1-Boc-3-piperidinecarboxylic acid

Product Name: 1-Boc-3-piperidinecarboxylic acid
CAS No.: 84358-12-3
Chemical Name: 1-Boc-3-piperidinecarboxylic acid
Synonyms: 1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID;1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXYLIC ACID;N-(tert-butyloxycarbonyl)nipecotic acid;BOC-NIP;BOC-NIP-OH;BOC-DL-NIP-OH;BOC-DL-NIPC-OH;BOC-(R,S)-NIP-OH;BOC-DL-PIC(3)-OH;N-BOC-nipecotic ac
CBNumber: CB9738692
Molecular Formula: C11H19NO4
Formula Weight: 229.27
MOL File: 84358-12-3.mol

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1-Boc-3-piperidinecarboxylic acid Property

Melting point:: 159-162 °C(lit.)
Boiling point:: 353.2±35.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.49±0.20(Predicted)
form: Crystalline Powder
color: White
BRN: 5539297
InChI: InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)
InChIKey: NXILIHONWRXHFA-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCC(C(O)=O)C1
CAS DataBase Reference: 84358-12-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3376
Product name: 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: B3376
Product name: 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $156
Updated: 2025/07/31

TRC

Product number: E926935
Product name: N-[(1-Ethyl-1H-pyrazol-4-yl)methyl]-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]amine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 038250
Product name: 1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid
Packaging: 5g
Price: $10
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK427134
Product name: 1-Boc-3-piperidinecarboxylicacid
Purity: 98%
Packaging: 1g
Price: $13
Updated: 2021/12/16

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1-Boc-3-piperidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

24424-99-5

498-95-3

71381-75-4

The general procedure for the synthesis of 1-BOC-piperidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-piperidinecarboxylic acid is as follows:1. Dissolve piperidine-3-carboxylic acid (50.0 g, 387.5 mmol) in tert-butyl alcohol (464.0 mL) at 0 °C, slowly add 1N NaOH solution (464.0 mL), and stir for 10 min. 2. Add di-tert-butyl dicarbonate (Boc-anhydride, 143.6 g, 659.0 mmol) to the above solution. 3. Stir the reaction mixture for 12 hours at room temperature. 4. Di-tert-butyl carbonate (Boc-anhydride, 143.6 g, 659.0 mmol) was added to the above solution. 3. The reaction mixture was stirred at room temperature for 12 h. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure, and then neutralized to pH neutral with 1N HCl solution. 5. The precipitated white solid was collected by filtration, and dried to give 1-BOC-piperidine-3-carboxylic acid (1 , 86.0 g, yield 97%). The product was characterized by 1H NMR (400 MHz, DMSO-d6), δ 1.38 (s, 9H), 1.47 (m, 1H), 1.59 (dt, J = 3.8 Hz, 1H), 1.87 (m, 1H), 2.28 (m, 1H), 2.77-2.84 (dt, J = 2.5,3.0 Hz, 1H), 3.0 (brs. 1H), 3.67 (d, J = 11.0 Hz, 1H), 3.87 (brs, 1H), 12.2 (s, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2118 - 2122
[2] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00604
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1719 - 1728
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 966 - 973
[5] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682

1-Boc-3-piperidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-piperidinecarboxylic acid Suppliers

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View Lastest Price from 1-Boc-3-piperidinecarboxylic acid manufacturers

Anhui Zhongda Biotechnology Co., Ltd

Product: 1-(tert-Butoxycarbonyl)nipecotic Acid 84358-12-3
Price: US $25.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 500tons
Release date: 2023-10-12

Anhui Zhongda Biotechnology Co., Ltd

Product: 1-(tert-Butoxycarbonyl)nipecotic Acid 84358-12-3
Price: US $50.00-40.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000/month
Release date: 2023-10-12

Xingtai Haoxun Import and Export Trade Co., Ltd.

