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CCPA

Product Name
CCPA
CAS No.
37739-05-2
Chemical Name
CCPA
Synonyms
CCPA;CCPA USP/EP/BP;2-Chloro-N-cyclop;N-Cyclopentyl-2-chloroadenosine;2-CHLORO-N-CYCLOPENTYLADENOSINE;2-chloro-n-cyclopentyl-adenosin;2-CHLORO-N6-CYCLOPENTYLADENOSINE;Adenosine, 2-chloro-N-cyclopentyl-;2-chloro-N(sup 6)-cyclopentyladenosine;2-Chloro-N≤sup>=6≤/sup>=-cyclopentyladenosine
CBNumber
CB7751716
Molecular Formula
C15H20ClN5O4
Formula Weight
369.8
MOL File
37739-05-2.mol
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CCPA Property

Boiling point:
656.1±65.0 °C(Predicted)
Density 
1.87±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: 1.7 mg/mL, insoluble
form 
solid
pka
13.06±0.70(Predicted)
color 
off-white to light yellow
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
AU7357555
HS Code 
29349990
Toxicity
mouse,LD,intraperitoneal,> 100mg/kg (100mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Arzneimittel-Forschung. Drug Research. Vol. 44, Pg. 1305, 1994.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C7938
Product name
2-Chloro-N6-cyclopentyladenosine
Purity
adenosine receptor agonist
Packaging
10mg
Price
$253
Updated
2024/03/01
Tocris
Product number
1705
Product name
2-Chloro-N6-cyclopentyladenosine
Purity
≥98%(HPLC)
Packaging
10
Price
$159
Updated
2021/12/16
Tocris
Product number
1705
Product name
2-Chloro-N6-cyclopentyladenosine
Purity
≥98%(HPLC)
Packaging
50
Price
$658
Updated
2021/12/16
Usbiological
Product number
295610
Product name
2-Chloro-N6-cyclopentyladenosine hemihydrate
Packaging
2mg
Price
$409
Updated
2021/12/16
Usbiological
Product number
254355
Product name
2-Chloro-N6-cyclopentyladenosine
Packaging
10mg
Price
$423
Updated
2021/12/16
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CCPA Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

Adenosine receptors are for treating central nervous system (CNS) disorders. Adenosine A1 receptor agonists include e.g. CCPA, 8-cyclopentyl-1,3-dipropylxanthine, R-phenylisopropyl adenosine. A2A rec eptor agonists include e.g. regadenoson (Lexiscan), apadenoson, binodenoson.

Uses

2-Chloro-N6-cyclopentyl Adenosine is a selective adenosine receptor agonist (1,2). It inhibits angiotensin II induced cardiomyocyte hypertrophy via the calcineurin signaling pathway (2).

Uses

2-Chloro-N6-cyclopentyladenosine (CCPA) may be used as an A1 adenosine receptor agonist with high selectivity. CCPA is often used with other adenosine receptor agonists and antagonist to resolve A(1), A(2A) and A(3) receptor functions. These include DPCPX (A(1) receptor antagonist), 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-α][1,3,5]triazin-5-ylamino]ethyl)phenol (A(2A) receptor antagonist), and 4-[2-[[6-amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride (A(2A) receptor agonist), and Cl-IB-MECA, (A(3)) receptor agonist).

Biological Activity

Potent and selective adenosine A 1 receptor agonist (K i values are 0.8, 2300 and 42 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 18800 nM for hA 2B ). Centrally active following systemic administration in vivo .

Biochem/physiol Actions

A1 adenosine receptor agonist with high selectivity: reportedly 10,000-fold for A1 over A2 receptors.

storage

Desiccate at RT

References

[1]. lohse mj, klotz kn, schwabe u, et al. 2-chloro-n6-cyclopentyladenosine: a highly selective agonist at a1 adenosine receptors. naunyn schmiedebergs arch pharmacol, 1988, 337(6): 687-689.
[2]. monopoli a, conti a, dionisotti s, et al. pharmacology of the highly selective a1 adenosine receptor agonist 2-chloro-n6-cyclopentyladenosine. arzneimittelforschung, 1994, 44(12): 1305-1312.
[3]. concas a, santoro g, mascia mp, et al. anticonvulsant doses of 2-chloro-n6-cyclopentyladenosine, an adenosine a1 receptor agonist, reduce gabaergic transmission in different areas of the mouse brain. j pharmacol exp ther, 1993, 267(2): 844-851.
[4]. sandoli d, chiu pj, chintala m, et al. in vivo and ex vivo effects of adenosine a1 and a2 receptor agonists on platelet aggregation in the rabbit. eur j pharmacol, 1994, 259(1): 43-49.

CCPA Preparation Products And Raw materials

Raw materials

Preparation Products

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CCPA Suppliers

Canada 1 China 55 Germany 3 India 1 Japan 1 Switzerland 1 United Kingdom 5 United States 13 Global 80
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View Lastest Price from CCPA manufacturers

Career Henan Chemical Co
Product
CCPA 37739-05-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 563
Release date
2019-09-01

37739-05-2, CCPARelated Search:

2-Chloropurine Adenine Sulfate 4-Cyanocinnamic acid 2-Chloroadenine 2-Chloroadenosine Adenine hydrochloride Adenine hydrochloride hemihydrate Cyclopentylamine Cladribine 2-chloro-9-methyl-9H-purine 2'-MECCPA 2-chloro-N-ethylpyrimidin-4-amine CCPA N6-CYCLOPENTYLADENOSINE 4-Pyrimidinamine, 2-chloro-N-methyl- (9CI) Adenosinehydrochloride 2-chloro-N-(1-methylethyl)pyrimidin-4-amine 2-CHLORO-N-METHYL-9H-PURIN-6-AMINE

  • CCPA
  • 2-CHLORO-N-CYCLOPENTYLADENOSINE
  • 2-CHLORO-N6-CYCLOPENTYLADENOSINE
  • 2-chloro-n-cyclopentyl-adenosin
  • 2-chloro-N(sup 6)-cyclopentyladenosine
  • 2-Chloro-N6-cyclopentyladenosine hemihydrate
  • 2-CHLORO-N6-CYCLOPENTYLADENOSINE (CCPA) A1 ADENOSINE RECEPTOR
  • N-Cyclopentyl-2-chloroadenosine
  • Adenosine, 2-chloro-N-cyclopentyl-
  • 2-Chloro-N≤sup>=6≤/sup>=-cyclopentyladenosine
  • (2R,3R,4S,5R)-2-[2-Chloro-6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 2-Chloro-N-cyclop
  • CCPA USP/EP/BP
  • 2-Chloro-N6-cyclopentyladenosine 2-Chloro-N6-cyclopentyladenosine
  • 2 Chloro N6 cyclopentyladenosine,2ChloroN6cyclopentyladenosine,2-Chloro-N-6-cyclopentyladenosine
  • 37739-05-2
  • C15H20ClN5O405H2O
  • C15H20CIN5O4
  • C15H20ClN5O4H2O
  • C15H20ClN5O4
  • C15H20N5O4Cl
  • Biochemicals and Reagents
  • BioChemical
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Adenosines/P2 Nucleotide Receptors (Purinergics)
  • Adenosine receptor
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Agonists
  • Neurotransmitters