BP 897
- Product Name
- BP 897
- CAS No.
- 314776-92-6
- Chemical Name
- BP 897
- Synonyms
- BP897/BP-897;BP 897 (hydrochloride);BP897 >98% (HPLC), solid;N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide;N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride;N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride;Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897
- CBNumber
- CB7503212
- Molecular Formula
- C26H31N3O2
- Formula Weight
- 417.55
- MOL File
- 314776-92-6.mol
BP 897 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 10 mg/mL, soluble
- form
- solid
- color
- off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B9308
- Product name
- BP897
- Purity
- >98% (HPLC), solid
- Packaging
- 5mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 25831
- Product name
- BP-897
- Packaging
- 1mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 25831
- Product name
- BP-897
- Packaging
- 25mg
- Price
- $246
- Updated
- 2024/03/01
- Product number
- 25831
- Product name
- BP-897
- Packaging
- 5mg
- Price
- $88
- Updated
- 2024/03/01
- Product number
- 25831
- Product name
- BP-897
- Packaging
- 10mg
- Price
- $132
- Updated
- 2024/03/01
BP 897 Chemical Properties,Usage,Production
Description
BP-897 is a dopamine D3 receptor partial agonist. It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α1- and α2-adrenergic receptors (Kis = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT7 (Kis = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (Kis = >1 μM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC50 = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D3 receptor antagonist nafadotride. It also acts as a dopamine D3 receptor antagonist, failing to increase [35S]GTPγS binding to CHO cell membranes expressing the recombinant human D3 receptor and inhibiting the effect of dopamine in the same assay (IC50 = 416.87 nM). BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine.
Biochem/physiol Actions
Partially selective D3 dopamine receptor agonist.