1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE

Product Name: 1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE
CAS No.: 179557-01-8
Chemical Name: 1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE
Synonyms: 1-BOC-4-CYCLOPROPYLAMINO-PIPERIDINE;1-N-BOC 4-(CYCLOPROPYLAMINO) PIPERIDINE;4-(Cyclopropylamino)piperidine, N1-BOC protected;4-(Cyclopropylamino)piperidine,N1-BOCprotected97%;4-(Cyclopropylamino)piperidine, N1-BOC protected 97%;1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE;4-(Cyclopropylamino)piperidine, N1-BOC protected 95+%;TERT-BUTYL 4-(CYCLOPROPYLAMINO)PIPERIDINE-1-CARBOXYLATE;4-Cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(cyclopropylamino)-, 1,1-dimethylethyl ester
CBNumber: CB7685491
Molecular Formula: C13H24N2O2
Formula Weight: 240.34
MOL File: 179557-01-8.mol

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1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE Property

Boiling point:: 329.7±35.0 °C(Predicted)
Density: 1.06±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 8.89±0.20(Predicted)
form: oil
color: Clear colourless

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T135543
Product name: 1-tert-Butoxycarbonyl-4-(cyclopropylamino)piperidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 265692
Product name: 1-Boc-4-cyclopropylaminopiperidine
Packaging: 500mg
Price: $333
Updated: 2021/12/16

AK Scientific

Product number: 9418AA
Product name: 1-tert-Butoxycarbonyl-4-(cyclopropylamino)piperidine
Packaging: 1g
Price: $139
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50840
Product name: 1-Boc-4-cyclopropylaminopiperidine
Packaging: 1g
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-D4
Product name: 4-(Cyclopropylamino)piperidine, N1-Boc protected
Purity: 97%
Packaging: 5G
Price: $256
Updated: 2021/12/16

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1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE Chemical Properties,Usage,Production

Synthesis

79099-07-3

765-30-0

179557-01-8

A methanol (40 mL) solution of tert-butyl 4-oxopiperidine-1-carboxylate (5.0 g, 25.1 mmol) was added to the reaction flask, followed by cyclopropylamine (1.4 g, 25.1 mmol), triethylamine (10.0 mL, 75.3 mmol) and zinc chloride (0.3 g, 2.5 mmol). The reaction mixture was stirred at 60 °C for 7 h. Then sodium cyanoborohydride (4.8 g, 75.3 mmol) was added in batches. The reaction mixture was continued to be stirred at 25 °C for 17 hours. Upon completion of the reaction, the solvent was removed under vacuum and the residue was partitioned between water (250 mL) and ethyl acetate (200 mL). The aqueous layer was further extracted with ethyl acetate (2 x 200 mL) and the organic layers were combined, dried over sodium sulfate and concentrated under vacuum. The residue was purified by column chromatography (basic activated alumina, eluent: 10% to 30% hexane solution of ethyl acetate) to afford the target product tert-butyl 4-(cyclopropylamino)piperidine-1-carboxylate (5.3 g, 88% yield) as a gel. The product data are shown in Table 2.

References

[1] Patent: WO2017/21730, 2017, A1. Location in patent: Page/Page column 46
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 19, p. 3769 - 3789
[3] Patent: WO2010/52255, 2010, A1. Location in patent: Page/Page column 53-54
[4] Patent: WO2007/16610, 2007, A2. Location in patent: Page/Page column 57; 58
[5] Patent: EP3147283, 2017, A1. Location in patent: Paragraph 0106

1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE Suppliers

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179557-01-8, 1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINERelated Search:

1-Boc-4-Methylaminopiperidine 4-CYCLOPROPYLAMINO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER HYDROCHLORIDE 1-Boc-4-Isopropylaminopiperidine 4-Amino-1-Boc-piperidine 1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE 1-Boc-4-Ethylaminopiperidine Isopropyl 4-aminopiperidine-1-carboxylate 1-Boc-4-Propylaminopiperidine

4-(Cyclopropylamino)piperidine, N1-BOC protected 97%

4-(Cyclopropylamino)piperidine, N1-BOC protected

tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(cyclopropylamino)piperidine

4-(Cyclopropylamino)piperidine,N1-BOCprotected97%

4-Cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester

1-Piperidinecarboxylic acid, 4-(cyclopropylamino)-, 1,1-dimethylethyl ester

TERT-BUTYL 4-(CYCLOPROPYLAMINO)PIPERIDINE-1-CARBOXYLATE

1-TERT-BUTOXYCARBONYL-4-(CYCLOPROPYLAMINO)PIPERIDINE

1-N-BOC 4-(CYCLOPROPYLAMINO) PIPERIDINE

1-BOC-4-CYCLOPROPYLAMINO-PIPERIDINE

4-(Cyclopropylamino)piperidine, N1-BOC protected 95+%

179557-01-8