ChemicalBook > CAS DataBase List > BQ-788

BQ-788

Product Name: BQ-788
CAS No.: 156161-89-6
Chemical Name: BQ-788
Synonyms: CS-1494;BQ-788 SODIUM;BQ789 Sodium Salt;1-ELAIDYLPHOSPHOCHOLINE, >97%;BQ788 SODIUM SALT; BQ 788 SODIUM SALT;BQ 788 sodium salt, ETB receptor antagonist;BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT;N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-;N-cis-2,6-dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa;2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
CBNumber: CB7710904
Molecular Formula: C34H52N5NaO7
Formula Weight: 665.81
MOL File: 156161-89-6.mol

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BQ-788 Property

storage temp.: -20°C
solubility: acetonitrile: 0.3 mg/mL
form: solid
color: white
Water Solubility: acetonitrile: 0.3mg/mL
DMSO: 1.2mg/mL
ethanol: 1.2mg/mL
H2O: slightly soluble
InChIKey: IBWYJVKAVOHKHB-IAZAOAQXNA-N
SMILES: C(C1=CN(C(=O)OC)C2=CC=CC=C12)[C@H](C(=O)N[C@@H](C(=O)O)CCCC)NC(=O)[C@H](CC(C)(C)C)NC(N1[C@@H](CCC[C@@H]1C)C)=O.[NaH] |&1:14,18,29,38,42,r|

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B157
Product name: BQ-788
Purity: ≥95%,solid
Packaging: 200μg
Price: $249
Updated: 2025/07/31

Cayman Chemical

Product number: 17403
Product name: BQ-788 (sodium salt)
Purity: ≥95%
Packaging: 500μg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 17403
Product name: BQ-788 (sodium salt)
Purity: ≥95%
Packaging: 1mg
Price: $242
Updated: 2024/03/01

TRC

Product number: B676670
Product name: BQ788
Packaging: 5mg
Price: $595
Updated: 2021/12/16

ChemScene

Product number: CS-2685
Product name: BQ-788(sodiumsalt)
Purity: 98.03%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

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BQ-788 Chemical Properties,Usage,Production

Uses

BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs), uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs), and human umbilical vein endothelial cells (HUVECs)

Biological Activity

Potent, selective ET B receptor antagonist (IC 50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).

Biochem/physiol Actions

Selective ETB endothelin receptor antagonist.

in vivo

BQ-788 (3 mg/kg/h, i.v.) completely inhibits a pharmacological dose of ET-1- or sarafotoxin6c (0.5 nmol/kg, i.v.)-induced ETB receptor-mediated depressor, but not pressor responses in conscious rats. Furthermore, BQ-788 markedly increases the plasma concentration of ET-1, which is considered an index of potential ETB receptor blockade in vivo. In Dahl salt-sensitive hypertensive (DS) rats, BQ-788 (3 mg/kg/h, i.v.) increases blood pressure by about 20 mm Hg. It is reported that BQ-788 also inhibits ET-1-induced bronchoconstriction, tumor growth and lipopolysaccharide-induced organfailure^[1]. BQ 788 (3 mg/kg) results in an eightfold leftward shift in the ET-1 dose-response curve, suggesting a significant involvement of ETB dilator receptors^[2]. Mice are treated with 30 nmol BQ-788 by intraplantar, reduce mechanical hyperalgesia (47% and 42%), thermal hyperalgesia (68% and 76%), oedema (50% and 30%); myeloperoxidase activity (64% and 32%), and overt-pain like behaviours. Additionally, intraplantar treatment with clazosentan or BQ-788 decreases spinal (45% and 41%) and peripheral (47% and 47%) superoxide anion production as well as spinal (47% and 47%) and peripheral (33% and 54%) lipid peroxidation, respectively^[3].

IC 50

ET_B

storage

+4°C

BQ-788 Preparation Products And Raw materials

Raw materials

Preparation Products

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BQ-788 Suppliers

China 51 Europe 1 Germany 3 India 1 Switzerland 1 United Kingdom 3 United States 16 Global 76

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156161-89-6, BQ-788Related Search:

Sodium salt EPT AC-D-NLE-OH N-ACETYL-D-ALA-D-ALA METHYL PYRROLE-1-CARBOXYLATE BQ-788

BQ-788 SODIUM

BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT

N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucinesodiumsalt

1-ELAIDYLPHOSPHOCHOLINE, >97%

N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt, 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle

N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-

DMpc-gaMMa-MeLeu-D-Trp(1-CO2CH3)-D-Nle.Na (DMpc : cis-2,6-DiMethylpiperidinocarbonyl)

2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle

N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt

BQ789 Sodium Salt

N-cis-2,6-dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa

BQ788 SODIUM SALT; BQ 788 SODIUM SALT

CS-1494

sodium,(2R)-2-[[(2R)-2-amino-3-(1-methoxycarbonylindol-3-yl)propanoyl]-[(2S)-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]hexanoate

D-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, sodium salt (1:1)

Sodium (R)-2-((R)-2-((S)-2-((2R,6S)-2,6-dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoate

BQ 788 sodium salt, ETB receptor antagonist

156161-89-6

C34H51N5NaO7

C34H50N5O7Na

C34H50N5NaO7

Endothelin receptor