VENTURICIDIN A

Product Name: VENTURICIDIN A
CAS No.: 33538-71-5
Chemical Name: VENTURICIDIN A
Synonyms: a-130;aa-0368;venturicidinb,3’-carbamate;HHQKNFDAEDTRJK-WLJINWSWSA-N;4,21-Dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)-
CBNumber: CB7505296
Molecular Formula: C41H67NO11
Formula Weight: 749.97
MOL File: 33538-71-5.mol

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VENTURICIDIN A Property

Melting point:: 145-147°; mp 140-142°
alpha: D +119° (c = 0.5 in chloroform)
Boiling point:: 874.9±65.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
pka: 11.80±0.70(Predicted)
form: White to off-white solid.
color: White to off-white

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Safety

RTECS: YX4556000
HS Code: 2941900000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15377
Product name: Venturicidin A
Purity: ≥95%
Packaging: 1mg
Price: $125
Updated: 2024/03/01

Cayman Chemical

Product number: 15377
Product name: Venturicidin A
Purity: ≥95%
Packaging: 5mg
Price: $500
Updated: 2024/03/01

TRC

Product number: V121003
Product name: VenturicidinA
Packaging: 1mg
Price: $635
Updated: 2021/12/16

Adipogen Life Sciences

Product number: BVT-0454-M001
Product name: VenturicidinA
Purity: ≥98%(1H-NMR,HPLC)
Packaging: 1mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: C4641
Product name: VenturicidinA
Packaging: 1mg
Price: $249
Updated: 2021/12/16

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VENTURICIDIN A Chemical Properties,Usage,Production

Description

Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces. It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants. Venturicidin A is also cytotoxic against trypanosomes (IC₅₀ = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells. It inhibits bacterial and mitochondrial ATP synthases.

Uses

The macrolide antibiotic, Venturicidin A, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent.

Uses

Venturicidin A is an antibiotic and potent inhibitor of mitochondrial ATP synthase.

Definition

ChEBI: Venturicidin a is a diterpene lactone.

IC 50

Aminoglycoside

References

[1] A. RHODES. Venturicidin: A New Antifungal Antibiotic of Potential Use in Agriculture[J]. Nature, 1961, 192 4806: 952-954. DOI: 10.1038/192952a0
[2] DAVID S. PERLIN Alan E S Lisa R Latchney. Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin[J]. Biochimica et Biophysica Acta-Bioenergetics, 1985, 807 3: Pages 238-244. DOI: 10.1016/0005-2728(85)90254-3
[3] A MATSUNO-YAGI Y H. Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds.[J]. The Journal of Biological Chemistry, 1993, 268 9: 6168-6173.

VENTURICIDIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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VENTURICIDIN A Suppliers

China 19 India 1 Switzerland 1 United Kingdom 2 United States 5 Global 28

Shanghai EFE Biological Technology Co., Ltd.

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Lynnchem

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Novachemistry

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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MedBioPharmaceutical Technology Inc

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Energy Chemical

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33538-71-5, VENTURICIDIN ARelated Search:

Venturicidin Methyl (S)-(+)-3-hydroxybutyrate Isobutyl butyrate 1,4-Pentadien-3-ol 2-METHYL-1-PENTEN-3-OL TRANS-5-DECEN-1-OL n-Butyl carbamate 4-METHYL-4-HEPTEN-3-OL 2-HEXEN-4-OL (+)-METHYL (S)-3-HYDROXYPENTANOATE N-PROPYLCARBAMATE 2-OCTEN-4-OL Ethyl (S)-3-hydroxybutyrate Methyl (R)-(-)-3-hydroxybutyrate TRANS-2-DODECEN-1-OL 2-HEPTEN-4-OL TRANS-2-UNDECEN-1-OL 2-(ALLYLOXY)TETRAHYDROPYRAN

a-130

aa-0368

venturicidinb,3’-carbamate

HHQKNFDAEDTRJK-WLJINWSWSA-N

4,21-Dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)-

33538-71-5

C41H67NO11

Antibiotic