H-D-CHA-OH
- Product Name
- H-D-CHA-OH
- CAS No.
- 58717-02-5
- Chemical Name
- H-D-CHA-OH
- Synonyms
- (R)-2-AMINO-3-CYCLOHEXYLPROPANOIC ACID;H-D-CHA-OH;(R)-2-Amino-3-cycL;D-CYCLOHEXYLALANINE;3-3-CYCLOHEXLALANINE;H-D-CHA-OH USP/EP/BP;H-D-PHE(HEXAHYDRO)-OH;D-3-Cyclohexylalanine;β-Cyclohexyl-D-alanine;3-CYCLOHEXYL-D-ALANINE
- CBNumber
- CB7701438
- Molecular Formula
- C9H17NO2
- Formula Weight
- 171.24
- MOL File
- 58717-02-5.mol
H-D-CHA-OH Property
- Boiling point:
- 307.1±25.0 °C(Predicted)
- Density
- 1.075
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 2.33±0.10(Predicted)
- color
- White to Off-White
- optical activity
- [α]20/D 12±1°, c = 1% in 1 M HCl (dry matter)
- BRN
- 3197315
- InChI
- InChI=1/C9H17NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h7-8H,1-6,10H2,(H,11,12)/t8-/s3
- InChIKey
- ORQXBVXKBGUSBA-MRVPVSSYSA-N
- SMILES
- C1(CCCCC1)C[C@@H](N)C(=O)O |&1:7,r|
- CAS DataBase Reference
- 58717-02-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C986070
- Product name
- (R)-D-Cyclohexylalanine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C986070
- Product name
- (R)-D-Cyclohexylalanine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- AAA0000087
- Product name
- (R)-3-CYCLOHEXYL ALANINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $152.25
- Updated
- 2021/12/16
- Product number
- FC55910
- Product name
- beta-Cyclohexyl-D-alanine
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 126607
- Product name
- (R)-2-Amino-3-cyclohexylpropanoicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
H-D-CHA-OH Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystalline powder
Uses
(R)-2-amino-3-cyclohexylpropanoic acid is an alanine derivative[1].
Application
H-D-CHA-OH is thrombin inhibitor.
Synthesis
701-97-3
27527-05-5
58717-02-5
General procedure for the synthesis of (S)-2-Amino-3-cyclohexylpropionic acid and (R)-2-Amino-3-cyclohexylpropionic acid from 3-cyclohexylpropionic acid: pyridoxamine 4a (2.1 mg, 0.0050 mmol), 4-(naphthalen-1-yl)-2-oxo-butyric acid (1a) (22.8 mg, 0.10 mmol), 2,2-diphenylglycine 11 ( 22.7 mg, 0.10 mmol), CH3COOH (48.0 mg, 0.80 mmol), EtOH (0.40 mL), and H2O (0.10 mL) were stirred for 24 hours at 25 °C. Upon completion of the reaction, the mixture was transferred to a 25 mL aubergine flask and methanol (10 mL) was added to completely dissolve the solid, followed by silica gel (0.50 g). The solvent was removed under reduced pressure at 25 °C. The residue was purified by fast column chromatography (silica gel, eluent ratio EtOH/ethyl acetate/25-28% aqueous ammonia solution = 100:58:16) to afford amino acid 2a (22.0 mg, 96% yield, 83% ee) as a white solid. To determine the enantiomeric excess (ee) of 2a, the amino acid was first converted to the corresponding methyl ester by treatment with diazomethane in methanol at room temperature, and subsequently analyzed by HPLC (Chiralcel OD-H column, mobile phase n-hexane: isopropanol = 85:15, flow rate 1.0 mL/min). The enantiomeric excesses (ee) of the products 2b-1 and 2o, as well as the dr values of the products 2m-n, were determined by converting the amino acids to the corresponding N-benzoyl methyl esters by treatment with thionyl chloride in methanol, then reacting with benzoic anhydride, and finally analyzed by HPLC.
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1036. DOI:10.1080/10408398.2012.708368
H-D-CHA-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from H-D-CHA-OH manufacturers
- Product
- H-D-CHA-OH 58717-02-5
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-08-31
- Product
- H-D-CHA-OH 58717-02-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KSG
- Release date
- 2019-12-20