HCV NS5a
Description Source Background- Product Name
- HCV NS5a
- Chemical Name
- HCV NS5a
- Synonyms
- HCV NS5a
- CBNumber
- CB75733335
- Formula Weight
- 0
- MOL File
- Mol file
HCV NS5a Chemical Properties,Usage,Production
Description
Recombinant HCV NS5A produced in E. coli is a single polypeptide chain containing 118 amino acids (aa 2210-2306) and having a molecular mass of 13.4kDa.
Recombinant HCV NS5A is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
NS5A is a component of the replication complex which takes part in RNA-binding. NS5A protein’s hyperphosphorylated form is an inhibitor of viral replication. NS5A interacts with Human VAPB and through it targets the viral replication complex to vesicles. NS5A down-regulates viral IRES translation initiation and mediates interferon resistance by interacting and inhibiting human EIF2AK2/PKR. NS5a is also inhibits apoptosis by interacting with BIN1 and FKBP8.
HCV NS5a Preparation Products And Raw materials
Raw materials
Preparation Products
HCV NS5a Suppliers
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