIDINE-3-CARBOXYLIC ACID
  • RARECHEM EM WB 0154
  • N-BOC-PIPERIDINE-3-CARBOXYLIC ACID
  • N-BOC-(S)-NIPECOTIC ACID
  • N-BOC-3-PIPERIDINECARBOXYLIC ACID
  • 1-BOC-PIPERIDINE-3-CARBOXYLIC ACID
  • 1-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID
  • 1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXYLIC ACID