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BQ-788

Product Name
BQ-788
CAS No.
156161-89-6
Chemical Name
BQ-788
Synonyms
CS-1494;BQ-788 SODIUM;BQ789 Sodium Salt;1-ELAIDYLPHOSPHOCHOLINE, >97%;BQ788 SODIUM SALT; BQ 788 SODIUM SALT;BQ 788 sodium salt, ETB receptor antagonist;BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT;N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-;N-cis-2,6-dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa;2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
CBNumber
CB7710904
Molecular Formula
C34H52N5NaO7
Formula Weight
665.81
MOL File
156161-89-6.mol
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BQ-788 Property

storage temp. 
-20°C
solubility 
acetonitrile: 0.3 mg/mL
form 
solid
color 
white
Water Solubility 
acetonitrile: 0.3mg/mL
DMSO: 1.2mg/mL
ethanol: 1.2mg/mL
H2O: slightly soluble
InChIKey
IBWYJVKAVOHKHB-IAZAOAQXNA-N
SMILES
C(C1=CN(C(=O)OC)C2=CC=CC=C12)[C@H](C(=O)N[C@@H](C(=O)O)CCCC)NC(=O)[C@H](CC(C)(C)C)NC(N1[C@@H](CCC[C@@H]1C)C)=O.[NaH] |&1:14,18,29,38,42,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B157
Product name
BQ-788
Purity
≥95%,solid
Packaging
200μg
Price
$249
Updated
2025/07/31
Cayman Chemical
Product number
17403
Product name
BQ-788 (sodium salt)
Purity
≥95%
Packaging
500μg
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
17403
Product name
BQ-788 (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$242
Updated
2024/03/01
TRC
Product number
B676670
Product name
BQ788
Packaging
5mg
Price
$595
Updated
2021/12/16
ChemScene
Product number
CS-2685
Product name
BQ-788(sodiumsalt)
Purity
98.03%
Packaging
1mg
Price
$180
Updated
2021/12/16
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BQ-788 Chemical Properties,Usage,Production

Uses

BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs), uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs), and human umbilical vein endothelial cells (HUVECs)

Biological Activity

Potent, selective ET B receptor antagonist (IC 50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).

Biochem/physiol Actions

Selective ETB endothelin receptor antagonist.

in vivo

BQ-788 (3 mg/kg/h, i.v.) completely inhibits a pharmacological dose of ET-1- or sarafotoxin6c (0.5 nmol/kg, i.v.)-induced ETB receptor-mediated depressor, but not pressor responses in conscious rats. Furthermore, BQ-788 markedly increases the plasma concentration of ET-1, which is considered an index of potential ETB receptor blockade in vivo. In Dahl salt-sensitive hypertensive (DS) rats, BQ-788 (3 mg/kg/h, i.v.) increases blood pressure by about 20 mm Hg. It is reported that BQ-788 also inhibits ET-1-induced bronchoconstriction, tumor growth and lipopolysaccharide-induced organfailure[1]. BQ 788 (3 mg/kg) results in an eightfold leftward shift in the ET-1 dose-response curve, suggesting a significant involvement of ETB dilator receptors[2]. Mice are treated with 30 nmol BQ-788 by intraplantar, reduce mechanical hyperalgesia (47% and 42%), thermal hyperalgesia (68% and 76%), oedema (50% and 30%); myeloperoxidase activity (64% and 32%), and overt-pain like behaviours. Additionally, intraplantar treatment with clazosentan or BQ-788 decreases spinal (45% and 41%) and peripheral (47% and 47%) superoxide anion production as well as spinal (47% and 47%) and peripheral (33% and 54%) lipid peroxidation, respectively[3].

IC 50

ETB

storage

+4°C

BQ-788 Preparation Products And Raw materials

Raw materials

Preparation Products

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BQ-788 Suppliers

China 51 Europe 1 Germany 3 India 1 Switzerland 1 United Kingdom 3 United States 16 Global 76

156161-89-6, BQ-788Related Search:

Sodium salt EPT AC-D-NLE-OH N-ACETYL-D-ALA-D-ALA METHYL PYRROLE-1-CARBOXYLATE BQ-788

  • BQ-788 SODIUM
  • BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT
  • N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucinesodiumsalt
  • 1-ELAIDYLPHOSPHOCHOLINE, >97%
  • N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt, 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
  • N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-
  • DMpc-gaMMa-MeLeu-D-Trp(1-CO2CH3)-D-Nle.Na (DMpc : cis-2,6-DiMethylpiperidinocarbonyl)
  • 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
  • N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt
  • BQ789 Sodium Salt
  • N-cis-2,6-dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa
  • BQ788 SODIUM SALT; BQ 788 SODIUM SALT
  • CS-1494
  • sodium,(2R)-2-[[(2R)-2-amino-3-(1-methoxycarbonylindol-3-yl)propanoyl]-[(2S)-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]hexanoate
  • D-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, sodium salt (1:1)
  • Sodium (R)-2-((R)-2-((S)-2-((2R,6S)-2,6-dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoate
  • BQ 788 sodium salt, ETB receptor antagonist
  • 156161-89-6
  • C34H51N5NaO7
  • C34H50N5O7Na
  • C34H50N5NaO7
  • Endothelin receptor