7-Hydroxy-1,2,3,4-tetrahydroquinoline
- Product Name
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline
- CAS No.
- 58196-33-1
- Chemical Name
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline
- Synonyms
- Venadaparib Impurity 56;1,2,3,4-Tetrahydro-7-quinolinol;1,2,3,4-Tetrahydro-quinolin-7-ol;7-Quinolinol, 1,2,3,4-tetrahydro-;7-Hydroxy-1,2,3,4-tetrahydroquinoL;7-hydroxy-1,2,3,4-Tetrahydro-quinolin;7-Hydroxy-1,2,3,4-tetrahydroquinoline;7-Hydroxy-1,2,3,4-tetrahydroquinoline1;7-Hydroxy-1,2,3,4-Tetrahydro Quinolinoe;7-Hydroxy-1,2,3,4-tetrahydroquinoline ISO 9001：2015 REACH
- CBNumber
- CB7511736
- Molecular Formula
- C9H11NO
- Formula Weight
- 149.19
- MOL File
- 58196-33-1.mol
7-Hydroxy-1,2,3,4-tetrahydroquinoline Property
- Melting point:
- 70-80 °C
- Boiling point:
- 319.7±31.0 °C(Predicted)
- Density
- 1.141±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 10.70±0.20(Predicted)
- form
- Solid
- color
- Dark Orange to Very Dark Orange
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C9H11NO/c11-8-4-3-7-2-1-5-10-9(7)6-8/h3-4,6,10-11H,1-2,5H2
- InChIKey
- HJJRGZMJZDSMDB-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(O)=C2)CCC1
- CAS DataBase Reference
- 58196-33-1(CAS DataBase Reference)
- EPA Substance Registry System
- 7-Quinolinol, 1,2,3,4-tetrahydro- (58196-33-1)
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H957860
- Product name
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR952616
- Product name
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 072901
- Product name
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- OR952616
- Product name
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 5g
- Price
- $148
- Updated
- 2021/12/16
- Product number
- 072901
- Product name
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $188
- Updated
- 2021/12/16
7-Hydroxy-1,2,3,4-tetrahydroquinoline Chemical Properties,Usage,Production
Synthesis
22246-18-0
58196-33-1
The general procedure for the synthesis of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 3,4-dihydro-7-hydroxy-2(1H)-quinolinone was as follows: 7-hydroxy-3,4-dihydroquinolin-2(1H)-one (2.00 g, 12.26 mmol) was dissolved in tetrahydrofuran (THF, 20 mL) and the solution was cooled down to 0 °C. Subsequently, sodium borohydride (NaBH4, 1.07 g, 28.19 mmol) was added, and then iodine (I2, 3.42 g, 13.48 mmol) dissolved in THF (20 mL) was slowly added dropwise through the addition funnel to the reaction mixture. After installing the condenser, the reaction mixture was refluxed overnight. After completion of the reaction, the reaction mixture was neutralized with 3 M hydrochloric acid solution and then extracted three times with dichloromethane. The organic layers were combined and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a viscous yellow oil. Finally, the crude product was purified by fast column chromatography to afford 7-hydroxy-1,2,3,4-tetrahydroquinoline as a white crystalline solid (1.80 g, 98% yield).
References
[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 2, p. 650 - 654
[2] Angew. Chem., 2013, vol. 125, # 2, p. 678 - 682,5
[3] Chinese Chemical Letters, 2018, vol. 29, # 10, p. 1497 - 1499
[4] Organic Letters, 2011, vol. 13, # 23, p. 6196 - 6199
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 24, p. 3954 - 3962
7-Hydroxy-1,2,3,4-tetrahydroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Hydroxy-1,2,3,4-tetrahydroquinoline manufacturers
- Product
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline 58196-33-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline 58196-33-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 7-Hydroxy-1,2,3,4-tetrahydroquinoline 58196-33-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-08