8-Bromoguanosine

Product Name: 8-Bromoguanosine
CAS No.: 4016-63-1
Chemical Name: 8-Bromoguanosine
Synonyms: γ-GT;NAB-1;8-Br-G;8-Br-rG;8-Br-Gr;NSC 79211;NSC 174257;8-Br-Guanosine;8-BROMOGUANOSINE;8-Bromo-D-guanosine
CBNumber: CB8101198
Molecular Formula: C10H12BrN5O5
Formula Weight: 362.14
MOL File: 4016-63-1.mol

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8-Bromoguanosine Property

Melting point:: 222°C
Boiling point:: 774.0±70.0 °C(Predicted)
Density: 2.62±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO, Methanol (Sparingly), Hot Water
pka: 13.00±0.70(Predicted)
form: Powder
color: Off-white
BRN: 578725
CAS DataBase Reference: 4016-63-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P234Keep only in original container.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P390Absorb spillage to prevent material damage.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4002
Product name: 8-Bromoguanosine Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $42
Updated: 2022/04/27

TCI Chemical

Product number: B4002
Product name: 8-Bromoguanosine Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $123
Updated: 2021/12/16

Cayman Chemical

Product number: 18152
Product name: 8-Bromoguanosine
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18152
Product name: 8-Bromoguanosine
Purity: ≥98%
Packaging: 5g
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 18152
Product name: 8-Bromoguanosine
Purity: ≥98%
Packaging: 10g
Price: $93
Updated: 2024/03/01

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8-Bromoguanosine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

8-Bromoguanosine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase.

Definition

ChEBI: 8-Bromoguanosine is a purine nucleoside.

Synthesis

118-00-3

4016-63-1

Bromine (0.8 mL, 14.6 mmol) was added dropwise to a suspension of guanosine (4.0 g, 14.4 mmol) in water (100 mL), and the rate of addition was controlled so that the reaction mixture returned to colorless after each addition. The addition of bromine was terminated when the reaction mixture took on a yellowish color due to residual bromine. The colorless solid product was collected by rapid filtration and washed sequentially with 60 mL of cold water and 30 mL of cold acetone. The crude product was recrystallized by dissolving in 150 mL of hot water and subsequently dried under vacuum at 60 °C for 6 hours. Finally, 4.4 g (11.8 mmol, 85% yield) of the target compound 13 was obtained as colorless needle-like crystals with a melting point of 198-200 °C. The NMR data were as follows: 1H NMR (400 MHz, DMSO-d6) δ: 10.82 (1H, s), 6.50 (2H, s), 5.69 (1H, d, J = 6.4 Hz), 5.45 (1H, d, J = 6.0 Hz), 5.09 (1H, d, J = 5.2 Hz), 5.02 (1H, dd, J = 6.0, 11.6 Hz), 4.02 (1H, dd, J = 6.0, 11.6 Hz). 11.6 Hz), 4.92 (1H, t, J = 6.0 Hz), 4.14 (1H, m), 3.86 (1H, m), 3.66 (1H, m), 3.52 (1H, m); 13C NMR (100 MHz, DMSO-d6) δ: 155.5, 153.4, 152.0, 121.2, 117.5, 89.7, 85.8, 70.5, 70.3, 62.0.

References

[1] Photochemistry and Photobiology, 2018, vol. 94, # 4, p. 677 - 684
[2] Nucleosides, Nucleotides and Nucleic Acids, 2012, vol. 31, # 10, p. 707 - 719
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 5, p. 382 - 385
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 2, p. 379 - 383
[5] Tetrahedron Letters, 2016, vol. 57, # 27-28, p. 2949 - 2953

8-Bromoguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Bromoguanosine Suppliers

Americas 1 Canada 2 China 163 Europe 1 Germany 5 India 6 Russia 1 Switzerland 1 United Kingdom 13 United States 34 Global 227

J & K SCIENTIFIC LTD.

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View Lastest Price from 8-Bromoguanosine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 8-Bromoguanosine 4016-63-1
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 97%
Supply Ability: 2000
Release date: 2025-06-03

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 8-Bromoguanosine 4016-63-1
Price: US $0.00-0.00/g
Min. Order: 25g
Purity: 98%min
Supply Ability: 100kgs
Release date: 2021-09-07

Henan Aochuang Chemical Co.,Ltd.

Product: 8-Bromoguanosine 4016-63-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

4016-63-1, 8-BromoguanosineRelated Search:

NUCLEOSIDE PHOSPHORYLASE BACTERIAL 6-Thioguanine Adenosine PUROMYCIN AMINONUCLEOSIDE Guanosine 5'-monophosphate disodium salt Guanine 6-Chloropurine ribonucleoside Acyclovir 2-Aminopurine Guanosine 5'-Guanylic acid 2-Amino-6-chloropurine Riboside 6-O-Methyl-guanine 2-BROMO-1-ETHOXYMETHYLIMIDAZOLE Bromine 2-Bromo-1H-imidazole 2-Bromo-1-methyl-1H-imidazole Desciclovir

8-Bromo-D-guanosine

8-BROMOGUANOSINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM

2-AMINO-8-BROMO-6-HYDROXYPURINE RIBOSIDE

8-BROMOGUANOSINE

8-Bromoguanosine ,98%

8-Br-G

2-aMino-8-broMo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one

NAB-1

2-amino-8-bromo-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one

B**8-BROMOGUANOSINE

NSC 174257

NSC 79211

2-aMino-8-broMo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

8-Bromoguanine riboside, 8-Bromo-9-(beta-D-ribofuranosyl)guanine

8-Br-rG

8-Br-Guanosine

8-Br-Gr

8-Bromoguanosine Hydrate&gt

Guanosine, 8-bromo-

8-Bromoguanosine USP/EP/BP

γ-GT

4016-63-1

C10H12BrN5O5xH2O

C10H12BrN5O5

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

BioChemical

Biochemicals and Reagents

Pyridines, Pyrimidines, Purines and Pteredines

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides