ChemicalBook > CAS DataBase List > Xanthine

Xanthine

Product Name
Xanthine
CAS No.
69-89-6
Chemical Name
Xanthine
Synonyms
XANTHINE;Xan;Xanthin;ISOXANTHINE;3,7-Dihydro-1H-purine-2,6-dione;7H-xanthine;9H-PURINE-2,6-DIOL;1H-Purine-2,6(3H,7H)-dione;Xanthione;usafcb-17
CBNumber
CB0197999
Molecular Formula
C5H4N4O2
Formula Weight
152.11
MOL File
69-89-6.mol
More
Less

Xanthine Property

Melting point:
300 °C
Boiling point:
274.55°C (rough estimate)
Density 
1.5452 (rough estimate)
vapor density 
5.3 (vs air)
refractive index 
1.8500 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
NH4OH: freely soluble
pka
pKa 9.95 (Uncertain)
form 
Powder
color 
White to slightly yellow
Odor
Odorless
Water Solubility 
Soluble in water(0.067g/L).
Merck 
14,10059
BRN 
8733
InChIKey
LRFVTYWOQMYALW-UHFFFAOYSA-N
LogP
-0.730
CAS DataBase Reference
69-89-6(CAS DataBase Reference)
NIST Chemistry Reference
Xanthine(69-89-6)
EPA Substance Registry System
Xanthine (69-89-6)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36-43-36/37/38
Safety Statements 
36/37-37/39-26
WGK Germany 
3
RTECS 
ZD7700000
TSCA 
Yes
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
X0626
Product name
Xanthine
Purity
≥99.5% (HPLC), purified by recrystallization
Packaging
5g
Price
$94.6
Updated
2024/03/01
TCI Chemical
Product number
X0004
Product name
Xanthine
Purity
>98.0%(HPLC)
Packaging
25g
Price
$65
Updated
2024/03/01
Alfa Aesar
Product number
A11077
Product name
Xanthine, 99%
Packaging
25g
Price
$84
Updated
2024/03/01
Alfa Aesar
Product number
A11077
Product name
Xanthine, 99%
Packaging
100g
Price
$207.65
Updated
2024/03/01
Sigma-Aldrich
Product number
X7375
Product name
Xanthine
Purity
≥99%
Packaging
10g
Price
$73.4
Updated
2024/03/01
More
Less

Xanthine Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

2,6-Dihydroxypurine was fund in animal organs, yeast, patatoes, coffee beans, tea. 2,6-Dihydroxypurine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives have adenoside receptor antagonist properties.

Uses

Xanthine and xanthine oxidase system can be used to produce superoxide radicals.

Definition

A poisonous colorless crystalline organic compound that occurs in blood, coffee beans, potatoes, and urine. It is used as a chemical intermediate.

Definition

Xanthine: a purine base, C5H4N4O2,found in many organisms.

Origin

Xanthines (1H-purine-2,6(3H,7H)-diones) are purine based natural heterocyclic alkaloids. They were first discovered in 1817 by German chemist Emil Fisher and later the name ‘xanthine’ was coined in 1899[1].

Biological Functions

In fact, xanthine and its derivatives act as intermediate molecules in generation of GMP, GDP and GTP via the salvage pathway inside the cells. In addition, xanthine plays imperative role in catabolism of nucleotides and nucleic acids as xanthine acts as precursor of uric acid. Therefore, xanthine contains similar skeleton as that of purines which forms the building blocks of unit of life i.e. ribonucleotides (RNA) and deoxyribonucleotides (DNA). The structural resemblance with two of the important purine derivatives Adenine and Guanine; makes xanthine a good therapeutic molecule[1].

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 22, p. 1200, 1974 DOI: 10.1248/cpb.22.1200

General Description

Xanthine is a purine that can be produced in the purine metabolic pathway via different precursors:

  • Guanine deamination by guanine deaminase
  • Hypoxanthine conversion by xanthine oxidoreductase

Biochem/physiol Actions

A high level of xanthine is implicated in metabolic disorders like Lesch-Nyhan syndrome. A xanthine-based biosensor may be useful for detecting xanthine in food and clinical samples. Blood and urine samples of patients with renal failure, gout and xanthinuria show high levels of xanthine.

Purification Methods

The monohydrate separates in a microcrystalline form on slow acidification with acetic acid of a solution of xanthine in dilute NaOH. It is also precipitated by addition of conc NH3 to its solution in hot 2N HCl (charcoal). After washing with H2O and EtOH, it is dehydrated by heating above 125o. Its solubility in H2O is 1 in 14,000parts at 16o and 1 in 1,500parts of boiling H2O, and separates as plates . It has no m, but the perchlorate has m 262-264o [Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp252-253 1971, ISBN 0-471-38205-1]. [Beilstein 26 H 447, 26 I 131, 26 II 260, 26 III/IV 2327.]

References

[1] Ahlawat, Jyoti Minakshi Sharma and Chandra S. Pundir. “Advances in xanthine biosensors and sensors: A review.” Enzyme and Microbial Technology 69 1 (2023).

