ChemicalBook > CAS DataBase List > 4-Cbz-Aminopiperidine

4-Cbz-Aminopiperidine

Product Name: 4-Cbz-Aminopiperidine
CAS No.: 182223-54-7
Chemical Name: 4-Cbz-Aminopiperidine
Synonyms: 4-CBZ-AMINOPIPERIDINE;4-(Z-amino)-piperidine;N-CBZ-piperidin-4-aMine;Benzylpiperidin-4-ylcarbamate;Benzyl 4-Piperidinylcarbamate;4-Benzyloxycarbonylamino-piperdine;benzyl N-(piperidin-4-yl)carbaMate;4-BENZYLOXYCARBONYLAMINO-PIPERIDINE;Phenylmethyl N-4-piperidinylcarbamate;benzyl piperidin-4-ylcarbamate hydrochloride
CBNumber: CB7756599
Molecular Formula: C13H18N2O2
Formula Weight: 234.29
MOL File: 182223-54-7.mol

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4-Cbz-Aminopiperidine Property

Boiling point:: 396.3±41.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Dichloromethane
form: Solid
pka: 12.18±0.20(Predicted)
color: White
InChI: InChI=1S/C13H18N2O2/c16-13(15-12-6-8-14-9-7-12)17-10-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2,(H,15,16)
InChIKey: WWGUAFRTAYMNHU-UHFFFAOYSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)NC1CCNCC1

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Safety

Safety Statements: 24/25
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B285871
Product name: 4-Benzyloxycarbonylaminopiperidine
Packaging: 1g
Price: $165
Updated: 2021/12/16

TRC

Product number: B285871
Product name: 4-Benzyloxycarbonylaminopiperidine
Packaging: 2.5g
Price: $330
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK501176
Product name: 4-Cbz-aminopiperidine
Purity: 97%
Packaging: 1g
Price: $385
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC148389
Product name: 4-Cbz-aminopiperidine
Packaging: 5G
Price: $400
Updated: 2021/12/16

Apolloscientific

Product number: OR301035
Product name: 4-Benzyloxycarbonylaminopiperidine
Packaging: 10g
Price: $508
Updated: 2021/12/16

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4-Cbz-Aminopiperidine Chemical Properties,Usage,Production

Uses

4-Benzyloxycarbonylaminopiperidine is an intermediate in synthesizing 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin (E899150), a major metabolite of Irinotecan.

Definition

ChEBI: Benzyl 4-piperidinylcarbamate is a member of piperidines.

Synthesis

220394-97-8

182223-54-7

The general procedure for the synthesis of 4-(N-benzyloxycarbonyl)-aminopiperidine from 1-Boc-4-(Cbz-amino)piperidine was as follows: tert-butyl 4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (13.1 g, 39.2 mmol) obtained in Example 1a was mixed with a 5N aqueous hydrochloric acid (40 ml, 200 mmol) and a methanolic (40 ml) The mixture was stirred at room temperature for 23 hours. After completion of the reaction, 5N aqueous sodium hydroxide solution (40 ml) was slowly added to the reaction mixture under ice bath cooling conditions. Subsequently, water and solvent were removed from the reaction mixture by distillation while azeotropic distillation using ethanol was carried out to remove water completely. Ethanol was added to the distilled residue, filtered to remove insoluble matter, and the filtrate was concentrated to give the final 4-(N-benzyloxycarbonyl)-aminopiperidine (9.10 g, 99.1% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) with the following chemical shifts δppm: 1.31-1.42 (2H, m), 1.92-2.04 (2H, br), 2.70 (2H, d, J = 12Hz), 3.10 (2H, d, J = 12Hz), 3.56-3.68 (1H, br), 4.72- 4.81 (1H, br), 5.09 (2H, s), 7.26-7.40 (5H, m).

References

[1] Patent: US2013/65925, 2013, A1. Location in patent: Paragraph 0197; 0198
[2] Patent: EP2757103, 2014, A1. Location in patent: Paragraph 0149
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1021 - 1046
[4] Patent: WO2011/60321, 2011, A1. Location in patent: Page/Page column 115
[5] Patent: WO2006/99884, 2006, A1. Location in patent: Page/Page column 18

4-Cbz-Aminopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Cbz-Aminopiperidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-CBZ-piperidin-4-aMine 182223-54-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 4-Cbz-Aminopiperidine 182223-54-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

182223-54-7, 4-Cbz-AminopiperidineRelated Search:

Haloperidol Benzyl chloroformate 1-Aminopiperidine Trimethoprim Benzyl carbamate Benzyloxyacetyl chloride Nequinate 1-BOC-4-CBZ-AMINO-PIPERIDINE 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)- Piperidine 3-CBZ-AMINOPIPERIDINE,3-CBZ-AMINOPIPERIDINE HCL,3-N-Cbz-aminopiperidine hydrochloride 1-BOC-4-N-CBZ-AMINOPIPERIDINE-4-CARBOXYLIC ACID 4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE METHYL-(1-METHYL-4-PYRROLIDIN-1-YLMETHYL-PIPERIDIN-4-YL)-CARBAMIC ACID BENZYL ESTER L371,257 4-BENZYLOXYCARBONYLAMINO-4-METHYL-PIPERIDINE 4-Cbz-Aminopiperidine (4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride

Carbamic acid, 4-piperidinyl-, phenylmethyl ester

benzyl piperidin-4-ylcarbamate hydrochloride

N-CBZ-piperidin-4-aMine

benzyl N-(piperidin-4-yl)carbaMate

4-Benzyloxycarbonylamino-piperdine

4-CBZ-AMINOPIPERIDINE

4-BENZYLOXYCARBONYLAMINO-PIPERIDINE

Carbamic acid, 4-piperidinyl-, phenylmethyl ester (9CI)

Benzylpiperidin-4-ylcarbamate

Carbamic acid, N-4-piperidinyl-, phenylmethyl ester

4-(Z-amino)-piperidine

Benzyl 4-Piperidinylcarbamate

Phenylmethyl N-4-piperidinylcarbamate

182223-54-7

pharmacetical

API intermediates

N-CBZ