ChemicalBook > CAS DataBase List > 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE

Product Name
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
CAS No.
63744-22-9
Chemical Name
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
Synonyms
8-dibroMoiMidazo[1;6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE;6,8-Dibromoimidazol[1,2-a]pyrazine;IMidazo[1,2-a]pyrazine, 6,8-dibroMo-;6,8-Dibromoimidazo[1,2-a]pyrazine>6,8-Dibromoimidazo[1,2-a]pyrazine,95%;6,8-Dibromo imidazole [1,2-A] pyrazine
CBNumber
CB7726277
Molecular Formula
C6H3Br2N3
Formula Weight
276.92
MOL File
63744-22-9.mol
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6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Property

Melting point:
165.0 to 169.0 °C
Density 
2.35±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-0.36±0.30(Predicted)
color 
White to Amber
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C6H3Br2N3/c7-4-3-11-2-1-9-6(11)5(8)10-4/h1-3H
InChIKey
UQCZZGIPIMJBCL-UHFFFAOYSA-N
SMILES
C12=NC=CN1C=C(Br)N=C2Br
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4967
Product name
6,8-Dibromoimidazo[1,2-a]pyrazine
Purity
>98.0%(GC)
Packaging
1g
Price
$54
Updated
2025/07/31
TCI Chemical
Product number
D4967
Product name
6,8-Dibromoimidazo[1,2-a]pyrazine
Purity
>98.0%(GC)
Packaging
5g
Price
$192
Updated
2025/07/31
TRC
Product number
D425495
Product name
6,8-Dibromoimidazo[1,2-a]pyrazine
Packaging
10g
Price
$1230
Updated
2021/12/16
Matrix Scientific
Product number
069985
Product name
6,8-Dibromoimidazo[1,2-a]pyrazine
Purity
>95%
Packaging
5g
Price
$2999
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD140693
Product name
6,8-Dibromoimidazo[1,2-a]pyrazine
Packaging
2g
Price
$60
Updated
2021/12/16
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6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Chemical Properties,Usage,Production

Uses

6,8-Dibromoimidazo[1,2-a]pyrazine is a imidazopyrazine derivative with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties. 6,8-Dibromoimidazo[1,2-a]pyrazine also displays theophylline-like properties.

Uses

It is an Intermediate in organic syntheses.

Synthesis

7252-83-7

24241-18-7

63744-22-9

1. 3,5-dibromopyrazin-2-amine (1018 g, 4.03 mol) was dissolved in water (10 kg) at room temperature. 2. 2-bromo-1,1-dimethoxyethane (1.79 kg, 4.14 mol) was added to the above solution and mixed with stirring. 3. The reaction mixture was heated to reflux and held for 2 hours. 4. After the reaction was complete, water (15.3 kg) and sodium bicarbonate (744 g) were added to the reaction solution and stirring was continued for 15 minutes. 5. The reaction mixture was filtered and the solid product was collected. 6. 6. After drying, 6,8-dibromoimidazo[1,2-A]pyrazine (1106 g, 3.99 mmol, 99% yield) was obtained as a brown solid. 7. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 7.90 (s, 1H), 8.23 (s, 1H), 9.02 (s, 1H).

References

[1] Patent: US2012/59162, 2012, A1. Location in patent: Page/Page column 53-54
[2] Patent: WO2005/85252, 2005, A1. Location in patent: Page/Page column 37-38; 40-41
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 512 - 516
[4] Patent: WO2016/209895, 2016, A1. Location in patent: Paragraph 15; 16

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Suppliers

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View Lastest Price from 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE 63744-22-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000
Release date
2025-08-29
Career Henan Chemical Co
Product
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE 63744-22-9
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

63744-22-9, 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINERelated Search:

Acetylene 1,4-Dibromobenzene 1,2-DIBROMOETHYLENE Dibromomethane ACETONE-D6 IMidazo[1,2-a]pyridine, 6,8-dibroMo- Imidazo[1,2-a]pyrazin-8-amine (9CI) 6-bromoimidazo[1,2-a]pyrazin-8-amine 6,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine 6,8-Dibromo-2-methylimidazo[1,2-a]pyrazine 6,8-Dibromoimidazo[1,2-a]pyrazine-3-carbaldehyde 3,5-Dibromo-imidazo[1,2-a]pyrazine 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE IMIDAZO[1,2-A]PYRAZINE 6-Bromoimidazo[1,2-a]pyrazine 2-(Bromomethyl)imidazole

  • 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
  • 6,8-Dibromoimidazol[1,2-a]pyrazine
  • IMidazo[1,2-a]pyrazine, 6,8-dibroMo-
  • 8-dibroMoiMidazo[1
  • 6,8-Dibromoimidazo[1,2-a]pyrazine&gt
  • 6,8-Dibromoimidazo[1,2-a]pyrazine,95%
  • 6,8-Dibromo imidazole [1,2-A] pyrazine
  • 63744-22-9
  • C6H3Br2N3
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • CHIRAL CHEMICALS
  • Heterocycles series