ChemicalBook > CAS DataBase List > XCT 790

XCT 790

Product Name
XCT 790
CAS No.
725247-18-7
Chemical Name
XCT 790
Synonyms
CS-1881;XCT 790; XCT-790;XCT 790,Inhibitor,Estrogen Receptor/ERR,Autophagy,XCT790,inhibit,XCT-790;3-[4-(2,4-bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-n-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide;2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-;(E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide;3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide XCT 790;XCT 790 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide
CBNumber
CB7505302
Molecular Formula
C23H13F9N4O3S
Formula Weight
596.42
MOL File
725247-18-7.mol
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XCT 790 Property

storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
solid
color 
yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
X4753
Product name
XCT790
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
X4753
Product name
XCT790
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$513.6
Updated
2024/03/01
Cayman Chemical
Product number
16035
Product name
XCT790
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
16035
Product name
XCT790
Purity
≥98%
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
16035
Product name
XCT790
Purity
≥98%
Packaging
10mg
Price
$213
Updated
2024/03/01
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XCT 790 Chemical Properties,Usage,Production

Description

XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM). It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 μM. XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B. XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant .

Uses

XCT790 is a potent inverse agonist of ERRα.

Definition

ChEBI: XCT 790 is a member of cinnamamides.

Biochem/physiol Actions

XCT 790 is a 5′adenosine monophosphate-activated protein kinase (AMPK) activator. It also acts as a proton ionophore and an uncoupler of oxidative phosphorylation in mitochondria. XCT790 impairs vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang-2) expression and exhibits suppression of endometrial tumor via estrogen-related receptor (ERRα) inhibition. XCT790 mediates cell cycle arrest and favors apoptosis in triple-negative breast cancer (TNBC).

storage

Store at +4°C

References

[1] lu x, peng l, lv m, ding k. recent advance in the design of small molecular modulators of estrogen-related receptors. curr pharm des. 2012;18(23):3421-31.
[2] wu f, wang j, wang y, kwok tt, kong sk, wong c. estrogen-related receptor alpha (erralpha) inverse agonist xct-790 induces cell death in chemotherapeutic resistant cancer cells. chem biol interact. 2009 oct 7;181(2):236-42.

XCT 790 Preparation Products And Raw materials

Raw materials

Preparation Products

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XCT 790 Suppliers

China 55 India 1 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 10 Global 71
Yangzhou Siyu Chemical Co.,Ltd.
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Haoyuan Chemexpress Co., Ltd.
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AdooQ Bioscience CHINA
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SPIRO PHARMA
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Pharmacodia (Beijing) Co.,Ltd
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Heze Development Zone chuangli Chemical Co., Ltd.
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Amatek Scientific Co. Ltd.
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Angel Pharmatech, Ltd.
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Shanghai Jizhi Biochemical Technology Co. Ltd.
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Fan De(Beijing) Biotechnology Co., Ltd.
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DC Chemicals
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career henan chemical co
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Absin Bioscience Inc.
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Nanjing Tengyi Biotechnology Co., Ltd
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View Lastest Price from XCT 790 manufacturers

Career Henan Chemical Co
Product
XCT 790 725247-18-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
100KG
Release date
2020-02-04

725247-18-7, XCT 790Related Search:

4-(Trifluoromethyl)benzene-1-sulfonyl chloride xav-939 XANTHINE AMINE CONGENER XD14

  • XCT 790; XCT-790
  • CS-1881
  • 3-[4-(2,4-bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-n-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide
  • 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide XCT 790
  • XCT 790 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide
  • (E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
  • 2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-
  • XCT 790,Inhibitor,Estrogen Receptor/ERR,Autophagy,XCT790,inhibit,XCT-790
  • 725247-18-7
  • C23H13F9N4O3S