N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

ChemicalBook > CAS DataBase List > N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

Product Name: N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide
CAS No.: 77377-52-7
Chemical Name: N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide
Synonyms: DK398;tbstfa;MTBSTFA;MBDSTFA;MTBSTFA=TBSTFA;MTBSTFA AND TBDMCS;DEUTERO-REGISIL-D18;MTBSTFA AND TBDMSCL;N-(tert-Butyldimethy;MTBSTFA + 1% TBDMSCl
CBNumber: CB7707814
Molecular Formula: C9H18F3NOSi
Formula Weight: 241.33
MOL File: 77377-52-7.mol

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N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide Property

Boiling point:: 172-175 °C(lit.)
Density: 1.036 g/mL at 25 °C(lit.)
refractive index: n20/D 1.402(lit.)
Flash point:: 127 °F
storage temp.: 2-8°C
solubility: sol most aprotic organic solvents.
pka: -1.50±0.70(Predicted)
form: Liquid
Specific Gravity: 1.023
color: Clear colorless to slightly yellow
Water Solubility: decomposes
Sensitive: Moisture Sensitive
Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents
BRN: 3606546
CAS DataBase Reference: 77377-52-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 10-36/37/38
Safety Statements: 26-36-16-37/39-36/37/39
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
F: 10-21
Hazard Note: Flammable
TSCA: No
HS Code: 2931 90 00
HazardClass: 3
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.14219
Product name: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity: for synthesis
Packaging: 1mL
Price: $65.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: M-108
Product name: MTBSTFA (with 1% t-BDMCS)
Purity: ampule of 5 × 1?mL, (with 1% t-BDMCS), analytical standard, Cerilliant?
Packaging: 5x1mL
Price: $74.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14219
Product name: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity: for synthesis
Packaging: 5ml
Price: $206
Updated: 2024/03/01

Sigma-Aldrich

Product number: 77626
Product name: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity: for GC derivatization, LiChropur?, ≥99.0% (GC)
Packaging: 10ml
Price: $271
Updated: 2024/03/01

Sigma-Aldrich

Product number: 77626
Product name: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity: for GC derivatization, LiChropur?, ≥99.0% (GC)
Packaging: 10X1ML
Price: $352
Updated: 2024/03/01

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N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid

Physical properties

bp 168–170°C; d 1.12 g cm?3.

Uses

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-butyldimethylchlorosilane is commonly used for the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from the hydrolysis of nitrogen mustards. It is also used for selective O-silylation of N,O-diacylhydroxyl amines.

Uses

In the presence of 1% of t-butyldimethylchlorosilane as the catalyst, N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide (BSMTFA) functions as an extremely reactive t-butyldimethylsilylating reagent for alcohols, amines, carboxylic acids, and thiols. Silylation is generally completed within 5 min at 25°C in acetonitrile. This amide is more reactive than N-(t-butyldimethylsilyl)-N-methylacetamide.
In the protection of a hydroxy group, the resultant tbutyldimethylsilyl (TBDMS) ethers are stable under the conditions for acetate saponification and hydrogenation.These silyl ethers also remain intact towards the Jones reagent and Wittig reagents. The TBDMS ethers are approx. 10 times more stable against hydrolysis than the corresponding trimethylsilyl (TMS) ethers.Selective removal of the TBDMS group can be accomplished by use of dilute acetic acid or tetra-n-butylammonium fluoride in THF at 25°C.
Silylation of ketones by use ofBSMTFAoccurs in triethylamine and DMF at 40–60°C to give the corresponding silyl enol ethers in good to excellent yields (eq 1).In addition, silyl ether formation takes place in N-hydroxysuccinimide (88% yield) and Nhydroxypyrrole (99% yield) by use of BSMTFA in THF.

Uses

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide is a silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatogography-mass spectrometry (GC-MS) analysis.

Preparation

obtained in 91% yield by reaction of N-methyl-2,2,2-trifluoroacetamide (1.0 equiv) in benzene and acetonitrile (1:1 v/v) with NaH (1.0 equiv) and then with t-BuMe2SiCl (1.2 equiv) at 4°C.

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a tert-butyldimethylsilyl group.

General Description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a silylating reagent which replaces the active hydrogen with tert-Butyldimethylsilyl group. The tert-Butyldimethylsilyl derivatives are found to be more resistant to hydrolysis and stable compared to trimethylsilyl (TMS) derivatives. This reagent is suitable for GC-MS analysis since it produces mass spectra, which can be easily interpreted. It is widely used for the silylation of different alcohols, thiols, phenols, carboxylic acids, amines, and amides.

