Xanthine
- Product Name
- Xanthine
- CAS No.
- 69-89-6
- Chemical Name
- Xanthine
- Synonyms
- XANTHINE;Xan;Xanthin;ISOXANTHINE;3,7-Dihydro-1H-purine-2,6-dione;7H-xanthine;9H-PURINE-2,6-DIOL;1H-Purine-2,6(3H,7H)-dione;Xanthione;usafcb-17
- CBNumber
- CB0197999
- Molecular Formula
- C5H4N4O2
- Formula Weight
- 152.11
- MOL File
- 69-89-6.mol
Xanthine Property
- Melting point:
- 300 °C
- Boiling point:
- 274.55°C (rough estimate)
- Density
- 1.5452 (rough estimate)
- vapor density
- 5.3 (vs air)
- refractive index
- 1.8500 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- NH4OH: freely soluble
- pka
- pKa 9.95 (Uncertain)
- form
- Powder
- color
- White to slightly yellow
- Odor
- Odorless
- Water Solubility
- Soluble in water(0.067g/L).
- Merck
- 14,10059
- BRN
- 8733
- InChIKey
- LRFVTYWOQMYALW-UHFFFAOYSA-N
- LogP
- -0.730
- CAS DataBase Reference
- 69-89-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Xanthine(69-89-6)
- EPA Substance Registry System
- Xanthine (69-89-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-43-36/37/38
- Safety Statements
- 36/37-37/39-26
- WGK Germany
- 3
- RTECS
- ZD7700000
- TSCA
- Yes
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- X0626
- Product name
- Xanthine
- Purity
- ≥99.5% (HPLC), purified by recrystallization
- Packaging
- 5g
- Price
- $94.6
- Updated
- 2024/03/01
- Product number
- X0004
- Product name
- Xanthine
- Purity
- >98.0%(HPLC)
- Packaging
- 25g
- Price
- $65
- Updated
- 2024/03/01
- Product number
- A11077
- Product name
- Xanthine, 99%
- Packaging
- 25g
- Price
- $84
- Updated
- 2024/03/01
- Product number
- A11077
- Product name
- Xanthine, 99%
- Packaging
- 100g
- Price
- $207.65
- Updated
- 2024/03/01
- Product number
- X7375
- Product name
- Xanthine
- Purity
- ≥99%
- Packaging
- 10g
- Price
- $73.4
- Updated
- 2024/03/01
Xanthine Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystalline powder
Uses
2,6-Dihydroxypurine was fund in animal organs, yeast, patatoes, coffee beans, tea. 2,6-Dihydroxypurine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives have adenoside receptor antagonist properties.
Uses
Xanthine and xanthine oxidase system can be used to produce superoxide radicals.
Definition
A poisonous colorless crystalline organic compound that occurs in blood, coffee beans, potatoes, and urine. It is used as a chemical intermediate.
Definition
Xanthine: a purine base, C5H4N4O2,found in many organisms.
Origin
Xanthines (1H-purine-2,6(3H,7H)-diones) are purine based natural heterocyclic alkaloids. They were first discovered in 1817 by German chemist Emil Fisher and later the name ‘xanthine’ was coined in 1899[1].
Biological Functions
In fact, xanthine and its derivatives act as intermediate molecules in generation of GMP, GDP and GTP via the salvage pathway inside the cells. In addition, xanthine plays imperative role in catabolism of nucleotides and nucleic acids as xanthine acts as precursor of uric acid. Therefore, xanthine contains similar skeleton as that of purines which forms the building blocks of unit of life i.e. ribonucleotides (RNA) and deoxyribonucleotides (DNA). The structural resemblance with two of the important purine derivatives Adenine and Guanine; makes xanthine a good therapeutic molecule[1].
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 22, p. 1200, 1974 DOI: 10.1248/cpb.22.1200
General Description
Xanthine is a purine that can be produced in the purine metabolic pathway via different precursors:
- Guanine deamination by guanine deaminase
- Hypoxanthine conversion by xanthine oxidoreductase
Biochem/physiol Actions
A high level of xanthine is implicated in metabolic disorders like Lesch-Nyhan syndrome. A xanthine-based biosensor may be useful for detecting xanthine in food and clinical samples. Blood and urine samples of patients with renal failure, gout and xanthinuria show high levels of xanthine.
Purification Methods
The monohydrate separates in a microcrystalline form on slow acidification with acetic acid of a solution of xanthine in dilute NaOH. It is also precipitated by addition of conc NH3 to its solution in hot 2N HCl (charcoal). After washing with H2O and EtOH, it is dehydrated by heating above 125o. Its solubility in H2O is 1 in 14,000parts at 16o and 1 in 1,500parts of boiling H2O, and separates as plates . It has no m, but the perchlorate has m 262-264o [Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp252-253 1971, ISBN 0-471-38205-1]. [Beilstein 26 H 447, 26 I 131, 26 II 260, 26 III/IV 2327.]
References
[1] Ahlawat, Jyoti Minakshi Sharma and Chandra S. Pundir. “Advances in xanthine biosensors and sensors: A review.” Enzyme and Microbial Technology 69 1 (2023).
Xanthine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Xanthine manufacturers
- Product
- 2,6-Dihydroxypurine 69-89-6
- Price
- US $9.90/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-03-18
- Product
- 2,6-Dihydroxypurine 69-89-6
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 1000
- Release date
- 2024-03-21
- Product
- 2,6-Dihydroxypurine 69-89-6
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-11-02