ChemicalBook > CAS DataBase List > Ginkgolic acid

Ginkgolic acid

Product Name: Ginkgolic acid
CAS No.: 22910-60-7
Chemical Name: Ginkgolic acid
Synonyms: C-17:1;C10794;Ginkgolic;Ginkgolicaci;Ginkgoic acid;C15:1)Ginkgol;GINKGOLIC ACID;ROMANICARDIC ACID;Phenolic acid C15:1;(15:1)-Anacardic acid
CBNumber: CB7673186
Molecular Formula: C22H34O3
Formula Weight: 346.5
MOL File: 22910-60-7.mol

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Ginkgolic acid Property

Melting point:: 45～48℃
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
Boiling point:: 221-223 °C(Press: 4 Torr)
Density: 0.9148 g/cm3
pka: 3.08±0.30(Predicted)
form: White solid
color: White to Off-White
InChI: InChI=1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChIKey: YXHVCZZLWZYHSA-FPLPWBNLSA-N
SMILES: C(O)(=O)C1=C(CCCCCCC/C=C\CCCCCC)C=CC=C1O
LogP: 9.269 (est)
CAS DataBase Reference: 22910-60-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-26
WGK Germany: 3
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89522
Product name: Ginkgolic acid C15:1
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 10 mg
Price: $508
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.08197
Product name: InSolution Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem
Packaging: 2mg
Price: $196
Updated: 2025/07/31

Sigma-Aldrich

Product number: 345887
Product name: Ginkgolic Acid (15:1)
Packaging: 5mg
Price: $429
Updated: 2025/07/31

Sigma-Aldrich

Product number: 02580585
Product name: Ginkgolic acid C15:1
Purity: primary reference standard
Packaging: 10mg
Price: $1100
Updated: 2025/07/31

Cayman Chemical

Product number: 18422
Product name: Ginkgolic Acid C15:1
Purity: ≥95%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

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Ginkgolic acid Chemical Properties,Usage,Production

Description

Ginkgolic acid is slightly toxic and is an allergen; for this reason, some sources suggest using only the standardized extract, which is standardized to the flavonoids and minimizes ginkgolic acid content.
Ginkgolic acid is active against the tubercle bacillus. Elsewhere, leaf extracts are used in peripheral arterial circulation problems like arteriosclerotic angiopathy, post-thrombotic syndrome, diabetic vasoconstriction with gangrene and angina, intermittent claudication，Raynaud's disease. Extracts are inhaled for ear, nose, and throat ailments like bronchitis and chronic rhinitis.
Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia. However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts. Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position. It inhibits SUMOylation in vitro (IC50 = 3 μM) and in cells without affecting protein ubiquitination. Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate. Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice.

Uses

Ginkgolic acid C15:1 may be used as a reference standard in the quantitative determination of alkylphenols like ginkgolic acids in Ginkgolic extract using high performance liquid chromatography coupled with mass spectrometry(HPLC-MS).
Ginkgolic acid C15:1 may be used as an analytical reference standard for the quantification of the analyte in Ginkgo biloba plant extracts, and dietary supplements using chromatography techniques.

Definition

ChEBI:Ginkgoic acid is a hydroxybenzoic acid. It derives from a salicylic acid.

General Description

Ginkgolic acid C15:1 is an alkylphenol belonging to the class of ginkgolic acids isolated from Ginkgo biloba leaves. It also shows strong allergenic properties, with carcinogenic and mutagenic activity.

Biochem/physiol Actions

Cell permeable: yes

References

[1] X HE. High-performance liquid chromatography-electrospray ionization-mass spectrometry study of ginkgolic acid in the leaves and fruits of the ginkgo tree (Ginkgo biloba).[J]. Journal of chromatographic science, 2000, 38 4: 169-173. DOI: 10.1093/chromsci/38.4.169
[2] ISAO FUKUDA. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.[J]. Chemistry & biology, 2009, 16 2: 133-140. DOI: 10.1016/j.chembiol.2009.01.009
[3] HONG-BIN LUO. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014: 16586-16591. DOI: 10.1073/pnas.1417548111
[4] JIGUANG MA. Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis.[J]. Oncotarget, 2015: 20993-21003. DOI: 10.18632/oncotarget.3663

Ginkgolic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ginkgolic acid manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Ginkgolic Acid 22910-60-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-27

Guangzhou Biocar Biotechnology Co.,Ltd.

Product: Ginkgolic acid 22910-60-7
Price: US $8.80-7.90/kg
Min. Order: 1kg
Purity: 99.99%HPLC;USP42
Supply Ability: 1000kg
Release date: 2022-11-16

Xingtai Haoxun Import and Export Trade Co., Ltd.

Product: Ginkgolic acid 4554-49-0
Price: US $1.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 500kg
Release date: 2020-11-06

22910-60-7, Ginkgolic acidRelated Search:

allyltrimethylammonium chloride Folic acid Stearic acid 4-Methylsalicylic acid Sodium sulfosalicylate Salicylic acid Starch Sodiilm octenylsuccinate 5-Sulfosalicylic acid dihydrate Ethyl 2-(Chlorosulfonyl)acetate Ginkgolic Acid C17:1,6-[(10Z)-Heptadecenyl]salicylic acid, Ginkgolic acid II GINKGETIN 6-pentadecylsalicylic acid Ginkgolic Acid C17:2 Ginkgolide J Ginkgolic acid (13:0) DODECENYLSUCCINIC ACID Citric acid Ginkgolide A

C-17:1

GINKGOLIC ACID

ROMANICARDIC ACID

Ginkgolic

C10794

6-[(8Z)-Pentadecenyl]-salicylic acid, Ginkgolic acid I

2-Hydroxy-6-[(8Z)-8-pentadecenyl]benzoic acid

2-Hydroxy-6-[(Z)-8-pentadecenyl]benzoic acid

Anacardic acid monoene

Phenolic acid C15:1

(15:1)-Anacardic acid

Ginkgoic acid

6-[(8Z)-Pentadecenyl]-salicylic acid

2-Hydroxy-6-(pentadec-8-en-1-yl)benzoic acid

C15:1)Ginkgol

GINKGOLIC ACID;GINKGOLIC ACID I;ROMANICARDIC ACID

(Z)-2-hydroxy-6-(pentadec-8-en-1-yl)benzoic acid

Ginkgolic Acid 15:1 〔Anacardic Acid 15:1, Ginkgolic Acid, Ginkgolic Acid Ⅰ〕

Ginkgolic acid, 98%, from Ginkgo biloba L.

Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem

InSolution Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem

Benzoic acid, 2-hydroxy-6-(8Z)-8-pentadecen-1-yl-

Ginkgolicaci

Ginkgolic acid USP/EP/BP

Ginkgolic Acid,E3 ligating enzyme,Ubiquitin activating enzyme,Ubiquitin conjugating enzyme,E2 conjugating enzyme,E1/E2/E3 Enzyme,Inhibitor,E1 activating enzyme,inhibit,Ubiquitin ligase

Ginkgolic acid C15:1-RM

Ginkgolic acid, Naturally occurring compound

Ginkgolic Acid, 10 mM in DMSO

22910-60-7

4554-49-0

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