11BETA-PROSTAGLANDIN E1

Product Name: 11BETA-PROSTAGLANDIN E1
CAS No.: 27415-26-5
Chemical Name: 11BETA-PROSTAGLANDIN E1
Synonyms: 8-epi-PGF2α;(5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid;15-F2t-IsoP;8-Iso-PGF2α;8-ISOPROSTANE;IPF2ALPHA-III;15-F2t-IsoP-d9;8-epi-PGF2α-d9;8-Iso-PGF2α-d9;8-EPI PGF2ALPHA
CBNumber: CB7701867
Molecular Formula: C20H34O5
Formula Weight: 354.48
MOL File: 27415-26-5.mol

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11BETA-PROSTAGLANDIN E1 Property

Boiling point:: 531.0±50.0 °C(Predicted)
Density: 1.153±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: 3 mg/ml
form: A crystalline solid
pka: 4.76±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16350
Product name: 8-iso Prostaglandin F2α
Purity: ≥99%
Packaging: 1mg
Price: $164
Updated: 2024/03/01

Cayman Chemical

Product number: 16350
Product name: 8-iso Prostaglandin F2α
Purity: ≥99%
Packaging: 5mg
Price: $692
Updated: 2024/03/01

Cayman Chemical

Product number: 25903
Product name: 8-iso Prostaglandin F2α MaxSpec® Standard
Packaging: 100μg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 16350
Product name: 8-iso Prostaglandin F2α
Purity: ≥99%
Packaging: 10mg
Price: $1221
Updated: 2024/03/01

TRC

Product number: P838620
Product name: 8-epi-ProstaglandinF2α
Packaging: 10mg
Price: $10725
Updated: 2021/12/16

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11BETA-PROSTAGLANDIN E1 Chemical Properties,Usage,Production

Description

8-iso PGF_2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF_2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF_2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF_2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF_2α inhibits platelet aggregation induced by U-46619 (10⁻⁶ M) and I-BOP (3 x 10⁻⁷ M) with IC₅₀ values of 1.6 x 10⁻⁶ M and 1.8 x 10⁻⁶ M, respectively.

Description

8-iso Prostaglandin F_2α (8-iso PGF_2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF_2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF_2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF_2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF_2α inhibits platelet aggregation induced by U-46619 (10⁻⁶ M) and I-BOP (3 x 10⁻⁷ M) with IC₅₀ values of 1.6 x 10⁻⁶ M and 1.8 x 10⁻⁶ M, respectively.

8-iso Prostaglandin F_2α MaxSpec^® standard is a quantitative grade standard of 8-iso Prostaglandin F_2α that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 8-iso Prostaglandin F_2α MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

(8-epi-prostaglandin F2a) A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

Uses

A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

Definition

ChEBI: A prostanoid that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.

IC 50

Human Endogenous Metabolite

References

[1] JASON D. MORROW L. J R I Thomas M Harris. Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids[J]. Analytical biochemistry, 1990, 184 1: Pages 1-10. DOI: 10.1016/0003-2697(90)90002-q
[2] J.D. MORROW L. J R I T A Minton. The F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist[J]. Prostaglandins, 1992, 44 2: Pages 155-163. DOI: 10.1016/0090-6980(92)90077-7
[3] MICHITAKA KIRIYAMA. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells[J]. British Journal of Pharmacology, 2009, 122 2: 217-224. DOI: 10.1038/sj.bjp.0701367
[4] SAMAR BASU Bengt V Annika Smedman. Conjugated linoleic acid induces lipid peroxidation in humans[J]. FEBS Letters, 2000, 468 1: Pages 33-36. DOI: 10.1016/s0014-5793(00)01193-5

11BETA-PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

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11BETA-PROSTAGLANDIN E1 Suppliers

Canada 1 China 42 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 9 Global 59

J & K SCIENTIFIC LTD.

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Hubei Yangxin Medical Technology Co., Ltd.

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27415-26-5, 11BETA-PROSTAGLANDIN E1Related Search:

Prostaglandin F2a Isoprostane Related Compound 1 8-ISOPROSTANE-D4 2,3-dinor-5,6-dihydro-15-F-isoprostane 8-ISOPROSTANE-D4 [3H]-8-ISOPROSTANE 8,12-iso-isoprostane F2alpha-VI 8,12-iso-isoprostane F2alpha-III

9ALPHA, 11ALPHA15S-TRIHYDROXY-(8BETA)-PROSTA-5Z, 13E-DIEN-1-OIC ACID

8-ISOPROSTANE

8-EPI PROSTAGLANDIN F2ALPHA

8-EPI PGF2ALPHA

8-ISO PROSTAGLANDIN F2ALPHA

(Z)-7-[(1S,2S,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenty

8-Isoprostaglandin F2a

8-ISOPROSTAGLANDIN F2ALPHA, >99%

8-epi-Prostaglandin F2α

8-iso Prostaglandin F2α

(5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid

15(S)-8-Iso-PGF2α

15-F2t-IsoP

15-F2t-Isoprostane

8-epi-PGF2α

8-Iso-PGF2α

Isoprostaglandin F2α type-III

(5Z,8β,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic Acid-d9

15-F2t-IsoP-d9

15-F2t-Isoprostane-d9

7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-Heptenoic Acid-d9

8-epi-PGF2α-d9

8-Iso-PGF2α-d9

8-iso-Prostaglandin F2α-d9

8-Isoprostaglandin F2α-d9

Isoprostaglandin F2α type-III-d9

8-epi-Prostaglandin F<sub>2α</sub>

IPF2ALPHA-III

8-iso Prostaglandin F2α MaxSpec Standard

Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8β,9α,11α,13E,15S)-

8-iso Prostaglandin F2α MaxSpec? Standard

Dinoprost Trometamol EP Impurity C

(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(E)-(3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid ((8S)-PGF2α

Alprostadil Impurity 29

27415-26-5

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