1-Boc-3-piperidinecarboxylic acid
- Product Name
- 1-Boc-3-piperidinecarboxylic acid
- CAS No.
- 84358-12-3
- Chemical Name
- 1-Boc-3-piperidinecarboxylic acid
- Synonyms
- 1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID;1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXYLIC ACID;N-(tert-butyloxycarbonyl)nipecotic acid;BOC-NIP;BOC-NIP-OH;BOC-DL-NIP-OH;BOC-DL-NIPC-OH;BOC-(R,S)-NIP-OH;BOC-DL-PIC(3)-OH;N-BOC-nipecotic ac
- CBNumber
- CB9738692
- Molecular Formula
- C11H19NO4
- Formula Weight
- 229.27
- MOL File
- 84358-12-3.mol
1-Boc-3-piperidinecarboxylic acid Property
- Melting point:
- 159-162 °C(lit.)
- Boiling point:
- 353.2±35.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.49±0.20(Predicted)
- form
- Crystalline Powder
- color
- White
- BRN
- 5539297
- InChI
- InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)
- InChIKey
- NXILIHONWRXHFA-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCCC(C(O)=O)C1
- CAS DataBase Reference
- 84358-12-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B3376
- Product name
- 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- B3376
- Product name
- 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- E926935
- Product name
- N-[(1-Ethyl-1H-pyrazol-4-yl)methyl]-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]amine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 038250
- Product name
- 1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- JK427134
- Product name
- 1-Boc-3-piperidinecarboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
1-Boc-3-piperidinecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
24424-99-5
498-95-3
71381-75-4
The general procedure for the synthesis of 1-BOC-piperidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-piperidinecarboxylic acid is as follows:1. Dissolve piperidine-3-carboxylic acid (50.0 g, 387.5 mmol) in tert-butyl alcohol (464.0 mL) at 0 °C, slowly add 1N NaOH solution (464.0 mL), and stir for 10 min. 2. Add di-tert-butyl dicarbonate (Boc-anhydride, 143.6 g, 659.0 mmol) to the above solution. 3. Stir the reaction mixture for 12 hours at room temperature. 4. Di-tert-butyl carbonate (Boc-anhydride, 143.6 g, 659.0 mmol) was added to the above solution. 3. The reaction mixture was stirred at room temperature for 12 h. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure, and then neutralized to pH neutral with 1N HCl solution. 5. The precipitated white solid was collected by filtration, and dried to give 1-BOC-piperidine-3-carboxylic acid (1 , 86.0 g, yield 97%). The product was characterized by 1H NMR (400 MHz, DMSO-d6), δ 1.38 (s, 9H), 1.47 (m, 1H), 1.59 (dt, J = 3.8 Hz, 1H), 1.87 (m, 1H), 2.28 (m, 1H), 2.77-2.84 (dt, J = 2.5,3.0 Hz, 1H), 3.0 (brs. 1H), 3.67 (d, J = 11.0 Hz, 1H), 3.87 (brs, 1H), 12.2 (s, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2118 - 2122
[2] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00604
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1719 - 1728
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 966 - 973
[5] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
1-Boc-3-piperidinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-3-piperidinecarboxylic acid Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 1-Boc-3-piperidinecarboxylic acid manufacturers
- Product
- 1-(tert-Butoxycarbonyl)nipecotic Acid 84358-12-3
- Price
- US $25.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 500tons
- Release date
- 2023-10-12
- Product
- 1-(tert-Butoxycarbonyl)nipecotic Acid 84358-12-3
- Price
- US $50.00-40.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000/month
- Release date
- 2023-10-12
- Product
- 1-Boc-3-piperidinecarboxylic acid 84358-12-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2020-07-16