Product: 1-Boc-3-piperidinecarboxylic acid 84358-12-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2020-07-16

84358-12-3, 1-Boc-3-piperidinecarboxylic acidRelated Search:

Nipecotic acid 2,2,6,6-Tetramethyl-4-piperidinol Haloperidol DROPERIDOL Folic acid Maleic acid 3,5-Dihydroxybenzoic acid Ethyl 2-(Chlorosulfonyl)acetate BOC-PIPERIDINE-4-CARBOXYLIC ACID,1-N-BOC-PIPERIDINE-4-CARBOXYLIC ACID,N-BOC-PIPERIDINE-4-CARBOXYLIC ACID,1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER Ethyl 1-Boc-piperidine-2-carboxylate Ethyl 1-Boc-3-piperidinecarboxylate N-BOC-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER N-Boc-2-piperidinecarboxylic acid 1-N-Boc-3-Methylpiperidine-3-carboxylic acid (3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Citric acid TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE

1-N-Boc-3-piperidinecarboxylicacid

(R,S)-N-T-BUTYLOXYCARBONYL-NIPECOTIC ACID, (R,S)-N-T-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

N-BOC-DL-NIPECOTIC ACID

(+/-)-N-BOC-NIPECOTIC ACID

N-BOC-NIPECOTIC ACID

(+/-)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

N-ALPHA-T-BOC-3-CARBOXYPIPERIDINE

N-T-BUTOXYCARBONYL-DL-NIPECOTIC ACID

N-T-BUTOXYCARBONYL-DL-3-PIPERIDINECARBOXYLIC ACID

N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID

N-T-BUTOXYCARBONYL-(R,S)-NIPECOTIC ACID

1-TERT-BUTOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID, RAC

N-tert-Butoxycarbonyl nipecotic acid

1－Boc-3-piperidinecarboxylic

rac-N-Boc-piperidine-3-carboxylicacid

N-BOC-3-Piperidinecarboxylic acid,98%

Boc-3-piperidinecarboxylic acid

1,3-Piperidinedicarboxylic acid 1-tert-butyl ester

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester (9CI)

1-t-Butoxycarbonyl-3-piperidinecarboxylic acid

1-tert-Butyl 1,3-piperidinedicarboxylate

N-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid

N-(tert-Butyloxycarbonyl)piperidine-3-carboxylic acid

N-BOC-nipecotic ac

1-BOC-NIPECOTIC ACID

N-Boc-Piperidine-3-carboxlic Acid

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester

(±)-N-Boc-piperidine-3-carboxylic acid, Boc-DL-nipecotic acid

1-(tert-Butoxycarbonyl)nipecotic Acid

China N-BOC-piperidine-3-carboxylic acid

China 1-Boc-3-piperidinecarboxylic Acid

N-(tert-butyloxycarbonyl)nipecotic acid

( /-)-N-BOC-NIPECOTIC ACID

N-T-BUTOXYCARBONYL-(R,S)-PIPERIDINE-3-CARBOXYLIC ACID

BOC-NIP-OH

BOC-NIP

BOC-(R,S)-NIPECOTIC ACID

BOC-(R,S)-NIP-OH

BOC-DL-PIC(3)-OH

BOC-DL-NIPECOTIC ACID

BOC-DL-NIPC-OH

BOC-DL-NIP-OH

BOC-3-CARBOXYPIPERIDINE

1-(BOC)-3-PIPERIDINE-CARBOXYLIC ACID

1-BOC-PIPERIDINE-3-CARBOXYLIC ACID

1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID

1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXYLIC ACID

1-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID

1-(tert-butoxycarbonyl)-3-piperidine-carboxylic A

Boc-DL-Nip-OH~N-(tert-Butoxycarbonyl)nipecotic acid~1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid

N-(tert-Butoxycarbonyl)nipecotic acid~1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid

Piperidine-3-carboxylic acid, N-BOC protected

RAC 1-BOC-PIPERIDINE-3-CARBOXYLIC ACID

RAC 1-TERT-BUTOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

RARECHEM EM WB 0154

(R,S)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID

(R,S)-N-TERT-BUTYLOXYCARBONYL-NIPECOTIC ACID