ChemicalBook > CAS DataBase List > AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE

Product Name
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE
CAS No.
167114-91-2
Chemical Name
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE
Synonyms
ALP;LYS-LYS-ALA-LEU-ARG-ARG-GLN-GLU-ALA-VAL-ASP-ALA-LEU;ILC;CCL27;ESKINE;Alk Phos;FLJ10774;Skinkine;CTACK HUMAN;DKFZp434C116
CBNumber
CB7671283
Molecular Formula
C64H116N22O19
Formula Weight
1497.74
MOL File
167114-91-2.mol
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AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Property

storage temp. 
-20°C
solubility 
H2O: soluble
form 
lyophilized powder
color 
white
biological source
synthetic
Water Solubility 
Soluble to 1 mg/ml in water
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Safety

Hazard Codes 
Xn,F
Risk Statements 
20/21/22-36-11
Safety Statements 
22-24/25-26-36/37-16
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB3701239
Product name
Anti-Human IgG F(ab′)2, F(ab′)2 fragment, highly cross absorbed-Alkaline Phosphatase antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
500μg
Price
$306
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB3700469
Product name
Anti-HAMSTER IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
500μg
Price
$276
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB3700461
Product name
Anti-Hamster IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
500μl
Price
$309
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB3700401
Product name
Anti-Guinea Pig IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
500μg
Price
$276
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB3700053
Product name
Anti-Cat IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
1mg
Price
$277
Updated
2024/03/01
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AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Chemical Properties,Usage,Production

Uses

Autocamtide 2-related inhibitory peptide has been used:

  • To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
  • To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
  • To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII

Uses

Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII.

Biological Activity

synthetic peptide aip (autocamtide-2-related inhibitory peptide) is a nonphosphorylatable analog of autocamtide-2, which was identified to be a highly specific and potent inhibitor of calmodulin-dependent protein kinase ii (cam-kinase ii, camkii). camkii is a serine/threonine-specific protein kinase, which is modulated by the ca2+/calmodulin.

Biochem/physiol Actions

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.

in vitro

aip (1 mm) completely inhibited camkii activity, but did not affect camp-dependent protein kinase, calmodulin-dependent protein kinase iv and protein kinase c,. the inhibition was noncompetitive, and the action was caused by binding to the autophosphorylation site, which is distinc from that for the exogenous substrate. the ic50 for the autophosphorylation of cam ii is 100 nm [1].

in vivo

mice treated with aip by transgenic expression of aip, were protected from fructose-rich diet-induced arrhythmogenesis, spontaneous contractions and spontaneous ca2+ release events [2]. intra-nucleus accumbens (nac) injection of aip could dose-dependently increase the hwl (hindpaw withdrawal latency) to noxious thermal and mechanical stimulation in rats with mononeuropathy [3].

IC 50

40 nm for cam-kinase ii [1].

storage

Store at -20°C

References

[1] ishida a1, kameshita i, okuno s, kitani t, fujisawa h. a novel highly specific and potent inhibitor of calmodulin-dependent protein kinase ii. biochem biophys res commun. 1995 jul 26;212(3):806-12.
[2] sommese l, valverde ca, blanco p, castro mc, rueda ov, kaetzel m, dedman j, anderson me, mattiazzi a, palomeque j. ryanodine receptor phosphorylation by camkii promotes spontaneous ca(2+) release events in a rodent model of early stage diabetes: the arrhythmogenic substrate. int j cardiol. 2016 jan 1;202:394-406.
[3] bian h, yu lc. intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase ii inhibitor aip induced antinociception in rats with mononeuropathy. neurosci lett. 2015 jul 10;599:129-32.

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Suppliers

China 94 Germany 3 Switzerland 2 United Kingdom 3 United States 17 Global 119
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View Lastest Price from AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE manufacturers

Hebei Anda Technology Co., LTD
Product
Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt 167114-91-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Ex 20 tons
Release date
2022-10-24
Qiuxian Baitai New Material Co., LTD
Product
alp 167114-91-2
Price
US $470.00/mg
Min. Order
1KG
Purity
98%
Supply Ability
500ton/Month
Release date
2021-12-15
Career Henan Chemical Co
Product
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE 167114-91-2
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

167114-91-2, AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDERelated Search:

H-GLY-GLY-SER-LEU-TYR-SER-PHE-GLY-LEU-NH2 ALLATOSTATIN IV RGDV Z-Ile-Glu-Pro-Phe-OMe ATRIAL NATRIURETIC FACTOR (1-28) (RAT) H-GLY-ASP-GLY-ARG-LEU-TYR-ALA-PHE-GLY-LEU-NH2 ALLATOSTATIN I H-LEU-SER-LYS-LEU-NH2 RIP KN-93 Phosphate AUTOCAMTIDE-2 RELATED INHIBITORY PEPTIDE II, CELL-PERMEABLE AUTOCAMTIDE-2 RELATED INHIBITORY PEPTIDE, MYRISTOYLATED AUTOCAMTIDE-2 RELATED INHIBITORY PEPTIDE II [LYS3, PHE10, TYR13]-AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE (AIP) ANALOG,[LYS3,PHE10,TYR13]-AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE H-VAL-PRO-PRO-OH PEP2M Histatin 5

  • (ALA9)-AUTOCAMTIDE-2
  • ALS9 AUTOCAMTIDE 2
  • ALP
  • Anti-Rabbit IgG (H+L)-Alkaline Phosphatase antibody produced in donkey
  • Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in chicken
  • Anti-Mouse IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat
  • Anti-Mouse IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey
  • Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Mouse IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in sheep
  • Anti-Mouse IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
  • Alk Phos
  • Anti-Bovine IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
  • Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Chicken IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Chicken IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat
  • Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
  • Anti-Dog IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Dog IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Dog IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
  • Anti-Cat IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat
  • Anti-Cat IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
  • Anti-Bovine IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Ferret IgG (γ-chain specific)-Alkaline Phosphatase antibody produced in goat
  • Anti-Ferret IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat
  • Anti-Sheep IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Sheep IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey
  • Anti-Sheep IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat
  • Anti-Rat IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey
  • Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in donkey
  • Anti-Rat IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat
  • Anti-Sheep IgG (Fc specific), highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Rat IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Rat IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in sheep
  • Anti-Hamster IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
  • Anti-HAMSTER IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
  • Anti-HAMSTER IgG (H+L)-Alkaline Phosphatase antibody produced in goat
  • Anti-Hamster IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat
  • Anti-Pig IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Porcine IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Swine IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Guinea Pig IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in goat
  • Anti-Guinea Pig IgG (H+L)-Alkaline Phosphatase antibody produced in goat
  • Anti-Guinea Pig IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Guinea Pig IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat
  • Anti-Guinea Pig IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat
  • Anti-Goat IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey
  • Anti-goat IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Goat IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Chicken IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat
  • Anti-Horse IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Horse IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Horse IgG (H+L)-Alkaline Phosphatase antibody produced in goat
  • Anti-Cat IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit
  • Anti-Cat IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit