MAPKAPK2 antibody

Source Reactivity Background References

Product Name: MAPKAPK2 antibody
Chemical Name: MAPKAPK2 antibody
Synonyms: MAPKAPK2 antibody
CBNumber: CB75653004
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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MAPKAPK2 antibody Chemical Properties,Usage,Production

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

In response to cytokines, stress, and chemotactic factors, MAP kinase-activated protein kinase 2 is rapidly phosphorylated and activated. It has been shown that MAPKAPK-2 is a direct target of p38 MAPK. Multiple residues of MAPKAPK-2 are phosphorylated in vivo in response to stress. However, only four residues are phosphorylated by p38 MAPK in an in vitro kinase assay. Phosphorylation at Thr222, Ser272, and Thr334 appears to be essential for the activity of MAPKAPK-2. Thr25 is phosphorylated by p42 MAPK in vitro, but is not required for the activation of MAPKAPK-2.

References

[1] Rouse, J. et al. (1994) Cell 78, 1027-1037.
[2] Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.

MAPKAPK2 antibody Preparation Products And Raw materials

Raw materials

Preparation Products

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MAPKAPK2 antibody Suppliers

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MAPKAPK2 antibody