ChemicalBook > CAS DataBase List > Oxipurinol

Oxipurinol

Product Name
Oxipurinol
CAS No.
2465-59-0
Chemical Name
Oxipurinol
Synonyms
Oxyprim;BW-55-5;NSC-76239;OXIPURINOL;OXYPURINOL;1,7-Dihydro-;Alloxanthine;Oxoallopurinol;Allopurinol Impurity5;Allopurinol Impurity 6
CBNumber
CB4709190
Molecular Formula
C5H4N4O2
Formula Weight
152.11
MOL File
2465-59-0.mol
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Oxipurinol Property

Melting point:
300 °C
Boiling point:
274.55°C (rough estimate)
Density 
1.637
refractive index 
1.8500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO.
pka
pKa 7.7 (Uncertain)
form 
Powder
color 
Light yellow
BRN 
139956
Stability:
Hygroscoipic
CAS DataBase Reference
2465-59-0(CAS DataBase Reference)
EPA Substance Registry System
Oxypurinol (2465-59-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O6881
Product name
Oxypurinol
Purity
≥98% (HPLC)
Packaging
100mg
Price
$227
Updated
2024/03/01
Sigma-Aldrich
Product number
42688
Product name
Oxypurinol
Purity
analytical standard
Packaging
10mg
Price
$99
Updated
2022/05/15
Alfa Aesar
Product number
L07160
Product name
4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%
Packaging
1g
Price
$72.65
Updated
2024/03/01
Alfa Aesar
Product number
L07160
Product name
4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%
Packaging
5g
Price
$238.65
Updated
2024/03/01
Cayman Chemical
Product number
18716
Product name
Oxipurinol
Purity
≥95%
Packaging
1g
Price
$115
Updated
2024/03/01
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Oxipurinol Chemical Properties,Usage,Production

Chemical Properties

Off White Solid

Uses

4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine is an inhibitor to study the specificity and kinetics of xanthine oxidase. It is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.

Uses

Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.

Uses

A metabolite of Allopurinol.

Definition

ChEBI: A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.

Biological Activity

oxipurinol is a xanthine oxidoreductase inhibitor.xanthine oxidoreductase (xo), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. xo is generally recognized as a critical enzyme in purine catabolism.

Biochem/physiol Actions

An allopurinol metabolite.

in vitro

allopurinol could be rapidly oxidized by xo to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit xo. oxypurinol was identified as a noncompetitive inhibitor of xo; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable xo activities [1].

in vivo

animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1].

References

[1] p. pacher, a. nivorozhkin and c. szabó. therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. pharmacological reviews 58(1), 87-114 (2006).
[2] day ro, graham gg, hicks m, mclachlan aj, stocker sl, williams km. clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. clin pharmacokinet. 2007;46(8):623-44.

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Oxipurinol Suppliers

Shanghai He-H Chemical Technology Co., Ltd
Tel
18621911604
Email
987025641@qq.com
Country
China
ProdList
638
Advantage
58
Shanghai Yichang Chemical Co., Ltd.
Tel
13472573725
Email
sales@yichangchemical.com
Country
China
ProdList
348
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai AmasPharm Co., Ltd.
Tel
021-54540637 18621091017
Fax
021-34978309
Email
sales@amaspharm.com
Country
China
ProdList
723
Advantage
62
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
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View Lastest Price from Oxipurinol manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Oxipurinol 2465-59-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10

2465-59-0, OxipurinolRelated Search:


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  • Heterocycles
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