Xanthine Preparation Products And Raw materials

Raw materials

Semicarbazide Imidazole Diethyl carbonate

Preparation Products

Caffeine 6-Mercaptopurine 2-Chloroadenine Theobromine
More
Less

Xanthine Suppliers

Belgium 3 Canada 3 CHINA 414 Europe 4 France 1 Germany 13 India 26 Japan 8 Poland 1 Russia 1 Slovakia 1 South Korea 1 Switzerland 6 The Netherlands 1 United Kingdom 17 United States 67 Global 567
Zhenjiang Hongyu Biotechnology Co., Ltd
Tel
15159105787 15189105787
Email
19708301@qq.com
Country
China
ProdList
34
Advantage
58
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
15928766785 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
1995
Advantage
55
Hu' nan Yunbang Pharmaceutical Co., Ltd.
Tel
0731-85561020 15386497078
Email
yunbang@yunbangapi.com
Country
China
ProdList
4200
Advantage
58
Shandong Shenganbei New Energy Co. , Ltd. . Nanjing branch
Tel
18914494296
Email
sab202211@163.com
Country
China
ProdList
1603
Advantage
58
Hangzhou Qianhui Biotechnology Co., LTD
Tel
0571-16680502907 16680502907
Email
640280132@qq.com
Country
China
ProdList
794
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
ProdList
776
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3296
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1937
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2893
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8888
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Runpharm Technology Limited
Tel
18171398856 2968382473
Fax
0086-21-50758330
Email
service@runpharm.com
Country
China
ProdList
718
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
973
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
More
Less

View Lastest Price from Xanthine manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
2,6-Dihydroxypurine 69-89-6
Price
US $9.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-03-18
hebei hongtan Biotechnology Co., Ltd
Product
2,6-Dihydroxypurine 69-89-6
Price
US $80.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
1000
Release date
2024-03-21
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
2,6-Dihydroxypurine 69-89-6
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-02

69-89-6, XanthineRelated Search:

XANTHOSINE Diprophylline 8-Bromotheophylline 3-ISOBUTYL-1-METHYLXANTHINE ISOCAFFEINE Aminophylline 7-METHYLXANTHINE CAFFEINE PROXYPHYLLINE XANTHOSINE 5'-MONOPHOSPHATE DISODIUM SALT 7-(2-CHLOROETHYL)THEOPHYLLINE Theophylline-7-acetic acid 3-Methylxanthine 1,7-DIMETHYLXANTHINE 8-Aza-2,6-dihydroxypurine, Semihydrate, 3H-1,2,3-Triazolo(4,5-d)pyrimidine-5,7-diol 3-METHYL-7-PROPYL-2,6-DIHYDROXYPURINE 2,6-DIHYDROXYPURINE SODIUM SALT Oxipurinol

  • ISOXANTHINE
  • 2,6-DIOXOPURINE
  • 2,6-DIOXYPURINE
  • 2,6-DIHYDROXYPURINE
  • 9H-PURINE-2,6-DIOL
  • PURINE-2,6(1H,3H)-DIONE
  • TIMTEC-BB SBB004054
  • UREOUS ACID
  • XANTHINE
  • 3,7-Dihydro-1H-purine-2,6-dione
  • 3,7-dihydro-1h-purine-6-dione
  • 1H-Purine-2,6-diol
  • 1H-Purine-2,6-dione, 3,7-dihydro-
  • 2,6(1,3)-Purinedion
  • 2,6-Dioxo-1,2,3,6-tetrahydropurine
  • 2,6-Dixoxpurine
  • purine-2(3H),6(1H)-dione
  • xanthine 99-100%
  • xanthine sigmaultra
  • 2,6-DihydroxyPurine(Xanthine)
  • XanthineForBiochemistry
  • Lutein(MarigoldP.E)5%,20%ByHplc
  • Xanthine, 98+%
  • Xanthine,99%
  • 2,6[1,3]-Purinedione
  • 2,6-dihydroxypurin
  • Xanthione
  • XANTHINE OR 2,6-DIHYDROXYPURINE
  • XANTHINE(RG)
  • Xanthine (2,6-Dihydroxypurine)
  • 2,6-Dihydropurine
  • 2,6(1H,3H)purinedione
  • 6-dione,3,7-dihydro-1H-Purine-2
  • 9h-purine-2,6-(1h,3h)-dione
  • 9H-Purine-2,6(1H,3H)-dione
  • Dioxopurine
  • Pseudoxanthine
  • Purine-2,6-diol
  • USAF CB-17
  • usafcb-17
  • Xan
  • Xanthic oxide
  • xanthicoxide
  • Xanthin
  • XANTHINE extrapure CHR
  • 3,9-Dihydropurine-2,6-dione
  • H,3H,7H-Xanthine
  • 1H-Purine-2,6(3H,7H)-dione
  • 1H-Purine-2,6-dione
  • XANTHINEANALYTICAL GRADE
  • 3,7-Dihydroxy-1H-purine-2,6-dione
  • 2,3,6,7-tetrahydro-1H-purine-2,6-dione
  • Xanthine, 98% 25GR
  • Xanthine, 98% 5GR
  • 1H,3H,7H-Xanthine
  • 1H,3H,9H-Xanthine
  • 7H-xanthine
  • 3,7-dihydropurine-2,6-dione