FORTUNELLIN
- Product Name
- FORTUNELLIN
- CAS No.
- 20633-93-6
- Chemical Name
- FORTUNELLIN
- Synonyms
- FORTUNELLIN;ACACETIN-7-NEOHESPERIDOSIDE;ACACETIN-7-O-NEOHESPERIDOSIDE;4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-
- CBNumber
- CB7713662
- Molecular Formula
- C28H32O14
- Formula Weight
- 592.55
- MOL File
- 20633-93-6.mol
FORTUNELLIN Property
- Melting point:
- 193-198°C
- Boiling point:
- 888.7±65.0 °C(Predicted)
- Density
- 1.62±0.1 g/cm3(Predicted)
- pka
- 6.10±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- OA71574
- Product name
- Acacetin-7-neohesperidoside
- Packaging
- 5mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- CHM0029941
- Product name
- FORTUNELLIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $933.82
- Updated
- 2021/12/16
- Product number
- OA71574
- Product name
- Acacetin-7-neohesperidoside
- Packaging
- 10mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- OA71574
- Product name
- Acacetin-7-neohesperidoside
- Packaging
- 25mg
- Price
- $2500
- Updated
- 2021/12/16
- Product number
- OA71574
- Product name
- Acacetin-7-neohesperidoside
- Packaging
- 1mg
- Price
- $300
- Updated
- 2021/12/16
FORTUNELLIN Chemical Properties,Usage,Production
Description
Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.
Chemical Properties
Off-white to light yellow Solid
Uses
Fortunellin is a flavonoid that can be isolated from kumquat (Fortunella margarita) fruit. Studies have shown that Fortunellin inhibits LPS-induced inflammation and ROS production in H9C2 cells, and also prevents fructose-induced inflammation and oxidative stress by enhancing the AMPK/Nrf2 pathway. In addition, Fortunellin has a dual role in the prevention and treatment of coronaviral disease, with antiviral activity against SARS-CoV-2 and anti-inflammatory immunomodulatory capacity in the host.
Biological Functions
Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.
Mechanism of action
Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis.