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Ibipinabant

Product Name
Ibipinabant
CAS No.
464213-10-3
Chemical Name
Ibipinabant
Synonyms
SLV319;BMS 646256;ibipinabant;(S)-SLV 319;Ibipinabant Impurity 1 ((S)-SLV 319);(4S)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide;(4S)-3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide;1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4S)-
CBNumber
CB7504769
Molecular Formula
C23H20Cl2N4O2S
Formula Weight
487.4
MOL File
464213-10-3.mol
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Ibipinabant Property

Density 
1.38
storage temp. 
Store at -20°C
solubility 
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
crystalline solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009022
Product name
(S)-SLV 319
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
10009022
Product name
(S)-SLV 319
Purity
≥98%
Packaging
5mg
Price
$317
Updated
2024/03/01
Cayman Chemical
Product number
10009022
Product name
(S)-SLV 319
Purity
≥98%
Packaging
10mg
Price
$475
Updated
2024/03/01
TRC
Product number
S560015
Product name
(S)-SLV319
Packaging
5mg
Price
$875
Updated
2021/12/16
TRC
Product number
S560015
Product name
(S)-SLV319
Packaging
10mg
Price
$1500
Updated
2021/12/16
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Ibipinabant Chemical Properties,Usage,Production

Uses

(S)-SLV 319 is a potent, selective CB1 receptor antagonist.

Biological Activity

ki: 7.8 and 7,9 nm for cb1 and peripheral cannabinoid (cb2), respectively(s)-slv 319 is a cb1 receptor antagonist.it has been reported that central cannabinoid (cb1) receptor antagonists may have potential in the treatment of a variety of diseases including cognitive disorders, neuro-inflammatory disorders, obesity, septic shock, psychosis, addiction, as well as gastrointestinal disorders.

in vitro

previous study found that (s)-slv 319 was a potent and selective cb1 receptor antagonist with ki values of 7.8 and 7,9 nm for cb1 and cb2, respectively. in addition, (s)-slv 319 was found to be less lipophilic and thus more water soluble than other previously identified ligands of cb1 receptor [1].

in vivo

previous animal study showed that in rats exposed to an ambient temperature of 22°c, a moderate dose of lps at 25 - 100 μg/kg could induce a fall in body temperature. such response was not affected by desensitization of intra-abdominal trpv1 receptors with resiniferatoxin at 20 μg/kg, by systemic trpv1 antagonism with capsazepine at 40 mg/kg, or by systemic cb2 receptor antagonism with sr144528 at 1.4 mg/kg. in contrast, cb1 receptor antagonism by slv319 at 15 mg/kg or rimonabant at 4.6 mg/kg was able to block lps caused hypothermia [2].

References

[1] j. h. m. lange, h. h. van stuivenberg, w. veerman, et al. novel 3,4-diarylpyrazolines as potent cannabinoid cb1 receptor antagonists with lower lipophilicity. bioorganic & medicinal chemistry letters 15, 4794-4798 (2005).
[2] steiner aa et al. the hypothermic response to bacterial lipopolysaccharide critically depends on brain cb1, but not cb2 or trpv1, receptors. j physiol. 2011 may 1;589(pt 9):2415-31.

Ibipinabant Preparation Products And Raw materials

Raw materials

Preparation Products

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Ibipinabant Suppliers

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464213-10-3, IbipinabantRelated Search:

Thiophanate-methyl Itopride 2-Phenylphenol Kresoxim-methyl Sulfuryl chloride Triphenylphosphine Methyl acrylate Itopride hydrochloride Bensulfuron methyl Triphenylmethyl Chloride Methylparaben Methyl Methyl bromide Parathion-methyl Phenylacetone 3-(4-CHLOROPHENYL)-4-PHENYL-1H PYRAZOLE Ibipinabant

  • SLV319
  • ibipinabant
  • (4S)-3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide
  • (S)-SLV 319
  • BMS 646256
  • (4S)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
  • 1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4S)-
  • Ibipinabant Impurity 1 ((S)-SLV 319)
  • 464213-10-3
  • 1