ChemicalBook > CAS DataBase List > 1-Benzyl-3-piperidinol

1-Benzyl-3-piperidinol

Product Name
1-Benzyl-3-piperidinol
CAS No.
14813-01-5
Chemical Name
1-Benzyl-3-piperidinol
Synonyms
N-BENZYL-3-HYDROXYPIPERIDINE;1-benzyl-3-piperidol;1-Benzyl-3-piperidin;1-Bezyl-3-piperidinol;Benidipine Impurity 8;N-BENZYL-3-PIPERIDINOL;1-BENZYL-3-PIPERIDINOL;1-BENZYL-PIPERIDIN-3-OL;1-Benzoyl-3-piperidinol;1-benzyl-3-piperdin-3-ol
CBNumber
CB7718344
Molecular Formula
C12H17NO
Formula Weight
191.27
MOL File
14813-01-5.mol
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1-Benzyl-3-piperidinol Property

Boiling point:
140-142°C 6mm
Density 
1,056 g/cm3
refractive index 
n20/D 1.549
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
clear liquid
pka
14.82±0.20(Predicted)
color 
Colorless to Light yellow
Sensitive 
Hygroscopic
BRN 
135964
InChI
InChI=1S/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2
InChIKey
UTTCOAGPVHRUFO-UHFFFAOYSA-N
SMILES
N1(CC2=CC=CC=C2)CCCC(O)C1
CAS DataBase Reference
14813-01-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
2
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
653446
Product name
N-Benzyl-3-hydroxypiperidine
Purity
97%
Packaging
1g
Price
$80.3
Updated
2023/01/07
Sigma-Aldrich
Product number
653446
Product name
N-Benzyl-3-hydroxypiperidine
Purity
97%
Packaging
5g
Price
$288
Updated
2023/01/07
TCI Chemical
Product number
B4868
Product name
1-Benzyl-3-hydroxypiperidine
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$89
Updated
2025/07/31
TCI Chemical
Product number
B4868
Product name
1-Benzyl-3-hydroxypiperidine
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$267
Updated
2025/07/31
Biosynth Carbosynth
Product number
FB76189
Product name
1-Benzyl-3-piperidinol
Packaging
10g
Price
$160
Updated
2021/12/16
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1-Benzyl-3-piperidinol Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Reactant for bioresolution of tertiary amino ester protic ionic liquids using subtilisin

Reactant for synthesis of:

  • Muscarinic M3 selective antagonists
  • Rho kinase inhibitors
  • Piperidine derivatives for investigations into α-adrenoreceptor direct activation

Synthesis

40114-49-6

14813-01-5

General procedure for the synthesis of 1-benzyl-3-piperidinol from 1-benzyl-3-piperidone: first, N-benzyl-3-piperidone hydrochloride was converted to a free base by the addition of an aqueous solution of K2CO3, which was subsequently extracted with ethyl acetate. Next, sodium borohydride (NaBH4) (0.438 g, 11.57 mmol) was slowly added to an ethanol solution containing N-benzyl-3-piperidone (2.19 g, 11.57 mmol) over 10 min. The reaction mixture was stirred overnight at room temperature and then concentrated under vacuum. The concentrated residue was dissolved in 1.0 N HCl and washed twice with diethyl ether. Afterwards, the aqueous phase was adjusted to pH 12 with 3.0N KOH and extracted three times with dichloromethane. The organic phases were combined and dried with Na2SO4, followed by vacuum concentration. The purity of the crude product was 100% (1.900 g, 86% yield) by IC/MS (EI) analysis: m/z 192.3 (M+1).

Waste Disposal

2,4-Dichloro-5-methoxypyrimidine is a halogen-containing aromatic ring organic compound, which is more harmful to the water environment. Therefore, undiluted or large amounts of 2,4-dichloro-5-methoxypyrimidine should not be exposed to groundwater, waterways, or sewage systems.

References

[1] Patent: WO2005/26145, 2005, A2. Location in patent: Page/Page column 98
[2] Process Biochemistry, 2017, vol. 56, p. 90 - 97

1-Benzyl-3-piperidinol Preparation Products And Raw materials

Raw materials

Preparation Products

Benidipine
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View Lastest Price from 1-Benzyl-3-piperidinol manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1-Benzyl-3-piperidinol 14813-01-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Anhui Dexinjia Biopharm Co., Ltd
Product
1-Benzyl-3-hydroxypiperide 14813-01-5
Price
US $15.00-50.00/kg
Min. Order
1kg
Purity
NLT98%
Supply Ability
5 ton per month
Release date
2023-03-26
Anhui Yiao New Material Technology Co., Ltd
Product
1-Benzyl-3-Piperidinol 14813-01-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-11-02

14813-01-5, 1-Benzyl-3-piperidinolRelated Search:

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