8-Bromoguanosine
- Product Name
- 8-Bromoguanosine
- CAS No.
- 4016-63-1
- Chemical Name
- 8-Bromoguanosine
- Synonyms
- γ-GT;NAB-1;8-Br-G;8-Br-rG;8-Br-Gr;NSC 79211;NSC 174257;8-Br-Guanosine;8-BROMOGUANOSINE;8-Bromo-D-guanosine
- CBNumber
- CB8101198
- Molecular Formula
- C10H12BrN5O5
- Formula Weight
- 362.14
- MOL File
- 4016-63-1.mol
8-Bromoguanosine Property
- Melting point:
- 222°C
- Boiling point:
- 774.0±70.0 °C(Predicted)
- Density
- 2.62±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO, Methanol (Sparingly), Hot Water
- pka
- 13.00±0.70(Predicted)
- form
- Powder
- color
- Off-white
- BRN
- 578725
- CAS DataBase Reference
- 4016-63-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- HS Code
- 29389090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P234Keep only in original container.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P390Absorb spillage to prevent material damage.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B4002
- Product name
- 8-Bromoguanosine Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $42
- Updated
- 2022/04/27
- Product number
- B4002
- Product name
- 8-Bromoguanosine Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $123
- Updated
- 2021/12/16
- Product number
- 18152
- Product name
- 8-Bromoguanosine
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18152
- Product name
- 8-Bromoguanosine
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 18152
- Product name
- 8-Bromoguanosine
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $93
- Updated
- 2024/03/01
8-Bromoguanosine Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
8-Bromoguanosine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase.
Definition
ChEBI: 8-Bromoguanosine is a purine nucleoside.
Synthesis
118-00-3
4016-63-1
Bromine (0.8 mL, 14.6 mmol) was added dropwise to a suspension of guanosine (4.0 g, 14.4 mmol) in water (100 mL), and the rate of addition was controlled so that the reaction mixture returned to colorless after each addition. The addition of bromine was terminated when the reaction mixture took on a yellowish color due to residual bromine. The colorless solid product was collected by rapid filtration and washed sequentially with 60 mL of cold water and 30 mL of cold acetone. The crude product was recrystallized by dissolving in 150 mL of hot water and subsequently dried under vacuum at 60 °C for 6 hours. Finally, 4.4 g (11.8 mmol, 85% yield) of the target compound 13 was obtained as colorless needle-like crystals with a melting point of 198-200 °C. The NMR data were as follows: 1H NMR (400 MHz, DMSO-d6) δ: 10.82 (1H, s), 6.50 (2H, s), 5.69 (1H, d, J = 6.4 Hz), 5.45 (1H, d, J = 6.0 Hz), 5.09 (1H, d, J = 5.2 Hz), 5.02 (1H, dd, J = 6.0, 11.6 Hz), 4.02 (1H, dd, J = 6.0, 11.6 Hz). 11.6 Hz), 4.92 (1H, t, J = 6.0 Hz), 4.14 (1H, m), 3.86 (1H, m), 3.66 (1H, m), 3.52 (1H, m); 13C NMR (100 MHz, DMSO-d6) δ: 155.5, 153.4, 152.0, 121.2, 117.5, 89.7, 85.8, 70.5, 70.3, 62.0.
References
[1] Photochemistry and Photobiology, 2018, vol. 94, # 4, p. 677 - 684
[2] Nucleosides, Nucleotides and Nucleic Acids, 2012, vol. 31, # 10, p. 707 - 719
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 5, p. 382 - 385
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 2, p. 379 - 383
[5] Tetrahedron Letters, 2016, vol. 57, # 27-28, p. 2949 - 2953
8-Bromoguanosine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 8-Bromoguanosine manufacturers
- Product
- 8-Bromoguanosine 4016-63-1
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 97%
- Supply Ability
- 2000
- Release date
- 2025-06-03
- Product
- 8-Bromoguanosine 4016-63-1
- Price
- US $0.00-0.00/g
- Min. Order
- 25g
- Purity
- 98%min
- Supply Ability
- 100kgs
- Release date
- 2021-09-07
- Product
- 8-Bromoguanosine 4016-63-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26