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide manufacturers

Career Henan Chemical Co

Product: N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide 77377-52-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-02

77377-52-7, N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamideRelated Search:

METSULFURON METHYL Basic Violet 1 Trifluoroacetamide N-Methylacetamide N,N-Dimethylformamide N,N-Dimethylacetamide Methyl acrylate Tribenuron methyl POLYDIMETHYLSILOXANE Kresoxim-methyl Methylparaben Dimethyl sulfoxide Methyl salicylate Dimethyl sulfone Methanol Poly(dimethylsiloxane) tert-Butyldimethylsilyl chloride Methyl

MBDSTFA

DEUTERO-REGISIL-D18

N-TERT-BUTYLDIME.SILYL-N-ME.TRIFLUOROACE

N-TERT-BUTYLDIME.SILYL-N-ME.TRIFLUOROACE TAMIDE + 1% TBDMSCL

N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYL-TRI FLUOROACETAMIDE, 97+%

N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYLTRIF LUOROACETA

N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYL-TRIFLUOROACETAMIDE, W/1% TBDMSCL, >=95%

N-TERT-BUTYLDIMETHYLSILYL-N-METHYL TRIFL

MTBSTFA=TBSTFA

SILYLATING MIXTURE FLUKA VI

MTBSTFA

MTBSTFA AND TBDMCS

MTBSTFA AND TBDMSCL

N-METHYL(TERT-BUTYLDIMETHYLSILYL)TRIFLUOROACETAMIDE

N-METHYL-N-(T-BUTYLDIMETHYLSILYL)TRIFLUOROACETAMIDE

N-METHYL-N-TERT-BUTYLDIMETHYLSILYLTRIFLUOROACETAMIDE

N-METHYL-N-[TERT-BUTYLDIMETHYL-SILYL]TRIFLUOROACETAMIDE AND TERT-BUTYLDIMETHYLCHLOROSILANE

N-(T-BUTYLDIMETHYLSILYL)-N-METHYLTRIFLUOROACETAMIDE

N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYLTRIFLUORACETAMIDE

N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYLTRIFLUOROACETAMIDE

MTBSTFA + 1% TBDMSCl, MTBSTFA+TBDMSCl, 99:1, Silylating mixture Fluka VI, N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide

MTBSTFA + 1% TBDMSCl, Silylating mixture Fluka VI, N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide

Acetamide, N-(1,1-dimethylethyl)dimethylsilyl-2,2,2-trifluoro-N-methyl-

N-(tert-B-butyldimethylsilyl)-n-methyl- trifluoroacetamide, 98%

N-Methyl-N-(tert-butyldimethylsilyl)-2,2,2-trifluoroacetamide

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide,98%

N-Methyl-N-[Tert-Butyld

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane,N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide, MTBSTFA + 1% TBDMSCl, MTBSTFA+TBDMSCl, 99:1, Silylatin

N-(tert-Butyldimethy

MTBSTFA (with 1% t-BDMCS)

N-[(tert-Butyl)dimethylsilyl]-N-methyl-2,2,2-trifluoroacetamide, [Methyl(trifluoroacetyl)amino]dimethylsilane

[tert-butyl-(2,2,2-trifluoro-1-oxoethyl)amino]methyl-dimethylsilicon

MTBSTFA + 1% TBDMSCl

MTBSTFA (N-(tert-butyldiMethylsilyl)-N-METHYLTRIFLUOROACETAMIDE)

MTBSTFA /1% tert-butyldiMethylchlorosilane

N-tert-ButyldiMethylsilyl-N-MethyltrifluoroacetaMide with 1% tert-ButyldiMethylchlorosilane >=95%

n-tert-butyldimethylsilyl-n-methyltrifluoroacetamide with 1% tert-butyldimethylchlorosilane

tbstfa

N-Methyl-(tert-Butydimethylsilyl)-trifluoroacetamide

N-Methyl(tert-butyldimethylsilyl)trifluoroacetamide 95%

N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide 99+%

N-Methyl(tert-butyldimethylsilyl)trifluoroacetamide95%

N-Methyl-N-(tert-butyldimethylsilyl)trifluoro-

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA)

MTBSTFA+TBDMSCl, 99:1

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide >=97.0% (GC)

N-[(1,1-DiMethylethyl)diMethylsilyl]-2,2,2-trifluoro-N-MethylacetaMide

N-Methyl-N-(tert-butyldiMethylsilyl)-1,1,1-trifluoroacetaMide

N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide MTBSTFA

N-TERT-BUTYLDIMETHYLSILYL-N-METHYLTRIFLU

N-[(tert-Butyl)dimethylsilyl]-N-methyltrifluoroacetamide 97%

N-(tert-ButyldiMethylsilyl)-N-Methyl-trifluoroacetaMide, 98% 1GR

N-(t-butyldiMethylsilyl)-N-MethyltrifluoroacetaMide with N-(t-butlydiMethylsilylchloride)

N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide

N-(t-Butyldimethylsilyl)-N-methyltrifluoroacetamid

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide &gt

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (Technical Grade)

DK398