6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
- Product Name
- 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
- CAS No.
- 63744-22-9
- Chemical Name
- 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
- Synonyms
- 8-dibroMoiMidazo[1;6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE;6,8-Dibromoimidazol[1,2-a]pyrazine;IMidazo[1,2-a]pyrazine, 6,8-dibroMo-;6,8-Dibromoimidazo[1,2-a]pyrazine>6,8-Dibromoimidazo[1,2-a]pyrazine,95%;6,8-Dibromo imidazole [1,2-A] pyrazine
- CBNumber
- CB7726277
- Molecular Formula
- C6H3Br2N3
- Formula Weight
- 276.92
- MOL File
- 63744-22-9.mol
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Property
- Melting point:
- 165.0 to 169.0 °C
- Density
- 2.35±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -0.36±0.30(Predicted)
- color
- White to Amber
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H3Br2N3/c7-4-3-11-2-1-9-6(11)5(8)10-4/h1-3H
- InChIKey
- UQCZZGIPIMJBCL-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1C=C(Br)N=C2Br
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D4967
- Product name
- 6,8-Dibromoimidazo[1,2-a]pyrazine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- D4967
- Product name
- 6,8-Dibromoimidazo[1,2-a]pyrazine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- D425495
- Product name
- 6,8-Dibromoimidazo[1,2-a]pyrazine
- Packaging
- 10g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- CAPOD11638
- Product name
- 6,8-Dibromoimidazo[1,2-a]pyrazine
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- OR16939
- Product name
- 6,8-Dibromoimidazo[1,2-a]pyrazine
- Packaging
- 5g
- Price
- $41
- Updated
- 2021/12/16
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Chemical Properties,Usage,Production
Uses
6,8-Dibromoimidazo[1,2-a]pyrazine is a imidazopyrazine derivative with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties. 6,8-Dibromoimidazo[1,2-a]pyrazine also displays theophylline-like properties.
Uses
It is an Intermediate in organic syntheses.
Synthesis
7252-83-7
24241-18-7
63744-22-9
1. 3,5-dibromopyrazin-2-amine (1018 g, 4.03 mol) was dissolved in water (10 kg) at room temperature. 2. 2-bromo-1,1-dimethoxyethane (1.79 kg, 4.14 mol) was added to the above solution and mixed with stirring. 3. The reaction mixture was heated to reflux and held for 2 hours. 4. After the reaction was complete, water (15.3 kg) and sodium bicarbonate (744 g) were added to the reaction solution and stirring was continued for 15 minutes. 5. The reaction mixture was filtered and the solid product was collected. 6. 6. After drying, 6,8-dibromoimidazo[1,2-A]pyrazine (1106 g, 3.99 mmol, 99% yield) was obtained as a brown solid. 7. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 7.90 (s, 1H), 8.23 (s, 1H), 9.02 (s, 1H).
References
[1] Patent: US2012/59162, 2012, A1. Location in patent: Page/Page column 53-54
[2] Patent: WO2005/85252, 2005, A1. Location in patent: Page/Page column 37-38; 40-41
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 512 - 516
[4] Patent: WO2016/209895, 2016, A1. Location in patent: Paragraph 15; 16
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE manufacturers
- Product
- 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE 63744-22-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-08-29
- Product
- 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE 63744-22-9
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24