2-Chloroadenine
- Product Name
- 2-Chloroadenine
- CAS No.
- 1839-18-5
- Chemical Name
- 2-Chloroadenine
- Synonyms
- CHLOROADENINE;NSC 7362;oroadenine;2-chloropurin;2-CHLOROADENINE;2-Chloroadenine 97%;2-Chloroadenine >2-Chlorophenthiazine;2-Chloroadenine ,98%;Cladribine Impurity 3
- CBNumber
- CB7241389
- Molecular Formula
- C5H4ClN5
- Formula Weight
- 169.57
- MOL File
- 1839-18-5.mol
2-Chloroadenine Property
- Melting point:
- >300°C(dec)
- Boiling point:
- 279.76°C (rough estimate)
- Density
- 1.4937 (rough estimate)
- refractive index
- 1.6110 (estimate)
- storage temp.
- -20°C
- solubility
- Aqueous Base (Slightly), DMSO (Very Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 7.17±0.20(Predicted)
- color
- Pale yellow
- Water Solubility
- 8.3mg/L(25 ºC)
- λmax
- 264nm(lit.)
- InChI
- InChI=1S/C5H4ClN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
- InChIKey
- HBJGQJWNMZDFKL-UHFFFAOYSA-N
- SMILES
- NC1N=C(N=C2N=CNC2=1)Cl
- CAS DataBase Reference
- 1839-18-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0000610
- Product name
- Cladribine impurity C
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 5 mg
- Price
- $156
- Updated
- 2025/07/31
- Product number
- 717592
- Product name
- 2-Chloroadenine
- Purity
- 97%
- Packaging
- 500mg
- Price
- $87.8
- Updated
- 2025/07/31
- Product number
- Y0000610
- Product name
- Cladribine impurity C
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000610
- Price
- $153
- Updated
- 2024/03/01
- Product number
- C2575
- Product name
- 2-Chloroadenine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- C2575
- Product name
- 2-Chloroadenine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $259
- Updated
- 2025/07/31
2-Chloroadenine Chemical Properties,Usage,Production
Description
2-Chloroadenine is a heterocyclic building block that has been used in the synthesis of adenosine antimetabolites with antineoplastic activity. It is also the major catabolite of 2-chloro-2’-deoxyadenosine.
Chemical Properties
Pale Yellow Solid
Uses
2-Chloroadenine is a compound useful in organic synthesis used in the preparation of 8-oxadenine derivatives.
Synthesis
5451-40-1
1839-18-5
Preparation of 2-chloroadenine: 2,6-dichloropurine (0.877 kg, 4.64 mol) was placed in a 20 L autoclave and a methanol solution of ammonia (7.0 N, 6.95 kg) was added. After sealing the autoclave, stirring was initiated and the mixture was heated to 100 °C. The reaction was maintained at this temperature for 17 hours. After completion of the reaction, the mixture was cooled to room temperature. After complete cooling, the autoclave was opened and the reaction mixture was diluted with deionized water (3.5 kg). The resulting solid suspension was collected by filtration and the filter cake was washed with methanol (2 x 0.7 kg). Subsequently, the product was dried to constant weight in a vacuum oven at 40 °C to afford 2-chloroadenine as a light yellow solid (0.725 kg, 4.28 mol, 92% yield).
References
[1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 24, p. 5501 - 5508
[2] Heterocycles, 2013, vol. 87, # 11, p. 2369 - 2384
[3] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 1127 - 1130
[4] Patent: WO2005/70947, 2005, A1. Location in patent: Page/Page column 12-13
[5] Patent: WO2018/19681, 2018, A1. Location in patent: Page/Page column 46; 47
2-Chloroadenine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloroadenine manufacturers
- Product
- 2-Chloroadenine 1839-18-5
- Price
- US $2857.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1T
- Release date
- 2021-06-22
- Product
- 2-chloroadenine 1839-18-5
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11
- Product
- 2-Chloroadenine 1839-18-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10