Ibipinabant
- Product Name
- Ibipinabant
- CAS No.
- 464213-10-3
- Chemical Name
- Ibipinabant
- Synonyms
- SLV319;BMS 646256;ibipinabant;(S)-SLV 319;Ibipinabant/SLV319/BMS-646256;Ibipinabant Impurity 1 ((S)-SLV 319);(4S)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide;(4S)-3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide;1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4S)-
- CBNumber
- CB7504769
- Molecular Formula
- C23H20Cl2N4O2S
- Formula Weight
- 487.4
- MOL File
- 464213-10-3.mol
Ibipinabant Property
- Density
- 1.38
- storage temp.
- Store at -20°C
- solubility
- ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
- form
- crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 10009022
- Product name
- (S)-SLV 319
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 10009022
- Product name
- (S)-SLV 319
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $317
- Updated
- 2024/03/01
- Product number
- 10009022
- Product name
- (S)-SLV 319
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $475
- Updated
- 2024/03/01
- Product number
- S560015
- Product name
- (S)-SLV319
- Packaging
- 5mg
- Price
- $875
- Updated
- 2021/12/16
- Product number
- S560015
- Product name
- (S)-SLV319
- Packaging
- 10mg
- Price
- $1500
- Updated
- 2021/12/16
Ibipinabant Chemical Properties,Usage,Production
Uses
(S)-SLV 319 is a potent, selective CB1 receptor antagonist.
Biological Activity
ki: 7.8 and 7,9 nm for cb1 and peripheral cannabinoid (cb2), respectively(s)-slv 319 is a cb1 receptor antagonist.it has been reported that central cannabinoid (cb1) receptor antagonists may have potential in the treatment of a variety of diseases including cognitive disorders, neuro-inflammatory disorders, obesity, septic shock, psychosis, addiction, as well as gastrointestinal disorders.
in vitro
previous study found that (s)-slv 319 was a potent and selective cb1 receptor antagonist with ki values of 7.8 and 7,9 nm for cb1 and cb2, respectively. in addition, (s)-slv 319 was found to be less lipophilic and thus more water soluble than other previously identified ligands of cb1 receptor [1].
in vivo
previous animal study showed that in rats exposed to an ambient temperature of 22°c, a moderate dose of lps at 25 - 100 μg/kg could induce a fall in body temperature. such response was not affected by desensitization of intra-abdominal trpv1 receptors with resiniferatoxin at 20 μg/kg, by systemic trpv1 antagonism with capsazepine at 40 mg/kg, or by systemic cb2 receptor antagonism with sr144528 at 1.4 mg/kg. in contrast, cb1 receptor antagonism by slv319 at 15 mg/kg or rimonabant at 4.6 mg/kg was able to block lps caused hypothermia [2].
References
[1] j. h. m. lange, h. h. van stuivenberg, w. veerman, et al. novel 3,4-diarylpyrazolines as potent cannabinoid cb1 receptor antagonists with lower lipophilicity. bioorganic & medicinal chemistry letters 15, 4794-4798 (2005).
[2] steiner aa et al. the hypothermic response to bacterial lipopolysaccharide critically depends on brain cb1, but not cb2 or trpv1, receptors. j physiol. 2011 may 1;589(pt 9):2415-31.
Ibipinabant Preparation Products And Raw materials
Raw materials
Preparation Products
Ibipinabant Suppliers
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 14055
- Advantage
- 65
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 18201884268
- magean83@163.com
- Country
- China
- ProdList
- 1548
- Advantage
- 58
- Tel
- 15050866711
- Fax
- QQ:2677337387
- contact@zintellec.com
- Country
- China
- ProdList
- 421
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49374
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8617
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44458
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58